Improved synthesis method of orotic acid

A synthetic method, orotic acid technology, applied in the direction of organic chemistry, can solve the problems of non-compliance with environmental protection requirements, use of dangerous reagents, high cost of raw materials, etc., achieve continuous operation of specific surface area, increase of reaction yield, and reduce production cost Effect

Inactive Publication Date: 2019-05-17
CHENGDU BAISHIXING SCI & TECH IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the shortcomings of this process plan are that the production cost is high, there are many three wastes, and the bromine residue in the product is high, which seriously restricts its application in the high-end market
[0009]

Method used

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  • Improved synthesis method of orotic acid
  • Improved synthesis method of orotic acid

Examples

Experimental program
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Effect test

experiment example 1

[0033] A kind of improved synthetic method of orotic acid:

[0034] S1. Control the temperature in the reaction channel at 115-120°C, adjust the flow rate of the double pumps, and pump 1.5 kg of hydantoin, 10 kg of water, 2.5 kg of 50% glyoxylic acid mixed solution and 7.5 liters of 8N sodium hydroxide solution at the same time After 2 hours of heating cycle reaction, stop heating. When the temperature drops to 70-80°C, transfer the reaction solution to a 50-liter purification reactor, maintain the internal temperature at 60-65°C, and add concentrated hydrochloric acid dropwise to adjust the pH to 9 -9.5, centrifuge the precipitated solid to obtain a crude product of off-white sodium orotate, add the crude product to 6 liters of water, keep warm at 60-65°C, add concentrated hydrochloric acid to adjust the pH to 1-2, stir for half an hour, and The centrifugation of the solid that separates out obtains 3 kilograms of orotic acid crude product;

[0035] S2. Add the above crude s...

experiment example 2

[0037] A kind of improved synthetic method of orotic acid:

[0038] S1. Control the temperature in the reaction channel at 100-110°C, adjust the flow rate of the double pumps, and pump 1.5 kg hydantoin, 10 kg water, 2.5 kg 50% glyoxylic acid mixed solution and 7.5 liters of 8N sodium hydroxide at the same time Solution, after heating and circulating for 5 hours, stop heating, and when the temperature drops to 70-80°C, transfer the reaction solution to a 50-liter purification reactor, maintain the internal temperature at 50-60°C, and add concentrated hydrochloric acid dropwise to adjust the pH to 9-9.5, centrifuge the precipitated solid to obtain a crude product of off-white sodium orotate, add the crude product to 5 liters of water, keep it warm at 60-65°C, add concentrated hydrochloric acid dropwise to adjust the pH to 1-2, and stir for half an hour, The precipitated solid is centrifuged to obtain 2.8 kilograms of orotic acid crude product;

[0039]S2. Add the above crude so...

experiment example 3

[0041] A kind of improved synthetic method of orotic acid:

[0042] S1. Control the temperature in the reaction channel at 110-115°C, adjust the flow rate of the double pumps, and pump 1.5 kg of hydantoin, 10 kg of water, 2.5 kg of 50% glyoxylic acid mixed solution and 7.5 liters of 8N sodium hydroxide at the same time Solution, after heating and circulating for 2 hours, stop heating, and when the temperature drops to 70-80°C, transfer the reaction solution to a 50-liter purification reactor, maintain the internal temperature at 60-65°C, and add concentrated hydrochloric acid dropwise to adjust the pH to 9-9.5, centrifuge the precipitated solid to obtain a crude product of off-white sodium orotate, add the crude product to 5 liters of water, keep it warm at 60-65°C, add concentrated hydrochloric acid dropwise to adjust the pH to 1-2, and stir for half an hour, The precipitated solid is centrifuged to obtain 2.95 kilograms of orotic acid crude product;

[0043] S2. Add the abo...

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Abstract

The invention discloses an improved synthesis method of orotic acid and belongs to the field of organic chemical synthesis. The improved synthesis method comprises the following steps: heating a watersolution of hydantoin, glyoxylic acid and sodium hydroxide in a specific micro-channel reactor and reacting to obtain an orotic acid crude product; after refining the crude product, obtaining an orotic acid pure product. According to the improved synthesis method, a whole production process is carried out in the micro-channel reactor, so that the reaction conversion rate and the yield are improved and the reaction yield reaches 90 percent or above.

Description

technical field [0001] The invention belongs to the field of organic chemistry, and in particular relates to an improved synthesis method of orotic acid. Background technique [0002] Orotic acid, also known as vitamin B13, the ketone name is 1,2,3,4-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid, and the enol name is 2,6- Dihydroxypyrimidine-4-carboxylic acid, as an effective precursor in the biosynthesis of pyrimidine-based nucleic acids in living organisms, is an important pyrimidine derivative that plays a unique role in biological and medicinal chemistry. [0003] Orotic acid and its derivatives are widely used in the field of medicine. Orotic acid is used as an important drug in the treatment of liver diseases for the treatment of icteric liver disease and general liver dysfunction. Drug molecules participated in by orotic acid group play an important active role in the treatment of myocardial infarction, gastric ulcer, Mycobacterium tuberculosis and so on. In lif...

Claims

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Application Information

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IPC IPC(8): C07D239/557
Inventor 石常青
Owner CHENGDU BAISHIXING SCI & TECH IND
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