Fully-biodegradable zinc alloy tracheal scaffold matched with tracheal physiological structure

Abstract

The invention belongs to the fields of medical instruments and tracheal bronchus disease interventional therapy, and particularly relates to a coverable medicine-carrying balloon expanding fully-biodegradable zinc alloy tracheal scaffold. According to the scaffold, bionic structure design is adopted, the scaffold is perfectly matched with a tracheal anatomical structure, and a covered or non-covered mode can be adopted for treating tracheal orificium fistulae or tracheal blocking. A tracheal scaffold base material is zinc alloy, and the zinc alloy has full degradation performance, so that secondary removal is avoided; through CT (computed tomography), the morphology of the trachea of the patient is obtained, then through data processing, a tracheal normal physiological anatomical structureis restored, anteroposterior diameter, mediolateral diameter, the height of C-type cartilage and the ligament height of the tracheal of the patient in a normal situation are measured, after data is obtained, a 3D printing technology is used for producing a tracheal scaffold prototype, and a laser engraving technology is used for forming microgrooves or micropores in the surface of the scaffold for medicine carrying so that granulation tissue proliferation can be inhibited.

Description

technical field [0001] The invention belongs to the field of medical equipment and interventional treatment of tracheobronchial diseases, and in particular relates to a fully degradable zinc alloy tracheal stent that can be expanded with a film-coated drug-loaded balloon. Background technique [0002] Tracheal stenosis caused by tracheal tumor or trauma can induce many tracheal diseases, such as tracheal stenosis caused by tracheal tumor or tracheal fistula caused by tracheal trauma, which will affect life in severe cases. Tracheal stent implantation is an important interventional therapy for the treatment of tracheal diseases. However, tracheal stent implantation generally faces problems such as stent displacement, granulation tissue hyperplasia, mucosal obstruction, stent fracture, and secondary removal. [0003] The materials currently used in degradable tracheal stents are mainly synthetic polymer materials such as polydioxanone (Zilberman M, 2005) and poly-L-lactic aci...

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Problems solved by technology

However, tracheal stent implantation generally faces problems such as stent displacement, granulation tissue hyperplasia, mucosal obstruction, stent fracture, and secondary removal.

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