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A quality detection method and application of a traditional Chinese medicine composition for invigorating the kidney and soothing the spine

A quality inspection method and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., can solve the problems of detection and monitoring of traditional Chinese medicine compositions, various flavors of traditional Chinese medicines, and inability to interfere with each other, and achieve specificity Strong, easy to master, achieves quality results

Active Publication Date: 2022-02-22
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by the present invention is to provide a quality detection method and its application of a traditional Chinese medicine composition for invigorating the kidney and relaxing the spine, which overcomes the inability to comprehensively and clearly identify the traditional Chinese medicine due to its various flavors, complex components and mutual interference. The quality of the traditional Chinese medicine composition is detected and monitored, and the stability, consistency and controllability of the quality of the traditional Chinese medicine composition are improved

Method used

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  • A quality detection method and application of a traditional Chinese medicine composition for invigorating the kidney and soothing the spine
  • A quality detection method and application of a traditional Chinese medicine composition for invigorating the kidney and soothing the spine
  • A quality detection method and application of a traditional Chinese medicine composition for invigorating the kidney and soothing the spine

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Experimental program
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Effect test

Embodiment 1

[0070] Embodiment 1 Granules

[0071] Prescription: Rhizoma Drynariae 10g, Gouji 6g, Eucommia 6g, Guizhi 6g, Antler 4g, Corydalis Corydalis 7g, Dipsacus 7g, Gentiana chinensis 7g, Qingfengteng 9g and Notopterygium 6g;

[0072] Preparation method: Weigh Drynaria fortunei, Gouji, Eucommia, Guizhi, Antler, Corydalis Corydalis, Dipsacus, Gentiana chinensis, Qingfengteng and Qianghuo according to the selected parts by weight, and set aside; take Guizhi and Qianghuo two flavors, add 10 times Measure the water, steam distill for 6 hours, extract the volatile oil, collect the volatile oil, filter the water extract, and set aside; according to the volatile oil, β-cyclodextrin and water as 1ml: 6g: 60ml, add β-cyclodextrin and water to the volatile oil , stirred, clathrated for 30 minutes, refrigerated for 24 hours, filtered with suction, dried at 40°C to obtain clathrates of volatile oil, and set aside; take dog ridge, Eucommia ulmoides, antlers, and Dipsacus four flavors, add water an...

Embodiment 2

[0079] Embodiment 2 Granules

[0080] Prescription: Rhizoma Drynariae 8g, Dogji 4g, Eucommia 4g, Guizhi 4g, Antler 2g, Corydalis Corydalis 5g, Dipsacus 5g, Gentiana chinensis 5g, Qingfengteng 7g and Notopterygium 4g;

[0081] Preparation method: Weigh Drynaria fortunei, Gouji, Eucommia ulmoides, Guizhi, antlers, Corydalis Corydalis, Dipsacus, Gentiana chinensis, Qingfengteng and Qianghuo according to the selected parts by weight, and set aside; take Guizhi and Qianghuo, add 12 times Measure the water, steam distill for 4 hours, extract the volatile oil, collect the volatile oil, filter the water extract, and set aside; according to the volatile oil, β-cyclodextrin and water as 1ml: 4g: 80ml, add β-cyclodextrin and water to the volatile oil , inclusion compound for 60 minutes, refrigerated for 12 hours, suction filtered, dried at 50°C to obtain volatile oil inclusion compound, and set aside; take dog spine, Eucommia, antler, and Dipsacus four flavors, add water to decoct once, ...

Embodiment 3

[0088] Embodiment 3 granules

[0089] Composition: Rhizoma Drynariae 12g, Dogji 8g, Eucommia 8g, Guizhi 8g, Antler 6g, Corydalis Corydalis 9g, Dipsacus 9g, Gentiana 9g, Qingfengteng 11g and Notopterygium 8g;

[0090] Preparation method: Weigh Drynaria fortunei, Gouji, Eucommia, Guizhi, Antler, Corydalis Corydalis, Dipsacus, Gentiana chinensis, Qingfengteng and Qianghuo according to the selected parts by weight, and set aside; take Guizhi and Qianghuo, add 8 times Measure water, steam distill for 8 hours, extract volatile oil, collect volatile oil, filter the water extract, and set aside; according to the ratio of volatile oil, β-cyclodextrin and water: 1ml: 10g: 40ml, add β-cyclodextrin and water to the volatile oil , inclusion compound for 20 minutes, refrigerated for 48 hours, suction filtered, and dried at 30°C to obtain a volatile oil inclusion compound, which is then used for later use; take dog ridge, Eucommia ulmoides, antlers, and Dipsacus four flavors, add water to de...

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Abstract

The invention provides a detection method of a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials by weight: 8-12 parts of Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, 4-8 parts of Eucommia ulmoides, 4-8 parts of Guizhi 4‑8 parts, 2‑6 parts of Antler, 5‑9 parts of Corydalis Corydalis, 5‑9 parts of Dipsacus, 5‑9 parts of Gentiana chinensis, 7‑11 parts of Qingfengteng and 4‑8 parts of Notopterygium, determined by limited multiple screening A suitable extraction method or purification method is used to prepare the test solution, and the HPLC method is used to select suitable chromatographic conditions to effectively separate the active ingredients in the Chinese medicine composition from other impurities, and accurately determine the active ingredients of the Chinese medicine composition. The content of dermatosin and sinomenine; Utilize TLC method, select suitable developing agent, realize the identification of Corydalis Corydalis, Gentiana and notopterygium in Chinese medicine composition, the method accuracy of the present invention, sensitivity are high, and detection range is wide, realizes effective control of drug quality.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a quality detection method and application of a traditional Chinese medicine composition for invigorating the kidney and relaxing spine. Background technique [0002] Ankylosing spondylitis (AS) is a chronic progressive immune inflammatory disease of unknown cause, which mainly invades axial joints such as sacroiliac joints, spinal condyles, paraspinal soft tissues and peripheral joints, and may be accompanied by external performance. The main clinical manifestations are lumbosacral, back, neck, buttock, hip pain and joint swelling and pain. In severe cases, spinal deformity and joint stiffness may occur, affecting the patient's physical and mental health, and affecting the eyes, heart, lungs, kidneys and other organs. High disability rate. [0003] The treatment principle of the domestic guideline believes that there is no radical cure for ankylosing sp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02A61K36/66A61K47/69A61P19/00A61P19/02A61P29/00A61P37/02G01N30/06G01N30/90A61K35/32
Inventor 解素花段瑞刚杜菁张蓓
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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