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Method for preparing intraocular lens for preventing after-cataract based on photothermal conversion

A technology of intraocular lens and light-to-heat conversion, which is applied in the direction of medical preparations containing active ingredients, prostheses, pharmaceutical formulas, etc., can solve the problems of limited preventive effect, achieve less side effects, inhibit proliferation and migration, and have good penetration Effect

Inactive Publication Date: 2019-06-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical data show that the only way that can really effectively prevent post-developmental disorders is to use hydrophobic materials and square-edged intraocular lenses, and the preventive effect of this method is still limited

Method used

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  • Method for preparing intraocular lens for preventing after-cataract based on photothermal conversion
  • Method for preparing intraocular lens for preventing after-cataract based on photothermal conversion
  • Method for preparing intraocular lens for preventing after-cataract based on photothermal conversion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Add 150 mg of glucose, 200 mg of dopamine hydrochloride and 300 μL of hydrogen peroxide to 100 mL of Tris-HCl buffer solution at pH=8.5 in sequence to prepare a dopamine buffer solution. The intraocular lens (with C-shaped loop) whose optical zone has been covered with a polydimethylsiloxane (PDMS) film was placed in the above-mentioned dopamine buffer solution for reaction, shaken at a constant speed for 30 minutes at room temperature on a constant temperature shaker, and then taken out. Remove the PDMS film on the surface, rinse with ultrapure water for 3 to 5 times, blow dry with nitrogen, and store in the dark.

[0037] The intraocular lens with light-to-heat conversion function prepared by this method, such as image 3 As shown, under the irradiation of near-infrared light with a wavelength of 808 nm, the non-optical region can rapidly heat up to about 50 °C within 3 minutes. Turn off the near-infrared light irradiation, and the temperature of the non-optical area...

Embodiment 2

[0039] Add 15 mg of sodium sulfite, 200 mg of dopamine hydrochloride and 20 mg of potassium persulfate to 100 mL of Tris-HCl buffer solution at pH=8.5 in sequence to prepare a dopamine buffer solution. The intraocular lens (with plate-shaped loops) whose optical zone has been covered with a polydimethylsiloxane (PDMS) film was placed in the above-mentioned dopamine buffer solution for reaction, shaken at a constant speed for 10 minutes at room temperature on a constant temperature shaker, and then taken out. Remove the PDMS film on the surface, rinse with ultrapure water for 3 to 5 times, blow dry with nitrogen, and store in the dark.

[0040] The intraocular lens with photothermal conversion function prepared by this method can rapidly raise the temperature of its non-optic region to about 55° C. within 4 minutes under the irradiation of near-infrared light with a wavelength of 808 nm. Turn off the near-infrared light irradiation, and the temperature of the non-optical area o...

Embodiment 3

[0042] Add 125 mg of copper sulfate pentahydrate, 200 mg of dopamine hydrochloride and 200 μL of hydrogen peroxide to 100 mL of Tris-HCl buffer solution at pH=8.5 in sequence to prepare a dopamine buffer solution. Put the intraocular lens (with C-shaped loop) covered with polyimide film in the optical area to react in the above-mentioned dopamine buffer solution, take it out after shaking at a constant speed at room temperature for 20 minutes with a constant temperature shaker, remove the PDMS film on the surface, Rinse with ultrapure water for 3 to 5 times, blow dry with nitrogen, and store in the dark.

[0043] The intraocular lens with photothermal conversion function prepared by this method can rapidly raise the temperature of its non-optic region to about 60° C. within 4 minutes under the irradiation of near-infrared light with a wavelength of 808 nm. Turn off the near-infrared light irradiation, and the temperature of the non-optical area of ​​the intraocular lens graduall...

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Abstract

The invention relates to an intraocular lens and can provide a new way to prevent after-cataract and improve the quality of life of cataract patients. A method for preparing an intraocular lens for preventing after-cataract based on photothermal conversion comprises the following steps: (1) using a circular protective film sheet pre-trimmed into an appropriate size to cover the surface of the central optical zone of the intraocular lens; (2) preparing a dopamine buffer solution, wherein the concentration of dopamine in the dopamine buffer solution is 2-6 mg / mL, the concentration of an oxidantand a reducing agent is 5-20 mmol / L, and the balance is a buffer; (3) placing the intraocular lens in the above dopamine buffer solution for 10-50 minutes; (4) taking the intraocular lens out, removing the protective film sheet and rinsing the lens with ultrapure water for 3-5 times; (5) drying the rinsed intraocular lens with nitrogen and storing the intraocular lens in the dark.

Description

technical field [0001] The invention relates to an intraocular lens, in particular to a method for preparing an intraocular lens based on photothermal conversion to prevent post-failure. Background technique [0002] Cataract is a common eye disease characterized by clouding and degeneration of the lens. According to the World Health Organization (WHO) estimate in 2014, approximately 95 million people worldwide are affected by cataracts. The disease remains the number one cause of blindness in low- and middle-income countries. For cataracts that significantly affect vision, the current standard treatment is to crush and remove the degenerated and cloudy lens through minimally invasive surgery, and implant an intraocular lens as a replacement. [0003] Afterclaw is the most common complication after cataract surgery. According to different reports, its three-year incidence rate is about 15-28.4%. It is inevitable that there will be lens epithelial cells remaining on the eq...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/50A61K41/00A61P27/02
Inventor 姚克徐经纬
Owner ZHEJIANG UNIV
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