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Antibacterial and injectable temperature-sensitive chitosan gel dressing and preparation method thereof

A temperature-sensitive chitosan gel and injectable technology, which is applied in the field of medical antibacterial dressings, can solve the problems of poor antibacterial properties of pure chitosan, and achieve the effects of improving water solubility, antibacterial properties, and practicality

Inactive Publication Date: 2019-04-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial performance of pure chitosan is not good, and various chitosan derivatives prepared by modifying chitosan all have certain antibacterial performance. Among them, the antibacterial performance of quaternized chitosan is obviously better than that of Pure chitosan and other chitosan derivatives

Method used

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  • Antibacterial and injectable temperature-sensitive chitosan gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Prepare a certain concentration of the following solution for use: chitosan acetic acid aqueous solution mass fraction 1%;

[0028] 2) Add 5 mL of glycidyltrimethylammonium chloride to 5 mL of chitosan acetic acid aqueous solution, and heat to react for 3 hours;

[0029] 3) 20 parts of quaternized chitosan, 2 parts of hydrochloric acid, 5 parts of initiator, 10 parts of N-isopropylacrylamide monomer, 63 parts of deionized water are mixed by mass, and after stirring and dissolving, the ℃, emulsion polymerization reaction for 2 hours;

[0030] 4) An aqueous solution system is finally prepared, which is sprayed on the body surface to form a gel dressing.

Embodiment 2

[0032] 1) Prepare a certain concentration of the following solution for use: chitosan acetic acid aqueous solution mass fraction 5%;

[0033] 2) Add 0.5mL glycidyltrimethylammonium chloride to 10mL chitosan acetic acid aqueous solution, and heat to react for 8 hours;

[0034] 3) Mix 10 parts of quaternized chitosan, 2 parts of acetic acid, 1 part of initiator, 10 parts of N-isopropylacrylamide monomer, and 77 parts of deionized water by mass, stir and dissolve, and heat at 90 °C , emulsion polymerization for 5 hours;

[0035] 4) An aqueous solution system is finally prepared, which is sprayed on the body surface to form a gel dressing.

Embodiment 3

[0037] 1) Prepare a certain concentration of the following solution for use: chitosan acetic acid aqueous solution mass fraction 3%;

[0038] 2) Add 1 mL glycidyltrimethylammonium chloride to 8 mL chitosan acetic acid aqueous solution, and heat for 10 hours;

[0039] 3) Mix 5 parts of quaternized chitosan, 1 part of hydrochloric acid, 3 parts of initiator, 5 parts of N-isopropylacrylamide monomer, and 86 parts of deionized water by mass, stir and dissolve, and heat at 40 °C , emulsion polymerization for 3 hours;

[0040] 4) An aqueous solution system is finally prepared, which is sprayed on the body surface to form a gel dressing.

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Abstract

The invention discloses antibacterial and injectable temperature-sensitive chitosan gel dressing and a preparation method thereof. The dressing has the antibacterial function and the temperature-sensitive performance, and it can be achieved that the dressing is instantly congealed while sprayed. The preparation method of the antibacterial and injectable temperature-sensitive chitosan gel dressingcomprises the following steps that quaternized chitosan is prepared, the main chain of the chitosan is grafted with poly(N-isopropyl acrylamide)(PNIPAM) through an emulsion polymerization reaction, and accordingly, the antibacterial and injectable temperature-sensitive chitosan gel dressing is prepared. The dressing is high in water solubility at the room temperature, and the antibacterial temperature-sensitive chitosan gel dressing can be used after spray coating.

Description

technical field [0001] The invention belongs to the field of medical antibacterial dressings, in particular to an antibacterial and injectable temperature-sensitive chitosan gel dressing and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin can effectively prevent the loss of water, electrolytes and plasma proteins, resist the invasion of bacteria, prevent the entry of poisons, and resist mechanical damage. However, in daily life, the skin will be damaged due to trauma, burns, scalds and ulcers, which will further lead to bacterial infection and endanger human health. Therefore, there is an urgent need to develop a suitable wound dressing. In addition to being a temporary substitute for the skin, this material also needs to have certain antibacterial and anti-infection capabilities to promote wound healing. [0003] Chitosan is the second largest biomacromolecule in nature after cellulose. Among them, chitosan gel ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/208A61L2300/404A61L2400/06C08L5/08C08L33/26
Inventor 王征科鲍晓炯董晓飞乔丰慧姜质琦金晓强傅倍佳胡巧玲
Owner ZHEJIANG UNIV
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