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Application of cyclic dipeptides in preparing medicines for chronic atrophic gastritis

A technology of atrophic gastritis and cyclic dipeptide, which is applied in the field of biopharmaceuticals and achieves excellent therapeutic effects

Inactive Publication Date: 2019-07-05
INNER MONGOLIA JINGXIN PHARMACEUTICAL CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature disclosing the effect of a specific ingredient contained in Periplaneta americana on the treatment of digestive tract diseases

Method used

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  • Application of cyclic dipeptides in preparing medicines for chronic atrophic gastritis
  • Application of cyclic dipeptides in preparing medicines for chronic atrophic gastritis
  • Application of cyclic dipeptides in preparing medicines for chronic atrophic gastritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 The preparation embodiment of six kinds of cyclic dipeptides of the present invention

[0046] 1) Take 400ml (about 218 grams) of the ethanol extract of Periplaneta americana and spin dry the ethanol, dissolve it in deionized water and concentrate it under reduced pressure to a suitable concentration, and then put it directly on the HP-20 macroporous resin column with a column volume of 3.2L without filtration Chromatography, eluting with water, concentrating the eluate under reduced pressure and freeze-drying to obtain the water fraction (156 g).

[0047] 2) 35 g of the water-eluted part of Periplaneta americana obtained above is eluted with water through MCI column chromatography (filler is Mitsubishi Chemical MCI GEL CHP20P) with a column volume of 380 ml, and water fraction A is obtained in each Erlenmeyer flask (32g). Each bottle of component A is detected with TLC, developing agent is n-butanol: glacial acetic acid: water=4:1:1, ninhydrin develops co...

Embodiment 2

[0063] Embodiment 2 The effect embodiment of six kinds of cyclic dipeptides of the present invention

[0064]1. Experimental materials

[0065] 1.1 Samples: Six kinds of cyclic dipeptides in Example 1: cyclopro-silk dipeptide, cyclopro-asparagine dipeptide, cyclopro-leutopeptide, cyclopro-isoleucide, cyclopro-propan dipeptide, cyclopro pro-val dipeptide

[0066] 1.2 Experimental animals: 90 SD rats, body weight: 140-160g, SPF grade, source: Shanghai Schiphol-Bikay Experimental Animal Co., Ltd.

[0067] Mongolian gerbils: 90 gerbils, weighing 75±5g, SPF grade, source: Shanghai Schiphol-Bikay Experimental Animal Co., Ltd.

[0068] 1.3 Test reagents: Helicobacter pylori (Hp) international standard strain ATCC43504 (provided by Renji Hospital Affiliated to Shanghai Jiaotong University); Hp inoculation kit and inoculation loop (Shanghai Pusheng Biotechnology Co., Ltd.); sodium deoxycholate (Shanghai Pusheng Biotechnology Co., Ltd.); folic acid tablets (Tianjin Lisheng Pharmaceut...

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Abstract

The present invention relates to an application of any one of cyclic Pro-Ser dipeptides, cyclic Pro-Asn dipeptides, cyclic Pro-Leu dipeptides, cyclic Pro-Ile dipeptides, cyclic Pro-Ala dipeptides, andcyclic Pro-Val dipeptides in preparing medicines for chronic atrophic gastritis. Therapeutic effects after a chronic atrophic gastritis modeling experiment prove that the above six cyclic dipeptidesare excellent in the therapeutic effects on the chronic atrophic gastritis.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to the application of cyclic dipeptide in medicine for treating chronic atrophic gastritis. Background technique [0002] Cyclic dipeptide, also known as 2,5-dioxopiperazine, is formed by the cyclization of two amino acids through a peptide bond, and is the smallest cyclic peptide in nature. Many cyclic dipeptides are naturally present in plants and animals, and some are formed through fermentation or during food processing. Current research on the biological activity of cyclic dipeptides includes antibacterial, anticancer, effects on the cardiovascular system, neuron protection and brain function improvement, addiction and detoxification. For example, it has been reported in the literature that cyclic (pro-silk) dipeptide has antibacterial effects, especially on Staphylococcus aureus; cyclic (leu-pro) dipeptide has inhibitory effects on breast cancer, cervical cancer and colon ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985A61P1/04C07D487/04
CPCA61K31/4985C07D487/04
Inventor 成亮袁建业崔晓旭郭夫江刘力林琳
Owner INNER MONGOLIA JINGXIN PHARMACEUTICAL CO LTD
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