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Preparation method of biocompatible silk fibroin film for flexible magnetoelectric device substrate

A technology of biocompatible and magnetoelectric devices, which is applied in the field of preparation of biocompatible silk fibroin membranes, can solve the problems of inability to achieve biocompatibility, inability to biodegrade secondary recovery, etc., and achieve great production flexibility and preparation process Simple, fast and low energy consumption effect

Inactive Publication Date: 2019-06-14
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For silicon-based materials, such as polydimethylsiloxane, the need for biocompatibility cannot be met, and secondary recycling is required because it is not biodegradable

Method used

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  • Preparation method of biocompatible silk fibroin film for flexible magnetoelectric device substrate

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preparation example Construction

[0027] A method for preparing a biocompatible silk film for a substrate of a flexible magnetoelectric device, comprising the following steps:

[0028] Step 1, using natural silk as a raw material, obtain a pure silk fibroin aqueous solution by cutting, degumming, cleaning, dissolving, dialysis, and centrifugation;

[0029] Step 2, using pure silk fibroin aqueous solution as the biocompatible substrate material for making flexible magnetoelectric devices, and the concentration of silk fibroin is not lower than 5% and not higher than 15%;

[0030] Step 3, cleaning the rigid substrate, the rigid substrate includes a polymethyl methacrylate substrate, a polystyrene substrate or a mica substrate;

[0031] Step 4, coating the silk fibroin aqueous solution on the clean rigid substrate by means of spin coating, drop coating, spray coating, inkjet printing or laser printing;

[0032] Step 5, the solution-coated rigid substrate is naturally air-dried, convectively air-dried or dried; ...

Embodiment 1

[0045] 1) Use a 2L beaker to fill ultrapure water, after boiling

[0046] Add 8g of anhydrous sodium carbonate, weigh 10g of dry silk and add, cook for 20min, stir gently to remove the sericin on the silk. Then rinse with 2L of ultrapure water for 20 minutes, change the water for three times, squeeze out the water, and spread it out on aluminum foil to dry.

[0047] 2) After the silk fibroin is dried, weigh 6g of silk fibroin, corresponding to 20g of lithium bromide, and dissolve it in 25ml solution at a constant volume. Stuff the silk fibroin in the smallest possible beaker and slowly pour the lithium bromide solution into it. Dissolve in an oven at 60°C for 4 hours.

[0048]3) Take two dialysis boxes, soak them in ultrapure water for 20 minutes, insert two needles into the two corners of one side, inject 12ml silk fibroin solution through one needle, and expel the air through the other needle, and finally pull out the needle. Use a sleeve holder to float it in 2L of ultra...

Embodiment 2

[0055] 1) Use a 2L beaker to fill with ultra-pure water, add 8g of anhydrous sodium carbonate after boiling, weigh 10g of dry silk and add, boil for 20min, stir gently to remove sericin on the silk. Then rinse with 2L of ultrapure water for 20 minutes, change the water for three times, squeeze out the water, and spread it out on aluminum foil to dry.

[0056] 2) After the silk fibroin is dried, weigh 6g of silk fibroin, corresponding to 20g of lithium bromide, and dissolve it in 25ml solution at a constant volume. Stuff the silk fibroin in the smallest possible beaker and slowly pour the lithium bromide solution into it. Place in an oven at 60°C to dissolve for 4 hours.

[0057] 3) Take two dialysis boxes, soak them in ultrapure water for 20 minutes, insert two needles into the two corners of one side, inject 12ml silk fibroin solution through one needle, and expel the air through the other needle, and finally pull out the needle. Use a sleeve holder to float it in 2L of ult...

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Abstract

A preparation method of a biocompatible silk fibroin film for a flexible magnetoelectric device substrate comprises the following steps: 1, preparing a pure aqueous silk fibroin solution from naturalsilk, used as a substrate making material; 2, cleaning a rigid substrate; 3, coating the clean rigid substrate with the aqueous silk fibroin solution; 4, carrying out natural air drying, convection air drying or drying on the solution-coated rigid substrate; and 5, stripping the silk fibroin film from the surface of the rigid substrate after the water is completely evaporated in order to form theindependently supported biocompatible flexible silk fibroin film. The method using the natural silk as the raw material for preparing the flexible magnetoelectric device substrate has a simple and rapid preparation process and a high success rate, and can provide a substrate for health monitoring flexible magnetoelectric devices having great application values.

Description

technical field [0001] The invention belongs to the technical field of flexible magnetoelectric device substrates, in particular to a preparation method of a biocompatible silk film used for flexible magnetoelectric device substrates. Background technique [0002] Flexible electronics are mechanically flexible electronic devices that can adapt to complex surface shapes, including a series of smart electronic accessories and systems that can be integrated and comfortably integrated into the human body. It has a wide range of applications in flexible display, electronic skin, human body detection / treatment system, and energy. Especially in the field of health, the development of flexible electronics provides an effective tool for obtaining data on daily activities, sports performance and health status, as well as real-time accurate treatment plans: (1) through the combination of telemedicine and healthcare systems, risks can be Patients are monitored. (2) Includes smart watc...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J7/00C08L89/00
Inventor 刘明张晓慧周子尧胡忠强张淇彭斌
Owner XI AN JIAOTONG UNIV
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