Novel glycerol phosphatidylcholine preparation method

A glycerol phosphatidylcholine, a new type of technology, applied in the directions of organic chemistry methods, chemical instruments and methods, phosphorus organic compounds, etc., can solve the problems of low efficiency, high cost, complicated process and the like, achieve short process steps and reduce preparation costs , the effect of saving resources

Inactive Publication Date: 2019-04-30
张欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In 1954, U.S. Patent No. 2,864,848 disclosed a mercury salt precipitation method, which was to precipitate by-products in the form of mercury salts, and remove excess mercury ions by hydrogen sulfide and barium carbonate, but it was difficult to fully remove mercury ions, due to the residual Reactive PC, so it is necessary to add calcium salt to precipitate the new GPC to remove mercury ions, and finally use resin to remove

Method used

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Examples

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Embodiment

[0022] A) To prepare a phenolic resin, first soak the acrylic macroporous cation exchange resin with a hydrochloric acid solution with a mass percentage concentration of 3%, and the weight of the 3% hydrochloric acid solution with a mass percentage concentration and the acrylic macroporous cation exchange resin The ratio is 5:1, and the immersion time is 150min. After the immersion, the hydrochloric acid solution is exhausted and the acid solution is exhausted and rinsed with deionized water to pH7, and then replaced with a sodium hydroxide solution with a mass percentage concentration of 3% (ie alkali Soaking, the weight ratio of the sodium hydroxide solution to the acrylic macroporous cation exchange resin is 4:1, the lye soaking time is 150min, after the lye soaking is finished, the sodium hydroxide solution is exhausted and the lye is exhausted , And rinse again with deionized water to pH 10, and then soak again with a hydrochloric acid solution with a concentration of 3% by...

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PUM

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Abstract

The invention discloses a novel glycerol phosphatidylcholine preparation method, and belongs to the technical field of separation and purification of natural medicines. The preparation method comprises: soaking a macroporous cation exchange resin by using an acid solution, completely removing the acid liquid, rinsing with water, soaking with an alkali liquid, rinsing with water, soaking with an acid liquid, rinsing with deionized water, and replacing with lower alcohol; adding glycerol phosphate to the lower alcohol, adding an alkali, carrying out a reaction, carrying out suction filtration, washing with lower alcohol, adjusting the pH value to a weakly alkaline state, carrying out pressure reducing concentrating, cooling, transferring into a separatory funnel, standing, and separating toobtain a lower layer lower alcohol phase; loading glycerol phosphate and a phenol formaldehyde resin onto a column, loading the alcoholysis mixing liquid onto the column, adsorbing, washing the resinwith lower alcohol to remove impurities, and eluting the resin with pure water; and decolorizing with a decolorizing agent, and carrying out pressure reducing concentrating to obtain the finished product. According to the present invention, the process steps are short, the requirements of industrial production are met, the resources are saved, the cost is reduced, the total yield of the finished products is 65.47-86.08%, the external standard content is over 99%, and the optical purity is 99%.

Description

Technical field [0001] The invention belongs to the technical field of separation and purification of natural medicines, and specifically relates to a method for preparing a novel glycerol phosphatidylcholine. Background technique [0002] Glycerol phosphatidylcholine (English name: new glycerophosphorylCholine, abbreviated as new GPC) is a naturally occurring water-soluble phospholipid metabolite in the human body. It is also a precursor for the synthesis of acetylcholine and phosphatidylcholine (PC). Its structure is composed of choline. , Glycerol and phosphatidyl group. The new GPC is a cholinesterase inhibitor, which can effectively prevent and treat cerebral ischemic stroke. It can not only improve the patient's memory and cognitive ability, treat Alzheimer's disease and brain nerve injuries, but also resist Muscle atrophy, resistance to hyperlipidemia and arteriosclerosis, protection of blood vessels, etc., so it is widely used in medicine and health care products. [0003...

Claims

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Application Information

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IPC IPC(8): C07F9/09
CPCC07F9/091C07B2200/07
Inventor 张欣
Owner 张欣
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