Single oxygen controlled-release carbon quantum dots and preparation method and application thereof

A technology of carbon quantum dots and singlet oxygen, which is applied in the field of singlet oxygen controlled-release carbon quantum dots and its preparation, achieving the effects of simple and easy preparation methods, good biocompatibility, and improved encapsulation efficiency

Active Publication Date: 2019-05-24
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CDs contain a large amount of sp 2 carbon, which can be efficiently captured 1 o 2 , presently about controllable capture and release 1 o 2 The research on the preparation and application of CDs is still blank

Method used

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  • Single oxygen controlled-release carbon quantum dots and preparation method and application thereof
  • Single oxygen controlled-release carbon quantum dots and preparation method and application thereof
  • Single oxygen controlled-release carbon quantum dots and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Select straw as the carbon source to implement the experiment, including the following steps:

[0038] Step 1, preparation of CDs: Put the crushed dry straw into a hydrothermal reaction kettle, add 40mL of water, and heat at 180°C for 12h. After cooling to room temperature, the filtrate was filtered, centrifuged at 16000 rpm for 15 min, and finally dialyzed with ultrapure water to obtain pure CDs aqueous solution.

[0039] Step 2, mixing CDs with a photosensitizer: Add 40ml of the prepared CDs aqueous solution and 1ml of the photosensitizer rose bengal solution into a round bottom flask at room temperature, and stir the mixture at room temperature for 0.5h.

[0040] Step 3, detection of CDs captured 1 o 2 Ability: Divide 40mL prepared mixture of CDs and photosensitizer into 8 equal parts, each group undergoes different light time: 0, 10min, 20min, 30min, 1h, 1.5h, 2h, 2.5h. Then the solutions of each group after illumination were removed by filtration, centrifugation...

Embodiment 2

[0047] Select seaweed as the carbon source to implement the experiment, including the following steps:

[0048] Step 1, preparation of CDs: Put the pulverized dry seaweed into a hydrothermal reaction kettle, add 40mL of water, and heat at 180°C for 12h. After cooling to room temperature, the filtrate was filtered, centrifuged at 16000 rpm for 15 min, and finally dialyzed with ultrapure water to obtain pure CDs aqueous solution.

[0049] Step 2, mixing CDs with a photosensitizer: Add 40ml of the prepared CDs aqueous solution and 1ml of the photosensitizer rose bengal solution into a round bottom flask at room temperature, and stir the mixture at room temperature for 0.5h.

[0050] Step 3, detection of CDs captured 1 o 2 Ability: Divide 40mL prepared CDs and photosensitizer mixture evenly into 8 equal parts, each group undergoes different light time: 0, 10min, 20min, 30min, 1h, 1.5h, 2h, 2.5h. Then the solutions of each group after illumination were removed by filtration, cen...

Embodiment 3

[0057] Select banana peel as the carbon source to implement the experiment, including the following steps:

[0058] Step 1, preparation of CDs: grind dried banana peels, put a certain amount into a hydrothermal reaction kettle, add 40mL of water, and heat at 180°C for 12h. After cooling to room temperature, the filtrate was filtered, centrifuged at 16000 rpm for 15 min, and finally dialyzed with ultrapure water to obtain pure CDs aqueous solution.

[0059] Step 2, mixing CDs with a photosensitizer: Add 40ml of the prepared CDs aqueous solution and 1ml of the photosensitizer rose bengal solution into a round bottom flask at room temperature, and stir the mixture at room temperature for 0.5h.

[0060] Step 3, detection of CDs captured 1 o 2 Ability: Divide 40mL prepared CDs and photosensitizer mixture evenly into 8 equal parts, each group undergoes different light time: 0, 10min, 20min, 30min, 1h, 1.5h, 2h, 2.5h. Then the solutions of each group after illumination were remove...

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Abstract

The invention relates to the field of new materials for cancer treatment, in particular to singlet oxygen (1O 2) controlled-release carbon quantum dots (CDs) and a preparation method and application thereof. The CDs have a strong ability of capturing 1O 2, and can release the captured CO2 under heating or ultrasound conditions for efficient treatment of hypoxic tumors. At the same time, the CDs have the advantages that the photothermal conversion efficiency is high, the photostability and biocompatibility are excellent, the synthesis process is simple, raw materials are easy to obtain, and thecost is low, and the single oxygen controlled-release carbon quantum dots can be used as new materials for cancer treatment.

Description

technical field [0001] The invention belongs to the field of malignant tumor treatment, in particular to a singlet oxygen controlled-release carbon quantum dot and its preparation method and application. Background technique [0002] According to the World Health Organization, cancer caused 8.8 million deaths in 2015. Globally, nearly 1 / 6 of deaths are caused by cancer. Therefore, cancer treatment is particularly important in improving human health. Traditional tumor treatment methods include surgery, radiotherapy, and chemotherapy. These treatment methods have relatively large trauma or toxic side effects for patients, and often have poor therapeutic effects. Photodynamic therapy (PDT) is a new type of non-invasive treatment. Its principle is to inject a photosensitizer into the body, and after a certain period of time, irradiate the lesion with light of a specific wavelength. After a series of photochemical reactions, the singlet oxygen ( 1 o 2 ) can oxidize and destr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00A61K41/00A61P35/00
Inventor 蓝敏焕胥婷赵少静符燕召
Owner CENT SOUTH UNIV
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