Cholinesterase inhibitor preparation method

A cholinesterase and inhibitor technology, applied in the field of preparation of cholinesterase inhibitors, can solve the problems of high cost, complex process, low efficiency, etc., and achieve the effects of reducing preparation cost, saving resources, and short process steps

Inactive Publication Date: 2019-04-30
张欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1954, U.S. Patent No. 2,864,848 disclosed a mercury salt precipitation method, which was to precipitate by-products in the form of mercury salts, and remove excess mercury ions by hydrogen sulfide and barium carbonate, but it was difficult to fully remove mercury ions, due to the residual Reactive PC, so it is necessary to add calcium salt to precipitate the new GPC to remove mercury ions, and finally use resin to remove

Method used

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Examples

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Embodiment

[0022] A) produce phenolic resin, be that 3% hydrochloric acid solution is soaked to acrylic macroporous cation exchange resin with mass percent concentration earlier, wherein mass percent concentration is the weight of 3% hydrochloric acid solution and acrylic macroporous cation exchange resin Ratio is 5: 1, and the time of soaking is 150min, drains hydrochloric acid solution after soaking finishes and promptly drains acid solution and rinses to pH7 with deionized water, then uses the sodium hydroxide solution that mass percent concentration is 3% (being alkali liquid) soaking, the weight ratio of the sodium hydroxide solution to the acrylic macroporous cation exchange resin is 4:1, the soaking time of the alkali solution is 150min, and the sodium hydroxide solution is exhausted after the alkali solution soaking is finished, that is, the alkali solution is exhausted , and rinsed again to pH10 with deionized water, then soaked in 3% hydrochloric acid solution for 150min with ma...

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PUM

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Abstract

The invention discloses a cholinesterase inhibitor preparation method, and belongs to the technical field of separation and purification of natural medicines. The preparation method comprises: soakinga macroporous cation exchange resin by using an acid solution, completely removing the acid liquid, rinsing with water, soaking with an alkali liquid, rinsing with water, soaking with an acid liquid,rinsing with deionized water, and replacing with lower alcohol; adding glycerol phosphate to the lower alcohol, adding an alkali, carrying out a reaction, carrying out suction filtration, washing with lower alcohol, adjusting the pH value to a weakly alkaline state, carrying out pressure reducing concentrating, cooling, transferring into a separatory funnel, standing, and separating to obtain a lower layer lower alcohol phase; loading glycerol phosphate and a phenol formaldehyde resin onto a column, loading the alcoholysis mixing liquid onto the column, adsorbing, washing the resin with loweralcohol to remove impurities, and eluting the resin with pure water; and decolorizing with a decolorizing agent, and carrying out pressure reducing concentrating to obtain the finished product. According to the present invention, the process steps are short, the requirements of industrial production are met, the resources are saved, the cost is reduced, the total yield of the finished products is65.47-86.08%, the external standard content is over 99%, and the optical purity is 99%.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of natural medicines, and in particular relates to a preparation method of a cholinesterase inhibitor. Background technique [0002] Glycerol phosphatidylcholine (English name: new glycerophosphorylCholine, abbreviated as new GPC) is a naturally occurring water-soluble phospholipid metabolite in the human body, and it is also a precursor for the synthesis of acetylcholine and phosphatidylcholine (PC). Its structure consists of choline , glycerol and phosphatidyl groups. The new GPC is a cholinesterase inhibitor, which can effectively prevent and treat cerebral ischemic stroke. It can not only improve the memory and cognitive ability of patients, treat Alzheimer's disease and cranial nerve injury, but also resist Muscle atrophy, resist hyperlipidemia and arteriosclerosis, protect blood vessels, etc., so it is widely used in medicine and health care products and other industries...

Claims

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Application Information

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IPC IPC(8): C07F9/09
CPCC07F9/091C07B2200/07
Inventor 张欣
Owner 张欣
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