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Absorbable implantable device

An implantable and device technology, applied in the field of medical devices, can solve the problems of accelerating the metal matrix and the inability to effectively control the early degradation speed of the degradable polyester layer.

Pending Publication Date: 2019-07-02
BIOTYX MEDICAL SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the early degradation rate of the degradable polyester layer cannot be effectively controlled, it will accelerate the early corrosion of the resorbable metal matrix, making it difficult to maintain structural integrity or provide sufficient mechanical properties within 1 to 6 months after implantation. Support or connect the lesion

Method used

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  • Absorbable implantable device
  • Absorbable implantable device

Examples

Experimental program
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Effect test

preparation example Construction

[0046] see figure 1 , a method for preparing an absorbable implantable device, comprising the steps of:

[0047] S110: Provide an absorbable metal matrix.

[0048] The shape and material of the absorbable metal matrix are the same as above, and will not be repeated here.

[0049] S120: Dissolving the degradable polyester and the polymer in the first solvent to obtain a mixed polymer coating liquid.

[0050] The polymer is selected from at least one of a degradable polymer and a non-degradable polymer, or is selected from at least one monomer forming the degradable polymer and at least one monomer forming the non-degradable polymer. At least one of the copolymers.

[0051] Preferably, the degradable polymer is selected from at least one of poly(racemic lactic acid), polypropylene carbonate, polycaprolactone, polyglycolic acid and polylactic acid-glycolic acid copolymer, and the non-degradable polymer is selected from polyphenylene At least one of ethylene, polymethyl methac...

Embodiment 1

[0087] Provide a pure iron luminal stent matrix with a thickness of 50 microns, mix and dissolve poly(racemic lactic acid) (PDLLA) and polylactic acid (PLLA) with a mass ratio of 2:3 in chloroform, and prepare a concentration of 4 mg / ml The mixed polymer coating liquid of PDLLA and 6mg / ml PLA is coated with the mixed polymer coating liquid on the outer surface of the pure iron luminal stent base by ultrasonic atomization spraying method, and after vacuum drying, it is applied on the pure iron tube A mixed polymer coating is formed on the outer surface of the luminal stent matrix, and then the pure iron luminal stent matrix formed with a mixed polymer coating on the outer surface is soaked in pharmaceutical grade ethyl acetate and treated at room temperature for 15 minutes to make the PDLLA in the polymer coating After dissolving, taking out and vacuum drying, a degradable polyester layer is formed on the surface of the pure iron luminal stent matrix to obtain the absorbable vas...

Embodiment 2

[0091] Provide an iron-based alloy luminal stent matrix with a thickness of 55 microns, mix and dissolve polylactic acid (PLA) and polypropylene carbonate (PPC) with a mass ratio of 4:2 in tetrahydrofuran, and prepare the concentrations to be 2mg / ml The mixed polymer coating solution of PLA and 4mg / ml PPC is coated on the outer surface of the pure iron luminal stent base by ultrasonic atomization spraying method, and after vacuum drying, it is applied on the pure iron tube A mixed polymer coating is formed on the outer surface of the luminal stent matrix, and then the pure iron luminal stent with the mixed polymer coating formed on the outer surface is soaked in dimethyl sulfoxide and treated at 40°C for 10 minutes to dissolve the PPC, and then taken out. After natural drying, a degradable polyester layer was formed on the surface of the pure iron luminal stent base to obtain the absorbable vascular stent of this embodiment. The ultrasonic atomization spraying equipment is Med...

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Abstract

The invention relates to an absorbable implantable device comprising an absorbable metal matrix and a degradable polyester layer at least partially covering the surface of the absorbable metal matrix.The contact angle of the degradable polyester layer is more than or equal to 150 degrees. The degradable polyester layer has superhydrophobicity, and can form a hydrophobic barrier in body fluid to isolate the absorbable metal matrix from the body fluid, so as to protect the absorbable metal matrix from slow corrosion or even non-corrosion at the early stage of implantation; moreover, due to thesuperhydrophobicity of the degradable polyester layer, degradation of the degradable polyester layer in the aqueous body fluid environment can be delayed, and delaying or avoiding of the formation ofa local acidic environment at the early stage of implantation is facilitated. Therefore, adequate mechanical support can be provided in the repair period of lesion sites after implantation; while after the repair of the lesion sites is completed, the local micro-acid environment is produced by the degradation of the degradable polyester itself, and the absorbable metal matrix is allowed to be rapidly corroded.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an absorbable implantable device. Background technique [0002] After the absorbable implantable device is implanted into the human body, it supports or connects the diseased part until the diseased part heals or returns to normal shape and function, and the absorbable implantable device gradually corrodes or degrades and is completely absorbed by the body. Depending on the application site, it is generally believed that the healing period of the lesion is 1 to 6 months. That is, absorbable implantable devices need to maintain structural integrity within 1 to 6 months after implantation and have sufficient mechanical properties to support or connect the lesion. However, after 1 to 6 months of implantation, the lesion is healed, and the absorbable implantable device should be corroded or degraded as soon as possible within a relatively short period of time. [0003] Absorbable imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14
CPCA61L31/022A61L31/10A61L31/148A61L31/14C08L67/04
Inventor 林振健胡军孙宏涛张德元
Owner BIOTYX MEDICAL SHENZHEN CO LTD
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