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A kind of Moringa oleifera leaf extract with cholate adsorption capacity and its preparation method and application

A technology of adsorption capacity and Moringa leaves, which is applied in the deep processing and high-value fields of Moringa leaves

Active Publication Date: 2021-11-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using Moringa oleifera leaves as raw materials, there are fewer reports on the development of extracts with cholate adsorption for lowering blood lipids

Method used

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  • A kind of Moringa oleifera leaf extract with cholate adsorption capacity and its preparation method and application
  • A kind of Moringa oleifera leaf extract with cholate adsorption capacity and its preparation method and application
  • A kind of Moringa oleifera leaf extract with cholate adsorption capacity and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A kind of Moringa oleifera leaf extract with cholate adsorption ability, specifically comprises the steps:

[0057] (1) Crushing and sieving: crush the dried Moringa leaves and pass through a 40-mesh sieve to obtain Moringa leaves dry powder 1 .

[0058] (2) Ethanol hot reflux to remove impurities: mix Moringa oleifera leaf dry powder 1 obtained in step (1) with absolute ethanol at a material-to-liquid ratio of 1:8g / mL, heat to 85°C for reflux extraction for 2 hours, remove the liquid, and precipitate at 45°C Dry for 4 hours to get Moringa leaf dry powder 2.

[0059] (3) Add water for homogenization: Moringa oleifera leaf dry powder 2 and deionized water are mixed with a material-to-liquid ratio of 1:10g / mL for homogeneous homogenization. During homogenization, the shear rate is 3000rpm, and the shear time is 10min. Suspension 1.

[0060] (4) Ultrasonic treatment: The suspension 1 obtained in step (3) was subjected to constant temperature ultrasonic treatment at 40° C...

Embodiment 2

[0070] A kind of Moringa oleifera leaf extract with cholate adsorption ability, specifically comprises the steps:

[0071] (1) Crushing and sieving: crush the dried Moringa leaves and pass through a 60-mesh sieve to obtain Moringa leaves dry powder 1 .

[0072] (2) Ethanol hot reflux to remove impurities: mix Moringa oleifera leaf dry powder 1 obtained in step (1) with absolute ethanol at a material-to-liquid ratio of 1:12g / mL, heat to 90°C for reflux extraction for 2.5h, remove the liquid, and precipitate for 55 Dry at ℃ for 5 hours to obtain dry powder of Moringa oleifera leaves 2.

[0073] (3) Add water for homogenization: Moringa oleifera leaf dry powder 2 is mixed with deionized water at a material-to-liquid ratio of 1:14g / mL, homogeneously homogenized, the shear rate during homogenization is 4000rpm, and the shear time is 15min to obtain a suspension Liquid 1.

[0074] (4) Ultrasonic treatment: The suspension 1 obtained in step (3) was subjected to constant temperature...

Embodiment 3

[0084] A kind of Moringa oleifera leaf extract with cholate adsorption ability, specifically comprises the steps:

[0085] (1) Crushing and sieving: crush the dried Moringa leaves and pass through an 80-mesh sieve to obtain Moringa leaves dry powder 1 .

[0086] (2) Ethanol hot reflux to remove impurities: mix Moringa oleifera leaf dry powder 1 obtained in step (1) with absolute ethanol at a material-to-liquid ratio of 1:16g / mL, heat to reflux at 95°C for 3 hours, remove the liquid, and precipitate at 65°C Dry for 6 h to get Moringa leaf dry powder 2.

[0087] (3) Add water for homogenization: Moringa oleifera leaf dry powder 2 is mixed with deionized water at a material-to-liquid ratio of 1:18g / mL, homogeneously homogenized, the shear rate during homogenization is 5000rpm, and the shear time is 20min to obtain a suspension Liquid 1.

[0088] (4) Ultrasonic treatment: The suspension 1 obtained in step (3) was ultrasonically treated at a constant temperature of 60° C. for 1.5...

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Abstract

The invention discloses a Moringa oleifera leaf extract with cholate adsorption capacity, a preparation method and application thereof. The preparation method adopts crushing and sieving, heat reflux of ethanol to remove impurities, adding water to homogenate, ultrasonic treatment, cellulase enzymatic hydrolysis, high temperature extraction, centrifugal separation, concentration under reduced pressure, fractional precipitation with ethanol, reconstitution with water, and second concentration under reduced pressure. , freeze-drying process to obtain a Moringa leaf extract with bile salt adsorption capacity. The total sugar content of the extract is more than 50%, and it has good bile salt adsorption capacity. The extraction process of the invention is simple, and the whole process flow can meet the requirements of food grade, and can be applied in the fields of medicine, health products and food.

Description

technical field [0001] The invention belongs to the field of deep processing and high value of moringa leaves, relates to a moringa leaf extract, in particular to a moringa oleifera leaf extract with cholate adsorption capacity and its preparation method and application. Background technique [0002] At present, with the improvement of living standards, the incidence of hyperlipidemia increases year by year. Hyperlipidemia, that is, hyperlipidemia, is a disease caused by excessive blood lipid levels in the body due to fat metabolism disorders, and can cause hyperglycemia and hypertension at the same time. The 2016 "Guidelines for the Prevention and Treatment of Dyslipidemia in Adults in China" shows that the current prevalence of dyslipidemia in adults in my country is 40.40%, which has increased significantly compared to 2002. Among them, the prevalence of hypercholesterolemia is 4.9%, and the prevalence of hypertriglyceridemia The prevalence of low high-density lipoprotein...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/06A23L33/105C08B37/00A61K127/00
CPCA61K36/185A23L33/105A61P3/06C08B37/00
Inventor 赵谋明杨延清林恋竹
Owner SOUTH CHINA UNIV OF TECH
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