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Application of defatted cinnamon polyphenol extract in the preparation of products for the prevention and treatment of diabetic nephropathy

A technology for diabetic nephropathy and extracts, applied in the field of medicinal natural products, can solve the problems of single use of cinnamon polyphenols and large differences, and achieve the effects of full utilization, low cost of raw materials, and simple and easy extraction methods.

Active Publication Date: 2021-09-21
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cinnamon is used for extraction, Document 2 and Document 3, and Patent 4 respectively use methyl chardone, cinnamon oil, cinnamic acid / aldehyde, all of which are fat-soluble components of cinnamon, but the present invention uses defatted cinnamon for extraction. Extraction, so the obtained extract is very different from Document 2, Document 3, and Patent 4
At present, there is no report on the use of cinnamon polyphenols with relatively high purity and clear main components for the preparation of foods and medicines for the auxiliary treatment of diabetic nephropathy.

Method used

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  • Application of defatted cinnamon polyphenol extract in the preparation of products for the prevention and treatment of diabetic nephropathy
  • Application of defatted cinnamon polyphenol extract in the preparation of products for the prevention and treatment of diabetic nephropathy
  • Application of defatted cinnamon polyphenol extract in the preparation of products for the prevention and treatment of diabetic nephropathy

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Experimental program
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Effect test

Embodiment 1

[0029] Application of defatted cinnamon polyphenol extract in the preparation of products for the prevention and treatment of diabetic nephropathy, wherein the defatted cinnamon polyphenol extract includes cinnamon tannin and cinnamon epicatechin or a mixture of both, cinnamon tannin and cinnamon epicatechin The structural formula of cinnamon epicatechin is as follows:

[0030]

[0031] The mixture of cinnamon tannin and cinnamon epicatechin is mixed in any proportion.

[0032] A method for extracting a defatted cinnamon polyphenol extract is specifically divided into two steps, namely, the first step is supercritical degreasing to obtain the defatted cinnamon, and the second step is solvent extraction of the cinnamon polyphenol extract. The first step of supercritical degreasing to obtain degreasing cinnamon is as follows: take cinnamon bark and grind it, put it into supercritical CO 2 In the extraction kettle, the extraction pressure is 25~45MPa, the extraction temperatu...

Embodiment 2

[0034] A method for extracting a defatted cinnamon polyphenol extract is specifically divided into two steps, namely, the first step is supercritical degreasing to obtain the defatted cinnamon, and the second step is solvent extraction of the cinnamon polyphenol extract. The first step of supercritical degreasing to obtain degreasing cinnamon is as follows: take cinnamon bark and grind it, put it into supercritical CO 2 In the extraction kettle, extraction pressure is 25MPa, extraction temperature is 30°C~75°C, separation I pressure is 10MPa, separation I temperature is 25°C~75°C, separation II pressure is 4MPa, separation II temperature is 25°C~55°C, CO 2 The flow rate is 10kg per kilogram of raw material per hour, the extraction is 10h, and the defatted cinnamon is taken out from the extract. The specific steps of the second step of solvent extraction of cinnamon polyphenols extract are as follows: add 75% ethanol at a ratio of 1 to 9 times the weight of defatted cinnamon un...

Embodiment 3

[0036] A method for extracting a defatted cinnamon polyphenol extract is specifically divided into two steps, namely, the first step is supercritical degreasing to obtain the defatted cinnamon, and the second step is solvent extraction of the cinnamon polyphenol extract. The first step of supercritical degreasing to obtain degreasing cinnamon is as follows: take cinnamon bark and grind it, put it into supercritical CO 2 In the extraction kettle, extraction pressure is 35MPa, extraction temperature is 30°C~75°C, separation I pressure is 20MPa, separation I temperature is 25°C~75°C, separation II pressure is 6MPa, separation II temperature is 25°C~55°C, CO 2 The flow rate is 20kg per kilogram of raw material per hour, the extraction is 8h, and the defatted cinnamon is taken out from the extract. The specific steps of the second step of solvent extraction of cinnamon polyphenols extract are as follows: Add 60% ethanol with a volume fraction of 6 times the weight of degreased cinn...

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Abstract

The invention belongs to the technical field of medicinal natural products, and in particular relates to the application of a defatted cinnamon polyphenol extract extracted from cinnamon bark in the preparation of products for preventing and treating diabetic nephropathy. The weight content of total polyphenols in the defatted cinnamon polyphenol extract is 40% to 80%, and the main active ingredients in the total polyphenols are cinnamon tannin and cinnamon epicatechin or a mixture of both; The active ingredients can reduce urinary albumin and kidney index in rats with diabetic nephropathy, reduce glycated serum albumin, glycosylated hemoglobin, blood creatinine and blood urea nitrogen in rats with diabetic nephropathy; the defatted cinnamon polyphenol extract provided by the present invention can relieve severe diabetic nephropathy The kidney injury of rats has the effect of preventing diabetic nephropathy, and is expected to be used in the treatment of diabetic nephropathy and other diseases.

Description

technical field [0001] The invention belongs to the technical field of medicinal natural products, and in particular relates to the application of a defatted cinnamon polyphenol extract extracted from cinnamon bark in the preparation of products for preventing and treating diabetic nephropathy. Uses in food and medicine related to kidney injury and prevention of diabetic nephropathy. Background technique [0002] In 2013, the incidence of diabetes in my country reached 10.9%, ranking first in the world with 110 million diabetic patients. Diabetic nephropathy is one of the most common serious complications of diabetes, and it is also the leading cause of end-stage renal failure. Its treatment mainly adopts comprehensive measures of controlling blood sugar, blood lipids and appropriate use of diuretics, but these treatment measures have limited efficacy and there is no targeted treatment Drugs for diabetic nephropathy emerge. The pathogenesis of diabetic nephropathy is very ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/353A61P3/10A61P13/12A23L33/105
CPCA23V2002/00A61K31/352A61K31/353A23L33/105A61P3/10A61P13/12A23V2200/328A23V2200/30A23V2250/2132
Inventor 李宇清夏星刘思彤霍丽妮尹日凤钟静梁明坤韦建华丘芬
Owner GUANGXI UNIV OF CHINESE MEDICINE