Two indole new alkaloid compounds in purslane and extraction and separation method and application thereof

A separation method and technology of indoles, applied in the direction of drug combination, organic chemistry, non-central analgesics, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2019-05-31
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural

Method used

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  • Two indole new alkaloid compounds in purslane and extraction and separation method and application thereof
  • Two indole new alkaloid compounds in purslane and extraction and separation method and application thereof
  • Two indole new alkaloid compounds in purslane and extraction and separation method and application thereof

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Embodiment 1

[0043] The present invention provides two kinds of new indole alkaloid compounds, the molecular formulas are respectively C 17 h 13 NO 4 , C 18 h 15 NO 5 , named oleraindole A and oleraindole B, the chemical structural formula is:

[0044]

[0045] The two alkaloid compounds are named oleraindole A and oleraindole B according to the structure, and Table 1 is the NMR data of the two alkaloid compounds: 1 H-NMR with 13 C-NMR in DMSO.

[0046] Table 1: NMR data of new alkaloid compounds oleraindole A and oleraindole B of the present invention

[0047]

[0048] The structure identification and deduction of a new alkaloid compound oleraindole A of the present invention.

[0049] Oleraindole A: yellow powder, easily soluble in methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute potassium bismuth iodide test solution appear orange-yellow, suggesting that the compound is an alkaloid componen...

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Abstract

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to two indole new alkaloid compounds extracted, separated and identified from purslane, andan extraction and separation method and application thereof.The molecular formulas of the two new indole alkaloid compounds separated from purslane medicinal materials are respectively C17H13NO4 and C18H15NO5, and are respectively named as oleraindole A and oleraindole B.The invention also provides theextraction and separation method of the two new alkaloid compounds, which comprises the followingsteps of: sequentially adopting water decoction and extraction, silica gel column chromatography, polyamide column chromatography, ODS medium pressure column, and Sephadex LH-20 purification and liquid phase separation to preparethe two new alkaloid compounds. The structure of thetwo new alkaloid compounds is determined by ultraviolet, infrared, mass spectrum, hydrogen spectrum, carbon spectrum and two-dimensional nuclear magnetic spectrum analysis.The two indole new alkaloid compounds extracted from the purslane have anti-inflammatory, anti-tumor and nerve protection effects, and the salt orderivative of thetwo indole new alkaloid compounds can be used as a leading substance for synthesizing other compounds, as well as raw materials for new drug development and pharmacological activityresearch, and can be used for preparing anti-inflammatory, anti-tumor and nerve protection drugs.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new alkaloid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat and detoxification, cooling blood and stopping bleeding, an...

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Application Information

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IPC IPC(8): C07D209/08A61P29/00A61P35/00A61P25/00
Inventor 英锡相赵程程张文洁马懿飞
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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