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Feilike mixture extract and use thereof and quality control method

A technology for mixture and extract, applied in the field of quality control of Feilike mixture extract, can solve the problems of low transfer rate of baicalin, inconsistent preparation methods, no quality identification standards, etc., and achieves improvement of baicalin content and extraction method. Simple, control the effect of product quality

Pending Publication Date: 2019-04-30
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of Feilike mixture extract is not uniform at present, and the transfer rate of baicalin is low. 21 h 18 o 11 ), less than 3.5mg, and there is no quality identification standard

Method used

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  • Feilike mixture extract and use thereof and quality control method
  • Feilike mixture extract and use thereof and quality control method
  • Feilike mixture extract and use thereof and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, the preparation method of Feilike mixture extract

[0026] The preparation method of Feilike mixture extract comprises the steps of: taking 29g of Scutellaria baicalensis, 28g of Radix Peucedanum, 28g of Baibu, 28g of Gentiana safflower, 26g of Wutong root, 25g of Hedyotis diffusa, 23g of red pipe medicine according to the prescription, adding water Decoct twice, add boiling water equivalent to 7 times the weight of the medicinal material for 2 hours for the first time, add yu boiling water equivalent to 4 times the weight of the medicinal material for 1.5 hours, combine the decoction liquid, filter, and concentrate the filtrate to Clear paste with a relative density of 1.03 to 1.05 (80°C) is available. The clear paste obtained was brown. Every 1g of Scutellaria baicalensis contains baicalin (C 21 h 18 o 11 ), higher than 3.5mg. Adding boiling water directly in the preparation process helps to improve the conversion rate of baicalin.

[0027] Control...

Embodiment 2

[0028] Embodiment 2, Feilike mixture extract quality control method

[0029] (1) Identification of Radix Peucedanum: Take 3 parts of Feilike mixture extract prepared in Example 1, add water and dilute to 30ml, extract 2 times with ether, 25ml each time, combine the ether solution, evaporate to dryness, add ethyl acetate to the residue 1ml to dissolve, as the test solution.

[0030] Separately take 1 g of Peucedanum as reference medicinal material (batch number: 120951-200704, source: China Institute for the Control of Pharmaceutical and Biological Products), add 20 ml of ether, heat and reflux for 30 minutes, filter, evaporate the filtrate to dryness, add 1 ml of ethyl acetate to dissolve the residue, and use it as a control Medicinal solution.

[0031] And the extract of Herba Peucedanum was treated as the negative control solution according to the test sample.

[0032]According to the test of thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2010 Edition)...

Embodiment 3

[0047] Embodiment 3, detection method reliability

[0048] (1) Specificity

[0049] Preparation of negative solution: Get 0.5 g of the extractum lacking Scutellaria baicalensis medicinal material and put it in a 25ml volumetric flask, add an appropriate amount of 75% ethanol, and process according to the test solution to obtain a negative solution.

[0050] Determination method: according to the above-mentioned chromatographic conditions, respectively accurately absorb 10 μ l of the reference substance solution, the test solution, and the negative solution, and inject them into the liquid chromatograph. Requirements, the number of theoretical plates is greater than 2000 in terms of baicalin, the negative sample solution has no interference, and the specificity is strong.

[0051] (2) Linear relationship

[0052] Use the baicalin reference substance stock solution (0.3324mg / ml) to accurately draw (1ml, 2.5ml, 5ml, 8ml, 20ml), put them in 25ml volumetric flasks, add methanol t...

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Abstract

The invention relates to a Feilike mixture extract and use thereof and a quality control method. A preparation method of the Feilike mixture extract comprises the following steps: taking Scutellaria baicalensis, Common hogfenneI root, radix stemonae, gentiana rhodantha, firmiana root, hedyotis diffusa, and threevein aster according to a prescription, crushing Scutellaria baicalensis through a 16-mm sieve plate, and then decocting the Scutellaria baicalensis twice with other 6 herbs by adding boiling water, wherein the first decoction time is characterized in that the boiling water of 7 times the weight of the medicinal materials is added and the materials are decocted for 2 hours, the second decoction time is characterized in that the boiling water of 4 times the weight of the medicinal materials is added and the materials are decocted for 1.5 hours, merging decoction liquid, filtering the decoction liquid, and concentrating a filtrate to a clear paste having a relative density of 1.03to 1.05 (80 DEG C) to obtain the product. The method can fully retain the active ingredients; and the invention also discloses a quality control method for the Feilike mixture extract, which can better control the product quality.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to the extract of Feilike mixture, its application and pharmaceutical composition, and a quality control method for the extract of Feilike mixture. Background technique [0002] Respiratory disease is a common disease with a high incidence rate in the elderly and children. After the onset, it manifests as coughing, panting, poor breathing, and excessive phlegm. Some will stay up all night and affect the patient's health. It also endangers the patient's life. Feilike mixture extract is prepared by extracting and concentrating 29g of Scutellaria baicalensis, 28g of Peucedanum, 28g of Baibu, 28g of Gentiana safflower, 26g of Wutong root, 25g of Hedyotis diffusa, and 23g of red pipe medicine. Above-mentioned disease has better curative effect. However, the preparation method of Feilike mixture extract is not uniform at present, and the transfer rate of baicalin is low. 21 h 18 o 11 ), less th...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61P11/00A61P11/14G01N30/90G01N30/02
CPCA61K9/06A61K36/185A61K36/23A61K36/28A61K36/515A61K36/539A61K36/748A61K36/904A61K2236/331A61K2236/39A61K2236/51A61P11/00A61P11/14G01N30/02G01N30/90A61K2300/00
Inventor 孙小鸚廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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