Method for chemically extracting purified water-soluble natural organic substances by solid film

A technology of organic substances and solid membranes, applied in the direction of solvent extraction of liquid solutions, etc., can solve the problems of reducing transmembrane pressure difference, extremely high pressure stability control requirements, and polluting industrial wastewater from extracts, so as to achieve separation efficiency and effect The effect of improving and reducing industrial wastewater discharge and solving potential safety hazards

Active Publication Date: 2019-05-10
GANSU UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, in the inventor's follow-up research, it is found that the extraction method still has the following problems: since alkaloids, flavonoids, anthraquinones, organic acids, etc. are water-soluble organic substances, the overall polarity is relatively large, so that the separated substances are separated in the water phase. The partition coefficient with the organic extraction phase is suitable. This extraction method requires the use of more polar organic solvents, such as ethyl acetate, chloroform, n-butanol, ether, etc. These organic solvents have a certain solubility in water, and the solid film During the extraction process, the organic phase will continuously dissolve into the water phase at the membrane interface where the two phases are in contact, resulting in the continuous reduction of the recy

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  • Method for chemically extracting purified water-soluble natural organic substances by solid film

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Example Embodiment

[0044] Example 1

[0045] Take 50kg of Pueraria lobata root, add 12 times the amount of water to reflux, extract 1.5 hours each time, extract 2 times, and combine to obtain 1100kg of extract; the extract is ultrafiltered with a ceramic membrane with a pore size of 10nm, and the ultrafiltration permeate is collected about 1000kg; % Trialkyl phosphine oxide-sulfonated kerosene is the extractant, 0.05% NaOH solution is the stripping reagent, the ultrafiltration permeate is extracted and stripped according to the specific implementation steps of the present invention, the membrane extraction temperature is 20℃, and the stripping temperature is 35 ℃; the flow velocity of ultrafiltration permeate, extractant, and stripping liquid are 1.0m / min, 0.25m / min, 0.65m / min, and the membrane extraction time is 12 hours; collect the stripping liquid about 1000kg; Adjust the pH value of the solution to 4 with HCl, pass it through a polyamide resin column, eluting with 70% ethanol, collect the elua...

Example Embodiment

[0046] Example 2

[0047] Take 50kg of rhubarb, add 20 times the amount of water to reflux, extract 30min each time, extract 2 times, and combine to obtain 900kg of the extract; the water extract is ultrafiltered with a ceramic composite membrane with a pore size of 20nm to obtain the ultrafiltrate; Adjust the pH to 3.0 with 20% hydrochloric acid solution for the permeate, use 5% trialkylphosphine oxide-sulfonated kerosene as the extractant, 0.5% ammonia as the stripping agent, and extract the ultrafiltration permeate according to the specific implementation steps of the present invention Stripping, membrane extraction temperature is 25℃, stripping temperature is 30℃; the flow speeds of ultrafiltrate, extractant and stripping liquid are 2.0m / min, 0.3m / min, 1.0m / min, and membrane extraction time is 8 hours Collect the back extract about 800kg; concentrate the back extract to 50kg under reduced pressure, adjust the pH to 2 with hydrochloric acid, precipitate, wash the precipitate w...

Example Embodiment

[0048] Example 3

[0049] Take 50kg of licorice, add 0.75% ammonia water for 24 times reflux extraction, extract 1 hour each time, extract 3 times, and combine to obtain 1100kg of extract; the extract is ultrafiltered with a ceramic membrane with a pore size of 10nm, and the ultrafiltration permeate is collected about 1050kg , Adjust the pH to 6 with hydrochloric acid, use 20% trialkylphosphine oxide-sulfonated kerosene as the extractant, 0.07% NaOH solution as the stripper, and extract the ultrafiltration permeate according to the specific implementation steps of the present invention. , The membrane extraction temperature is 25°C, the stripping temperature is 40°C, the flow speeds of the ultrafiltrate, extractant, and stripping liquid are 1.0m / min, 0.3m / min, 0.65m / min, respectively. The total amount of membrane extraction and stripping liquid After 12 hours, the stripping solution is about 1000kg; the stripping solution is adjusted to pH 4 with hydrochloric acid, passed through...

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Abstract

The invention discloses a method for chemically extracting purified water-soluble natural organic substances by a solid film. Based on an ultra-filtration-solid film extraction coupling technique, chemical extraction is combined with the ultra-filtration-solid film extraction coupling technique, so that chemical reaction among chemical extraction agents and functional groups of separated substances is implemented to form an extraction complex which can dissolve in an organic phase and is transferred to the organic phase, high separating selectivity is achieved, existence forms of the separatedsubstances in a water phase and the organic phase are different, the concentrations of the separated substances in an oil phase and the water phase and distribution coefficients of the separated substances in the oil phase and the water phase are unrelated, and the extraction rate of the separated substances is only related to the solubility degree of the extraction complex in the organic phase,so that the method can efficiently extract target material plant extracts with low concentration. The method is used for membrane extraction processes, ultra-filtration liquid, back-extracts and extracts are consistently cycled, more efficient and accurate extraction is achieved, and industrial operation is easily implemented.

Description

technical field [0001] The present invention relates to a method for purifying and separating water-soluble plant extracts, in particular to a method for solid film chemical extraction, purification and separation of water-soluble natural organic substances, which is mainly used in water such as alkaloids, flavonoids, anthraquinones and organic acids in plants. The invention discloses a method for separating and purifying natural organic substances with high solubility, belonging to the technical field of natural substance separation. Background technique [0002] Organic substances such as alkaloids, flavonoids, anthraquinones, and organic acids in plants often have multiple utilization values. After these substances are extracted from plants, in most cases, they need to be further separated and purified to improve their purity for easy utilization. At present, chromatography, precipitation, membrane separation, and liquid-liquid extraction are mainly used in industry for s...

Claims

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Application Information

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IPC IPC(8): B01D11/04
Inventor 魏舒畅
Owner GANSU UNIV OF CHINESE MEDICINE
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