Method for simultaneously measuring various endocrine disruptors in environment water sample

Abstract

The invention discloses a method for simultaneously measuring various endocrine disruptors in an environment water sample, and belongs to the field of environment detection. The method includes the steps of firstly, taking a water sample, taking supernate after conducting natural depositing or centrifuging, enriching the supernate through an activated solid-phase extraction small column by means of a solid-phase extraction device, and conducting centrifuging or vacuum drying on the extraction column after enriching; secondly, eluting the extraction column through an organic solvent, and conducting volume fixing through methyl alcohol after eluant is concentrated to prepare to-be-measured liquid; thirdly, establishing a quantifying method of target pollutants; fourthly, measuring the concentration of the endocrine disruptors in the water sample through the efficient liquid-phase chromatography-triple quadrupole mass spectrometry. The method is small in reagent consumption, low in cost and few in step, but can simultaneously quantitatively analyze the endocrine disruptors in the water body, several types to more than one dozen of types of traditional concerned endocrine disruptors are expanded into 103 types of endocrine disruptors, the analysis flux is greatly improved, the application range is expanded, and the potential high-risk endocrine disruptors in the environment water sample can be better recognized.

Description

technical field [0001] The invention belongs to the field of environmental detection, and more specifically relates to a method for simultaneously measuring multiple endocrine disruptors in environmental water samples. Background technique [0002] Endocrine Disrupting Chemicals (EDCs), also known as Environmental Hormone, are hormones or compounds that can affect the endocrine disrupting system of humans or wild animals. They enter organisms through ingestion, accumulation and other ways, but they do not directly bring abnormal effects on organisms as toxic substances, but act similar to hormones on organisms. Even at extremely low concentrations, they can make organisms The endocrine imbalance of human body causes various abnormal effects. Such substances can interfere with the endocrine regulation function of organisms at low concentrations, and have adverse effects on reproductive and developmental functions, so they have attracted much attention. Studies have shown th...

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Problems solved by technology

[0008] Aiming at the limitations of the existing quantitative detection methods for endocrine disruptors, such as low throughput and simultaneous detection of a single category of endocrine disruptors, the present invention provides a method for simultaneous determination of multiple endocrine disruptors in environmental water samples, aimed at pesticides, Herbicides, organophosphorus pesticides, organochlorine pesticides, phthalates, steroid hormones, flame retardants, pharmaceuticals and personal care products, industrial intermediates, etc., including phenols, ketones, carboxylic acids, esters , nitriles, amines and more than a hundred kinds of endocrine disruptors, and screened out a single adsorbent solid-phase extraction method with high commercialization, high quality control and low cost, using high performance liquid chromatography-triple quadrupole mass spectrometry High-throughput quantitative determination of endocrine disruptors in environmental water samples

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