Synthesis method of nicotinamide modified polyaspartic acid derivative

A technology of polyaspartic acid and synthesis method, which is applied in the field of graft-modified polyaspartic acid derivative synthesis, can solve the problems of no polyaspartic acid derivative reports, etc., and achieve good hydrophilicity, The effect of improving skin texture

Inactive Publication Date: 2019-07-19
苏州美瑞姿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the field of cosmetic applications, there is no report on related polyaspartic acid derivatives

Method used

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  • Synthesis method of nicotinamide modified polyaspartic acid derivative

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preparation example Construction

[0015] A kind of synthetic method of the polyaspartic acid derivative of nicotinamide modification of the present invention, it comprises the following steps:

[0016] Step 1. Synthesis of polysuccinimide: add 100-150 parts of L-aspartic acid and 2-6 parts of phosphoric acid catalyst to the kneading reactor respectively, heat up and dehydrate and condense under vacuum conditions to obtain intermediate polysuccinimide Body (PSI);

[0017] Step 2, adding nicotinamide to the kneading reactor in step 1, maintaining the reaction conditions in step 1, and continuing the reaction to obtain a polysuccinimide derivative grafted with nicotinamide;

[0018] Step 3. Add the nicotinamide-modified polysuccinimide derivatives prepared in step 2 into the hydrolysis tank, add water 3-6 times the weight of the polysuccinimide derivatives, stir and disperse, and heat and maintain stirring Slowly add NaOH solution dropwise under the conditions for hydrolysis, and the hydrolyzed product is polyas...

Embodiment 1

[0025] Example 1: Add 100 parts of L-aspartic acid and 6 parts of phosphoric acid catalyst into the kneading reactor, dehydration condensation at 170°C and -70kPa for 2 hours to obtain polysuccinimide intermediate (PSI). Next, 20 parts of nicotinamide was added into the reactor, and the above reaction conditions were maintained to continue the reaction for 2 hours to obtain a nicotinamide-modified polysuccinimide derivative. Add the polysuccinimide derivative modified by nicotinamide into the hydrolysis tank, add water to stir and disperse, slowly add 3mol / L NaOH solution dropwise at 40°C and keep stirring for 2.5h to obtain nicotinamide graft modified polyaspartic acid saline solution. The aqueous solution is purified and further refined through steps such as pH adjustment, filtration, ultrafiltration, and concentration. The obtained nicotinamide-modified polyaspartic acid had a molecular weight of 15,000 and a grafting rate of 14%.

Embodiment 2

[0026] Example 2: Add 100 parts of L-aspartic acid and 3 parts of phosphoric acid catalyst into the kneading reactor, dehydration condensation at 185°C and -50kPa for 3 hours to obtain polysuccinimide intermediate (PSI). Next, 40 parts of nicotinamide was added into the reactor, and the above reaction conditions were maintained to continue the reaction for 1 hour to obtain a nicotinamide-modified polysuccinimide derivative. Add the polysuccinimide derivative modified by nicotinamide into the hydrolysis tank, add water to stir and disperse, slowly add 4 mol / L NaOH solution dropwise under the condition of maintaining stirring at 50°C for 5 hours, and obtain the nicotinamide graft-modified polysuccinimide derivative. Polyaspartic Acid Saline Solution. The aqueous solution is purified and further refined through steps such as pH adjustment, filtration, ultrafiltration, and concentration. The prepared nicotinamide-modified polyaspartic acid had a molecular weight of 18000 and a gr...

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Abstract

The invention relates to a synthesis method of a nicotinamide modified polyaspartic acid derivative. The nicotinamide modified polyaspartic acid derivative is synthesized by using L-aspartic acid as araw material, phosphoric acid as a catalyst, and nicotinamide as a modifier. The synthesis method mainly comprises the following steps: stirring L-aspartic acid and phosphoric acid, heating to obtainpolysuccinimide (PSI), adding nicotinamide into a PSI reaction kettle, reacting to enable PSI to be subjected to ring-opening grafting to achieve the purpose of modification, and finally adding an alkali solution for hydrolysis to obtain a nicotinamide grafted and modified polyaspartic acid derivative sodium salt aqueous solution. The synthesis method disclosed by the invention is simple and easyto operate, and the grafting modification step and the polymerization step are coupled in one reactor, so that the process steps can be simplified, and the polymerization degree and the grafting ratecan be regulated and controlled. The synthesized nicotinamide modified polyaspartic acid derivative has good hydrophilicity, fat solubility and chelation, has the effects of moisturizing, removing freckles, whitening, improving skin quality, removing heavy metals and the like, and is a multifunctional and high-value polyaspartic acid derivative product.

Description

technical field [0001] The invention relates to a method for synthesizing graft-modified polyaspartic acid derivatives, in particular to a method for synthesizing polyaspartic acid derivatives using nicotinamide as a modifier. Background technique [0002] Polyaspartic acid (PASP) is a high molecular polymer formed by polycondensation of L-aspartic acid. Polyaspartic acid is essentially a polypeptide, which is safe and harmless to the biological environment. Moreover, the main chain of polyaspartic acid has a large number of carboxyl groups, so it has the function of chelating metal ions, and can be widely used in fields such as agriculture, industry, and medicine as fertilizer slow-release agents, scale inhibitors, and drug carriers. Polyaspartic acid has good hydrophilicity, film-forming properties, chelating properties and safety, and has potential application value in the field of daily chemical skin care products, and has very good commercial prospects. Unfortunately,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/10
CPCC08G73/1092
Inventor 吴有庭陈雷庄薇娜
Owner 苏州美瑞姿生物科技有限公司
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