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Xiao-xu-ming decoction component formula for treating cardiovascular and cerebrovascular spasm, stenocardia and cerebral infarction

A small Xuming decoction, cardiovascular and cerebrovascular technology, applied in the field of medicine, can solve the problems of insignificant effect, large toxic and side effects, etc., achieve the goal of relieving coronary heart disease, angina pectoris and cerebrovascular disease, low toxic and side effects, and significant synergistic effect Effect

Inactive Publication Date: 2019-07-12
HEBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing drugs for the treatment of coronary heart disease angina pectoris have relatively large toxic and side effects, and the effect is not obvious.

Method used

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  • Xiao-xu-ming decoction component formula for treating cardiovascular and cerebrovascular spasm, stenocardia and cerebral infarction
  • Xiao-xu-ming decoction component formula for treating cardiovascular and cerebrovascular spasm, stenocardia and cerebral infarction
  • Xiao-xu-ming decoction component formula for treating cardiovascular and cerebrovascular spasm, stenocardia and cerebral infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Xiao Xuming Decoction Component Formula Capsule

[0025] Make capsules according to the following ratio (10000 capsules, the contents of the first class drug components ephedrine hydrochloride, cinnamon aldehyde, amygdalin, glycyrrhizic acid, ginsenoside Rg1, paeoniflorin, ferulic acid, baicalin, and tetrandrine are respectively : 50mg / capsule, the contents of the second class of drug components acteoside, aconitine and 6-gingerol are 75mg / capsule respectively)

Embodiment 2

[0026] Embodiment 2 small Xuming decoction component formula tablet

[0027] Tablets are made according to the following ratio (10000 tablets, the contents of the first class drug components ephedrine hydrochloride, cinnamon aldehyde, amygdalin, glycyrrhizic acid, ginsenoside Rg1, paeoniflorin, ferulic acid, baicalin, and tetrandrine respectively For: 80mg / capsule, the contents of the second class of drug components acteoside, aconitine and 6-gingerol are respectively: 120mg / capsule)

Embodiment 3

[0028] Example 3 Effect of Xiaoxuming Decoction Component Formula Different Dosage Groups on Amino Acid Neurotransmitter Contents in Striatum of Cerebral Ischemia Rats

[0029] The right middle cerebral artery occlusion (middle cerebral artery occlusion, MCAO) was prepared by suture method to establish the rat model of focal cerebral ischemia, and the amino acid neurons in the striatum of cerebral ischemia rats were observed by microdialysis (MD) technique. The content changes of transmitters (Glu, Asp, Gly, γ-GABA) and the intervention of different dosage groups of Xiaoxuming Decoction component formulas were analyzed to regulate amino acid neurotransmitters in the brain with different doses of Xiaoxuming Decoction component formulas, and the brain Protective effect on neuronal damage in brain tissue after ischemia.

[0030] 3.1 Experimental grouping Rats were randomly divided into 6 groups (n=10): ① normal group (Control group); ② sham operation group (Sham operation group):...

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Abstract

The invention relates to the field of medicine, in particular to a Xiao-xu-ming decoction component formula for treating cardiovascular and cerebrovascular spasm, stenocardia and cerebral infarction.The Xiao-xu-ming decoction comprises 10-20 parts of ephedrine hydrochloride, 10-20 parts of cinnamaldehyde, 10-20 parts of amygdalin, 10-20 parts of glycyrrhizic acid, 10-20 parts of ginsenoside, 10-20 parts of paeoniflorin, 10-20 parts of ferulic acid, 10-20 parts of baicalin, 10-20 parts of tetrandrine, 10-30 parts of prim-O-glucosylcimifugin, 10-30 parts of aconitine, and 10-30 parts of 6-gingerol. The Xiao-xu-ming decoction can significantly alleviate coronary heart disease angina and cerebrovascular disease, and the effect is better than that of the same dose of the first class of drugs including ephedrine hydrochloride, cinnamaldehyde, amygdalin, glycyrrhizic acid, ginsenoside Rg1, paeoniflorin, ferulic acid, baicalin and tetrandrine, or the same dose of the second class of drugs including prim-O-glucosylcimifugin, aconitine and 6-gingerol; a significant synergistic effect is achieved, the toxic and side effect is small, and the clinical application prospects are good.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the component formula of Xiao Xu Ming Decoction for treating cardiovascular and cerebrovascular spasm, angina pectoris and cerebral infarction. Background technique [0002] Coronary heart disease and angina pectoris belong to the categories of "chest pain", "heart pain", "deep heart pain", "jue heart pain" and "true heart pain" in traditional Chinese medicine. Cerebrovascular diseases include two major types: ischemic and hemorrhagic, and belong to the syndromes of "stroke", "big Jue", "thin Jue", "pushing", "partial dryness" and "wind prickly heat". , hemiplegia, crooked tongue, slurred or silent speech, and numbness in one side of the body are the main clinical manifestations of the disease. However, the existing medicines for treating angina pectoris of coronary heart disease have relatively large toxic and side effects, and the effect is not obvious. Contents of the invention [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/11A61K31/122A61K31/137A61K31/192A61K31/439A61K31/4748A61K31/7028A61K31/704A61P9/10
CPCA61K31/7028A61K31/4748A61K31/137A61K31/11A61K31/704A61K31/7048A61K31/192A61K31/439A61K31/122A61P9/10A61K2300/00
Inventor 武密山武博文
Owner HEBEI UNIV OF CHINESE MEDICINE
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