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Compound tranexamic acid composition and preparation method and product thereof

A technology of tranexamic acid and composition, which is applied in the field of compound tranexamic acid composition and its preparation, can solve problems such as unsatisfactory effect of whitening products, and achieve the effects of improving transdermal absorption effect, overcoming poor stability and improving stability

Pending Publication Date: 2019-05-17
广州纳丽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the unsatisfactory effect of existing whitening products, an embodiment of the present invention provides a compound tranexamic acid composition on the one hand, including the following components in weight percentage: 0.6-4.0% tranexamic acid, 0.4-4.0% sodium ascorbyl phosphate 3.0%, Hydroxycyclodextrin 3.0-49.0%, the balance is water

Method used

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  • Compound tranexamic acid composition and preparation method and product thereof
  • Compound tranexamic acid composition and preparation method and product thereof

Examples

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no. 1 example

[0021] Components of the compound tranexamic acid solution (1000 parts by mass, each containing 3% tranexamic acid) of the embodiment of the present invention: 15 parts of tranexamic acid, 7 parts of sodium ascorbyl phosphate, 70 parts of hydroxycyclodextrin, 20 parts of glycerin 20 parts of propylene glycol, 30 parts of butylene glycol, 15 parts of sodium pyrrolidone carboxylate, 6 parts of phenoxyethanol, 5 parts of methylparaben and 812 parts of water.

[0022] Its preparation method is:

[0023] (1) Put sodium ascorbyl phosphate and hydroxycyclodextrin in 408 parts of water at a temperature of 40°C, stir until dissolved, and continue stirring for 0.5 hours.

[0024] (2) Add tranexamic acid into the above stirring solution, continue stirring for 1.5 hours, then add glycerin, propylene glycol, butanediol, sodium pyrrolidone carboxylate, phenoxyethanol and methylparaben, stir until dissolved, and obtain.

[0025] In the embodiment of the present invention, the inclusion comp...

no. 2 example

[0028] Components of the compound tranexamic acid solution (1000 parts by mass, each containing 1% tranexamic acid) of the embodiment of the present invention: 5 parts of tranexamic acid, 3 parts of sodium ascorbyl phosphate, 24 parts of hydroxycyclodextrin, 20 parts of glycerin 20 parts of propylene glycol, 30 parts of butylene glycol, 15 parts of sodium pyrrolidone carboxylate, 6 parts of phenoxyethanol, 5 parts of methylparaben and 872 parts of water.

[0029] Its preparation method is:

[0030] (1) Put sodium ascorbyl phosphate and hydroxycyclodextrin in 468 parts of water at a temperature of 25° C., stir until dissolved, and continue stirring for 0.5 hour.

[0031] (2) Add tranexamic acid to the above stirring state solution, continue to stir for 0.5 hours, then add glycerin, propylene glycol, butanediol, sodium pyrrolidone carboxylate, phenoxyethanol, methylparaben and remaining water, and stir until dissolved , that is.

no. 3 example

[0033] Components of the compound tranexamic acid gel (1000 parts by mass, each containing 1.5% tranexamic acid) of the embodiment of the present invention: 7.5 parts of tranexamic acid, 12 parts of sodium ascorbyl phosphate, 160 parts of hydroxycyclodextrin, glycerin 20 parts, 20 parts of propylene glycol, 30 parts of butylene glycol, 15 parts of sodium pyrrolidone carboxylate, 6 parts of phenoxyethanol, 5 parts of methyl paraben, 9 parts of hyaluronic acid, 1 part of hypromellose and water 714.5 copies.

[0034] The compound tranexamic acid gel formulation of the present invention includes but not limited to facial cleanser, face cream, moisturizing cream, massage cream, eye cream, body cream, skin cleanser, cleanser, cleansing foam, body lotion, rinse, gel , creams, masks, ointments and other beauty creams.

[0035] Its preparation method is:

[0036] (1) Put sodium ascorbyl phosphate and hydroxycyclodextrin in 320 parts of water at a temperature of 30° C., stir until dis...

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Abstract

The invention discloses a compound tranexamic acid composition. The compound tranexamic acid composition is prepared from, by weight, 0.6-4.0% of tranexamic acid, 0.4-3.0% of sodium ascorbyl phosphate, 3.0-49.0% of hydroxyl cyclodextrin and balance water. In addition, the invention further discloses a preparation method and product of the compound tranexamic acid composition. The prepared compoundtranexamic acid composition can effectively improve the percutaneous absorption effect of the tranexamic acid and sodium ascorbyl phosphate, can also improve the stability of the sodium ascorbyl phosphate in a liquid, and play a synergistic role in spot fading better.

Description

technical field [0001] The invention relates to the technical fields of daily chemical industry and medicine, in particular to a compound tranexamic acid composition, a preparation method and a product thereof. Background technique [0002] Since the emergence of human civilization, there has been the pursuit of beautification. Oriental women yearn for and pursue healthy and fair skin. In ancient China, "everyone has the love of beauty", and in modern times, "one white covers three ugliness". aesthetics. The color of human skin is mainly determined by the quantity, size and distribution of melanin contained in skin cells. Melanin is a protein present in the basal layer of everyone's skin. The irradiation of ultraviolet rays will change the melanin to produce a substance that protects the skin, and then the melanin moves through the layers of cell metabolism to the epidermis of the skin, forming skin problems such as spots and uneven skin tone that we see. [0003] In orde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/44A61K8/73A61Q19/02
Inventor 陈彦彪唐骢陈莉诗陈殿伟房俊英王锦涛
Owner 广州纳丽生物科技有限公司
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