Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of cinnabar seven in the preparation of antifungal drugs and their synergists

An antifungal drug and fungal technology, which is applied in the field of medicine, can solve the problem of no synergistic antifungal effect of cinnabar seven, and achieve the effect of reducing drug concentration

Active Publication Date: 2021-11-16
SHAANXI UNIV OF SCI & TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But at present, there is no report on the antifungal effect of cinnabar seven and its synergistic effect on antifungal drugs at home and abroad.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cinnabar seven in the preparation of antifungal drugs and their synergists
  • Application of cinnabar seven in the preparation of antifungal drugs and their synergists
  • Application of cinnabar seven in the preparation of antifungal drugs and their synergists

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0019] 1. Material preparation

[0020] 1. Test drug

[0021] Cinnabar VII: purchased from Chengdu Desite Biotechnology Co., Ltd., purity ≥ 99%, batch number DST170411-006.

[0022] Fluconazole (FLC)): sigma company, lot number 036M4709V.

[0023] Dimethyl sulfoxide: Tianjin Tianli Chemical Reagent Co., Ltd.

[0024] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0025] 2. Strains

[0026] Strains used, including:

[0027] 1) Sensitive strains: sensitive Candida albicans SC5314, Candida parapsilosis 22019 and Cryptococcus neoformans 32609;

[0028] 2) Drug-resistant strains: drug-resistant Candida albicans 103, drug-resistant Candida tropicali...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The antifungal application of the cinnabar seven disclosed by the invention belongs to the technical field of medicine. The present invention shows through in vitro experiments that cinnabar seven has a better inhibitory effect on fungi, and can restore the effect of the antifungal drug fluconazole on drug-resistant fungi, so cinnabar seven can be used as an antifungal drug and an antifungal drug booster. potency. The present invention has opened up new purposes for cinnabar seven, and it is used as the synergist of antifungal drug and antifungal drug, not only provides new candidate drug for fungal treatment, and has improved the antifungal action of existing drug, in When the drug resistance of clinical fungi is becoming more and more common and the degree of drug resistance is becoming more and more serious, the effect of antifungal drugs on drug-resistant fungi can be restored, and the dosage of antifungal drugs can be reduced, thereby saving medical expenses for patients and reducing drug toxicity. side effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of cinnabar seven in the preparation of antifungal drugs and their synergists. Background technique [0002] Cinnabar seven (Polygonum cillinerve), also known as cinnabar lotus, red Yaozi, first recorded in "Tu Jing Materia Medica", is the tuber root of Polygonum cillinerve (Nakai) Ohwl Polygonum genus Polygonum cillinerve. Cool and flat, it has the functions of clearing heat and detoxifying, promoting blood circulation and cooling blood, stopping bleeding and stopping diarrhea, removing rheumatism, strengthening waist and knees, etc. It is one of the important "Taibai Qiyao", and has been listed as a rare authentic herbal medicine in Shaanxi by "Shaanxi Health Records". [0003] But at present, there is no report on the antifungal effect of cinnabar seven and its synergistic effect on antifungal drugs at home and abroad. Contents of the invention ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61P31/10A61K125/00A61K31/4196
Inventor 刘伟孙宝政杨曼曼王胜正张子悦
Owner SHAANXI UNIV OF SCI & TECH