Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof

A technology of laxative and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problems of affecting health, increasing side effects, and many drug components, so as to achieve good laxative effect Laxative, simple ingredients, and the effect of reducing the risk of side effects

Pending Publication Date: 2019-06-28
TSING HUA DE REN XIAN HAPPINESS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The lifestyle of modern people has undergone great changes compared with the past. Many people are sedentary, they are not tired of eating fine food, and their fiber intake is getting less and less. Some people drink too much alcohol, and various reasons lead to digestive disorders Constipation of the large intestine is the most common phenomenon, which brings unspeakable suffering to many people and affects the health of the body
[0004] At present, there are many traditional Chinese medicine compositions for laxatives and laxatives on the market, but usually there are many and complex ingredients in the medicine.

Method used

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  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof
  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof
  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof

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Effect test

preparation example Construction

[0028] According to a typical embodiment of the present invention, a preparation method of the above-mentioned traditional Chinese medicine composition is provided. The preparation method comprises the following steps: S1, taking aloe and Fructus aurantii with a mass ratio of 2-5:1-10 and placing them in an extraction tank for extraction with water, the steam pressure of the extraction is 0.25-0.35 MPa, and the temperature is 70-5 90°C, after the leaching is completed, the extract is obtained; S2, the extract is concentrated under reduced pressure, the vacuum degree of the reduced pressure concentration is -0.08~-0.06MPa, the vapor pressure is 0.25~0.35MPa, and the temperature is 60~70 °C, to obtain the clear cream; and S3, to prepare the clear cream as an active ingredient into a traditional Chinese medicine composition for moistening the intestines and laxatives; preferably, the extraction is carried out in two or more times; more preferably, the extraction includes: the firs...

Embodiment 1

[0033] 1. Effect of 1# sample on small intestine peristalsis in mice

[0034] 1. Principle

[0035] The model-making drug compound diphenoxylate was given by oral gavage to establish a mouse small intestinal motility inhibition model, and the ink propulsion rate of the small intestine was calculated within a certain period of time to judge the gastrointestinal motility function of the model mice.

[0036] 2. Samples and Instruments

[0037] 2.1 Samples and instruments

[0038] 2.1.1 1# sample: provided by Tsinghua Deren Xi’an Xingfu Pharmaceutical Co., Ltd. (aloe vera-Fructus aurantium was fed at a ratio of 5:7, added an appropriate amount of water to decoct and extract, concentrated to 500ml, called the original solution), each 1ml is equivalent to the total Crude drug amount 0.4152g.

[0039] Above-mentioned stoste preparation method is as follows:

[0040] Take aloe vera and Citrus aurantii and put them in a multi-functional extraction tank at the same time, add 6-10 ti...

Embodiment 2

[0122] Effects of Different Proportions of Traditional Chinese Medicine Compositions on Moistening and Laxative Effects

[0123] 1 principle: through mouse gastrointestinal peristalsis experiment, mouse defecation experiment result the beneficial effect of the ratio of traditional Chinese medicine composition (aloe vera and Fructus Aurantii) in the present invention.

[0124] 1.1 Gastrointestinal motility experiment in mice: Oral administration of compound diphenoxylate, a modeling drug, established a mouse small intestinal motility inhibition model, calculated the ink propulsion rate of the small intestine within a certain period of time, and judged the gastrointestinal motility function of the model mice.

[0125] 1.2 Defecation experiment in mice: The modeling drug compound diphenoxylate was given by oral gavage to establish a mouse model of constipation, and the time of the first black stool, the number of black stools and the number of black stools discharged in the mice w...

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Abstract

The invention discloses a traditional Chinese medicine composition for relaxing bowels and a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition are prepared from the extracts of medicinal raw materials, and the medicinal raw materials include aloe and angelica sinensis according to the mass ratio of (2-5) to (1-10). By applying the technical scheme of the invention, the traditional Chinese medicine composition for relaxing bowels is simple in composition, the effective ingredients are extracted from the aloe and fructus aurantii,possibly existing excessive reactions of the complicated ingredients are avoided, the risk of side effects generated after medicine taking is obviously reduced, and the traditional Chinese medicine composition has a good bowel relaxing effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for relaxing bowels and laxatives, a preparation method and application thereof. Background technique [0002] Constipation is a common clinical symptom, which mainly refers to decreased frequency of defecation, decreased amount of feces, dry feces, and laborious defecation. When two or more of the above symptoms are present at the same time, it can be diagnosed as symptomatic constipation. Usually, the main reason is the decrease in the frequency of defecation. Generally, one defecation every 2 to 3 days or longer (or <3 times per week) is constipation. [0003] The lifestyle of modern people has undergone great changes compared with the past. Many people are sedentary, they are not tired of eating in dietary tests, and they consume less and less fiber. Some people drink too much alcohol, and various reasons le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61P1/10
CPCA61P1/10A61K36/886A61K36/752A61K2236/00A61K2236/30A61K2300/00A61K2236/331A61K2236/37
Inventor 杜成强
Owner TSING HUA DE REN XIAN HAPPINESS PHARMA
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