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Ultrasonic controlled release prostate dilatation drug-delivery balloon system and preparation method thereof

A balloon and drug-loading technology, applied in the field of medical devices, can solve problems such as inability to load drugs and drain urine, unsatisfactory use and treatment effects, single function of balloon catheters, etc., to achieve good urethral dilatation and inhibition of benign prostatic hyperplasia, Improve the efficiency and effect, and the effect of treating benign prostatic hyperplasia

Inactive Publication Date: 2019-07-02
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the function of the balloon catheter is single, and it cannot load medicine and drain urine, and the use and treatment effect are not ideal.

Method used

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  • Ultrasonic controlled release prostate dilatation drug-delivery balloon system and preparation method thereof
  • Ultrasonic controlled release prostate dilatation drug-delivery balloon system and preparation method thereof
  • Ultrasonic controlled release prostate dilatation drug-delivery balloon system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0022] 1. Surface modification of ordinary balloons

[0023] 1. Use a 10.0*20 model (10.0mm in diameter and 20mm in length) to design serrated protrusions in the ordinary balloon forming mold. The sawtooth width is 0.5mm and the length is 18mm to make the mold required for non-compliant drug-loaded expansion balloon forming. .

[0024] 2. Use nylon raw materials to make a non-planar balloon according to conventional procedures and weld it on the balloon catheter.

[0025] 3. Perform plasma immersion treatment on the balloon segment of the balloon catheter to promote the adhesion of the drug coating. The specific steps are: place the catheter in the plasma immersion ion implantation device, after vacuuming, pass nitrogen gas, the gas pressure is 0.05~50 Pa; the radio frequency discharge power is 200~1200W; the amplitude of the loaded pulse high voltage power supply is 1KV~100KV, and the frequency is 50 ~40000 Hz or AC power 10-20 MHz, duty cycle 3%~80%; heating at 50~200℃ for...

specific Embodiment 2

[0039] 1. Surface modification of ordinary balloons

[0040] 4. Use a 10.0*20 model (diameter 10.0mm and length 20mm) to design serrated protrusions in the ordinary balloon forming mold. The sawtooth width is 0.5mm and the length is 18mm to make the mold required for non-compliant drug-loaded expansion balloon forming. .

[0041] 5. Use nylon raw materials to make a non-planar balloon according to conventional procedures and weld it on the balloon catheter.

[0042] 6. Perform plasma immersion treatment on the balloon segment of the balloon catheter to promote the adhesion of the drug coating. The specific steps are: place the catheter in the plasma immersion ion implantation device, after vacuuming, pass nitrogen gas, the gas pressure is 0.05~50 Pa; the radio frequency discharge power is 200~1200W; the amplitude of the loaded pulse high voltage power supply is 1KV~100KV, and the frequency is 50 ~40000 Hz or AC power 10-20 MHz, duty cycle 3%~80%; heating at 50~200℃ for 0.1~5...

specific Embodiment 3

[0056] 1. Surface modification of ordinary balloons

[0057] 7. Use a 10.0*20 model (10.0mm in diameter and 20mm in length) to design serrated protrusions in the ordinary balloon forming mold. The sawtooth width is 0.5mm and the length is 18mm to make the mold required for non-compliant drug-loaded dilation balloon forming. .

[0058] 8. Use nylon raw materials to make a non-planar balloon according to conventional procedures and weld it on the balloon catheter.

[0059] 9. Perform plasma immersion treatment on the balloon segment of the balloon catheter to promote the adhesion of the drug coating. The specific steps are: place the catheter in the plasma immersion ion implantation device, after vacuuming, pass nitrogen gas, the gas pressure is 0.05~50 Pa; the radio frequency discharge power is 200~1200W; the amplitude of the loaded pulse high voltage power supply is 1KV~100KV, and the frequency is 50 ~40000 Hz or AC power 10-20 MHz, duty cycle 3%~80%; heating at 50~200℃ for ...

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Abstract

The invention relates to an ultrasonic controlled release prostate dilatation drug-delivery balloon system. The system comprises a balloon catheter, a dilatation balloon and an ultrasound probe. The dilatation balloon catheter has a four-chamber structure, and three chambers are used for balloon filling and the other chamber for drainage of urine. The compliant balloons at both ends are located atthe lower end of the bladder and urethra to secure the dilatation balloon system and reduce damage from displacement and friction. The drug-loaded balloon is used for dilatation of the narrow urethra, and the surface is designed with a spiral shape, a zigzag shape, a wave shape, and the like, and a specific surface area is increased to increase the drug loading. Drug loading can be realized through the microcapsules with different particle sizes, microcapsules can be stimulated by ultrasound with a certain intensity and frequency to release into the urethra mucosa and prostate to treat urethral stricture caused by prostatic hyperplasia. The small ultrasound probe can be used in vitro or in the rectum. The real-time contrast during the catheterization process accurately identifies the urethral stricture, so that the dilatation process is more intuitive and accurate. The ultrasonic probe can also control the intensity, frequency and time of the ultrasonic wave in real time, so that thedrug-loaded microcapsules on the surface of the dilatation drug-delivery balloon can be released at the target position, and the drug utilization rate and therapeutic effect are obtained.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a targeted dilation balloon system, in particular to a drug-loaded urethral dilation balloon system with non-compliance metal double-cavity drainage and inserted through a urethroscope. This kind of balloon system can be applied to the treatment of urethral stricture caused by benign prostatic hyperplasia and other reasons. It can not only expand the urethra to drain urine, but also treat the cause and prevent restenosis, so as to improve the quality of life of patients. Background technique [0002] With the improvement of living standards, the prolongation of personal life and the aggravation of aging, more and more elderly people are suffering from geriatric diseases. Among them, benign prostatic hyperplasia is a common disease in elderly men. The incidence rate of adult males in the United States is as high as 33.7%, and the incidence rate of males in my country is 16%, and there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M29/02A61B8/12
CPCA61M29/02A61B8/12
Inventor 张海军徐忠华田振凡侯文博周超尹玉霞鲁手涛刘光
Owner SHANDONG BRANDEN MEDICAL DEVICE
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