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Terbinafine hydrochloride-flavored tablet for dogs and cats and preparation process thereof

A technology of terbinafine hydrochloride and nafine tablets, which is applied in the direction of medical preparations containing active ingredients, pill delivery, organic active ingredients, etc., can solve the problems of low blood drug effective concentration, long recovery time, easy recurrence, etc. Achieve the effects of reducing the frequency and number of medications, prolonging the effective concentration time, and reducing bitterness and astringency

Inactive Publication Date: 2019-06-04
天津市保灵动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In veterinary clinical practice, fungal venereal disease in dogs and cats is a very common and frequently-occurring disease, with an average incidence rate of about 10%-40%. Mutual transmission between humans, humans and animals has caused serious public health problems. Terbinafine hydrochloride has a broad antibacterial spectrum and strong bactericidal power. Bacteria are particularly sensitive, and clinical applications are increasingly widespread. Since it was launched in 1991, it has been verified by human clinical practice for nearly 20 years. It is a very good antifungal drug with few adverse reactions and low toxicity. Bitter, dogs and cats do not want to take it, currently veterinary clinics mainly use sprays and ointments for external use, but they have very poor effects on deep skin, intestinal tract, and ear fungal infections; on the other hand, the existing hydrochloric acid for dogs and cats The stability of Binafine Tablets is poor, resulting in low blood drug effective concentration, long recovery time, and a large amount of time and dosage for taking the drug. Therefore, veterinary clinics need an oral antifungal drug that dogs and cats are willing to accept and has high bioavailability

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0021] A preparation process for terbinafine hydrochloride flavor tablets for dogs and cats, comprising the following steps:

[0022] (1) Weigh the polymer complexing agent, heat and melt it, add terbinafine hydrochloride tablets to make a suspension, through the fusion with the polymer complexing agent, improve the stability of terbinafine hydrochloride, and prolong the effective period of blood medicine concentration time;

[0023] (2) After heating and melting the palatable agent into a clear and transparent liquid, add it to the suspension, heat-preserve and spray at 90°C-100°C, freeze-dry to obtain 40-mesh microcapsule particles;

[0024] (3) dissolving the polyacrylic acid resin Type II with absolute ethanol, placing the microcapsule particles in the step (2) in a fluidized bed for bottom spray coating to obtain odorless terbinafine hydrochloride granules;

[0025] (4) Take the odorless terbinafine hydrochloride granules in step (3), add flavoring agent, mix well, make ...

Embodiment 1

[0027] Step 1: Weigh polyethylene glycol 15-hydroxystearate and heat and melt it, then add terbinafine hydrochloride to make a suspension to prolong the effective blood drug concentration; Step 2: heat and melt stearic acid to form a clear After the liquid, add the suspension in the first step, heat-preserve and spray at 90-100°C, and freeze-dry to obtain microcapsule particles of about 40 meshes; in the third step, dissolve the polyacrylic acid resin type II with absolute ethanol, and dissolve the polyacrylic resin type II in the step (2 ) Microcapsule granules are placed in a fluidized bed and carried out bottom spray coating to obtain tasteless terbinafine hydrochloride granules; the fourth step is to get the granules in step (3) and add lactose, chicken powder, sodium carboxymethyl starch, mix well, and prepare Soft material, passed through a 20-mesh sieve to granulate, dried, granulated through a 24-mesh sieve; added magnesium stearate, mixed evenly, and pressed into table...

Embodiment 2

[0029] Step 1: Weigh polyethylene glycol 15-hydroxystearate and heat and melt it, then add terbinafine hydrochloride to make a suspension to prolong the effective blood drug concentration; Step 2: Take glyceryl stearate and heat and melt After becoming a clear liquid, add the suspension in the first step, heat-preserve and spray at 90-100°C, and freeze-dry to obtain microcapsule particles of about 40 meshes; in the third step, dissolve polyacrylic acid resin type II with absolute ethanol, and (2) the microcapsule particles are placed in a fluidized bed for bottom spray coating to obtain tasteless terbinafine hydrochloride granules; the fourth step is to take the granules of step (3) and add lactose, chicken powder, sodium carboxymethyl starch, and mix evenly. Make soft material, pass through a 20-mesh sieve to granulate, dry, and granulate with a 24-mesh sieve; add magnesium stearate, mix evenly, and compress into tablets.

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PUM

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Abstract

The invention provides a terbinafine hydrochloride-flavored tablet for dogs and cats. The tablet comprises the following components in percentage by weight: 5-10% of terbinafine hydrochloride tablets,25-50% of a polymer complexing agent, 5-10% of a palatability agent, 10-20% of polyacrylic resin type II, 50-70% of a flavoring agent and 2-5% of magnesium stearate. According to the invention, the polymer complexing agent and the terbinafine hydrochloride tablets are subjected to complexing treatment, so that the stability of terbinafine hydrochloride is improved and the effective plasma concentration time is improved. Meanwhile, the palatability agent and the flavoring agent are added, so that the tablet is easier to take by dogs and cats. The invention also provides a preparation process of the terbinafine hydrochloride-flavor tablet for dogs and cats.

Description

technical field [0001] The invention belongs to the technical field of pet medicine, and in particular relates to a terbinafine hydrochloride flavor tablet for dogs and cats and a preparation process thereof. Background technique [0002] In veterinary clinical practice, fungal venereal disease in dogs and cats is a very common and frequently-occurring disease, with an average incidence rate of about 10%-40%. Mutual transmission between humans, humans and animals has caused serious public health problems. Terbinafine hydrochloride has a broad antibacterial spectrum and strong bactericidal power. Bacteria are particularly sensitive, and clinical applications are increasingly widespread. Since it was launched in 1991, it has been verified by human clinical practice for nearly 20 years. It is a very good antifungal drug with few adverse reactions and low toxicity. Bitter, dogs and cats do not want to take it, currently veterinary clinics mainly use sprays and ointments for ext...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/137A61P31/10
Inventor 许新增郭长林刘福全
Owner 天津市保灵动物保健品有限公司