Application of isoflavone in preparation of drug for treating fundus maculopathy

A technology for macular degeneration and isoflavones, applied in the field of biomedicine, can solve the problems of high cost and complicated operation, and achieve the effect of convenient medication, broad application prospects and significant curative effect

Inactive Publication Date: 2019-06-25
GUANGDONG WHOLEWIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the most effective treatment methods currently used are all physical therapy methods, which are expensive and complicated to operate. In terms of medication, systemic medication is difficult to accurately act on the fundus, because the microvascular diameter of the retina is very small, and the blood circulation in the body The more end position of the system

Method used

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  • Application of isoflavone in preparation of drug for treating fundus maculopathy
  • Application of isoflavone in preparation of drug for treating fundus maculopathy
  • Application of isoflavone in preparation of drug for treating fundus maculopathy

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Effect test

Embodiment 1

[0033] Choroidal neovascularization (CNV) model induced by 532nm argon laser was selected from C57 / B6 mice. (The laser point should avoid the main blood vessels and be 2.5 to 3.0 optic disc diameters away from the optic nerve head.) The mice with successful modeling were divided into two groups, each group n=10, and the experimental group was given 0.008% soybean isoflavone liquid ( 80 μg / mL), the control group was given the same volume of liquid matrix, and the volume of 50 μL per eye was locally administered to both eyes. On the 7th, 14th, and 21st day after the successful establishment of the mouse model, the choroidal vessels were measured by fluorescein angiography (FFA) and optical coherence tomography (OCT). The results of FFA combined with the results of OCT method were quantified and compared by t test. see results Figure 1 to Figure 4 .

[0034] Figure 1~3 The results showed that compared with the area of ​​vascular infiltration after 7 days of laser-induced mo...

Embodiment 2

[0037] Choroidal neovascularization (CNV) model induced by 532nm argon laser was selected from C57 / B6 mice. (The laser point should avoid the main blood vessels and be 2.5 to 3.0 optic disc diameters away from the optic nerve head.) The mice with successful modeling were divided into two groups, each group n=10, and the experimental group was given 0.012% soybean isoflavone liquid ( 120 μg / mL), the control group was given the same volume of liquid matrix, and the volume of 50 μL per eye was locally administered to both eyes. On the 7th, 14th, and 21st day after the successful establishment of the mouse model, the choroidal vessels were measured by fluorescein angiography (FFA) and optical coherence tomography (OCT). The results of FFA combined with the results of OCT method were quantified and compared by t test.

[0038] Compared with the area of ​​vascular infiltration area after 7 days of laser-induced model, the area of ​​vascular infiltration in the isoflavone treatment ...

Embodiment 3

[0040]Select healthy colored rabbits, male or female, weighing 2 to 3 kg, and use an argon green laser with a wavelength of 514.5 nm (spot diameter of 50 μm, power of 0.7 W, and time of 0.1 s) to place a spot on the lateral medulla 2 to 3 diameters away from the optic disc. Intensively irradiate 20 points above and below the retina. The rabbits with successful modeling were divided into two groups, with n=10 in each group. The experimental group was given 0.005% soybean isoflavone liquid (50 μg / mL), and the control group was given the same volume of liquid base, with a volume of 50 μL per eye. Administer to both eyes. On the 7th, 14th, and 21st day after the successful establishment of the mouse model, the choroidal vessels were measured by fluorescein angiography (FFA) and optical coherence tomography (OCT). The results of FFA combined with the results of OCT method were quantified and compared by t test. see results Figure 5 to Figure 7 .

[0041] Figure 5-7 The resul...

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Abstract

The invention firstly discloses an application of isoflavone in preparation of a drug for treating fundus maculopathy. The present invention finds for the first time that isoflavone can significantlyreduce the degree of fundus vascular permeability and has significant effect on fundus maculopathy. The invention not only provides the new use of isoflavone, but also provides the new drug for the treatment of fundus maculopathy, which has a good application prospect in the treatment of fundus maculopathy.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to the application of isoflavones in the preparation of medicines for treating fundus macular degeneration. Background technique [0002] The macular area is an important area of ​​the retina, located at the posterior pole of the eye, and is mainly related to visual functions such as fine vision and color vision. Once lesions appear in the macular area, vision loss, black shadows in front of the eyes or visual distortion often occur. Leakage of the microvessels responsible for supplying nutrition to the retina is the main cause of the disease, and even scars are formed. New abnormal blood vessels are also common. The fluid leaking from the blood vessels will damage the macula, causing visual distortion, vision loss, and excessive density. Scarring can lead to significant loss of central vision, affecting quality of life, and even blindness. [0003] In terms of...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P27/02A61P9/10
Inventor 吴绮峰曾凌霄
Owner GUANGDONG WHOLEWIN TECH
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