Oxyclozanide and albendazole compound suspension and preparation method thereof

Abstract

The invention discloses an oxyclozanide and albendazole compound suspension. Each 100mL of the suspension comprises 4.00g of oxyclozanide, 4.00g of albendazole, 0.25g of xanthan gum, 0.20g of povidone, 3.00mL of tween-80, 1.20g of citric acid and 0.15g of sodium benzoate. The invention further discloses a preparation method of the suspension. The suspension is stable in property, high in redispersity, controllable in quality, safe, effective, conducive to industrial production, easy for quantitative use and suitable for big animal administration.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and in particular relates to a compound suspension of penclosamide and albendazole and a preparation method thereof. Background technique [0002] Penxclosamide (oxyclozanide, 2,3,5,-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide) is a salicylanilide antiparasitic Drugs, also known as losalamide, hydroxyclosalamide, hydroxyclozanamide, etc., are a kind of oxidative phosphorylation uncoupling agent, which can reduce the synthesis of adenosine triphosphate (ATP) in parasites, resulting in parasites due to energy metabolism disorders And eventually died, penclosamide not only has a good deworming effect on fasciola hepatica, but also has activity on tapeworms and nematodes. It is a broad-spectrum, low toxicity and low residue chemically synthesized drug. So far, there is no report of drug resistance, and it is the first choice for clinical anti-helminth infection. The research on pen...

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Problems solved by technology

[0002] Penxclosamide (oxyclozanide, 2,3,5,-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide) is a salicylanilide antiparasitic Drugs, also known as losalamide, hydroxyclosalamide, hydroxyclozanamide, etc., are a kind of oxidative phosphorylation uncoupling agent, which can reduce the synthesis of adenosine triphosphate (ATP) in parasites, resulting in parasites due to energy metabolism disorders And eventually died, penclosamide not only has a good deworming effect on fasciola hepatica, but also has activity on tapeworms and nematodes. It is a broad-spectrum, low toxicity and low residue chemically synthesized drug. So far there is no report of related drug resistance, it is the first choice for clinical anti-helminth infection

[0004] Since penclosamide is insoluble in water and albendazole is insoluble in both water and organic solvents, at present, the commonly used dosage form of penclosamide abroad is mainly suspension, and there is no related product in China Launched on the market; the commonly used dosage forms of albendazole are mainly tablets and capsules, which greatly limits the clinical application of the drug; at the same time, due to the long-term and large-scale use of albendazole in clinical practice, the problem of drug resistance is becoming more and more serious

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