Zinc chloride hydroxide having excellent zinc ion sustained-releasability and production method therefor

A hydroxide and manufacturing method technology, applied in the direction of zinc oxide/zinc hydroxide, zinc halide, medical preparations containing active ingredients, etc., can solve the problems of unstudied drug ingredients, etc., and achieve the effect of excellent stability

Inactive Publication Date: 2019-07-19
KAWATETABU MINING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the use of basic zinc chloride such as Simonkolleite as a pharmaceutical ingredient in pharmaceuticals has not been studied.

Method used

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  • Zinc chloride hydroxide having excellent zinc ion sustained-releasability and production method therefor
  • Zinc chloride hydroxide having excellent zinc ion sustained-releasability and production method therefor
  • Zinc chloride hydroxide having excellent zinc ion sustained-releasability and production method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0104] Hereinafter, although an Example demonstrates this invention concretely, this invention is not limited to an Example.

preparation example 1

[0106] 500 mL of a 0.08 M ammonium chloride aqueous solution was prepared in a reaction vessel, and 1000 mL of a 0.1 M zinc chloride aqueous solution was separately prepared as a dropwise reaction solution. A 30% by mass sodium hydroxide aqueous solution was prepared as a pH adjusting solution.

[0107] Using a pH controller connected to a pump, an aqueous zinc chloride solution and an aqueous sodium hydroxide solution were added dropwise while stirring while maintaining the pH of the above-mentioned ammonium chloride solution at 6.5. After all the zinc chloride aqueous solution was added dropwise, it was stirred for 16 hours and aged.

[0108]Thereafter, the reaction liquid was subjected to solid-liquid separation by centrifugation, and washing with water and centrifugation were repeated three times for the obtained solid. The precipitate washed in this way was vacuum-dried to obtain a dried zinzinite powder having a composition range represented by the formula (1).

preparation example 2

[0110] The pH at the time of synthesis was set at 5.5 to 10, and each sample obtained by changing the pH at the time of production including Production Example 1 (pH 6.5) was produced by the same process as Formulation Example 1. At pH 5.5, no precipitate was obtained because the pH was too low.

[0111] (dissolution test)

[0112] 0.6 g of each dry powder obtained in Formulation Example 2 was subjected to a dissolution test based on a stirring method using 30 g of physiological saline, and Zn 2+ Determination of ion dissolution and pH. For the dissolution test method, adjust the BET specific surface area of ​​zinc chloride hydroxide hydrate containing chlorohydrinite to 10 to 150 m 2 / g, the mass ratio of zinc chloride hydroxide hydrate containing chlorohydrinite to normal saline is 1:50, the stirring time is 3 hours at 500 rpm using the rotor, and the pH and Zn after the dissolution test are measured 2+ Ion dissolution. show the result in Figure 7 , Figure 8 and Tabl...

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Abstract

Provided are: zinc chloride hydroxide that is useful as a pharmaceutical ingredient, has excellent zinc ion sustained-releasability when used as a pharmaceutical agent, and exhibits excellent stability as a pharmaceutical ingredient; and a production method therefor. The present invention pertains to zinc chloride hydroxide that can be used as a pharmaceutical ingredient, that has excellent zinc ion sustained-releasability, that comprises at least one member selected from the group consisting of zinc chloride, zinc hydroxide, and zinc oxide, and that, after an elution test is performed on a zinc chloride hydroxide hydrate containing simonkolleite by an agitation method, shows a Zn2+ ion elution per surface area of 0.25-100 [mu]g / m2 and a pH of not lower than 7.0 but lower than 8.3.

Description

technical field [0001] The present invention relates to a zinc chloride hydroxide having excellent zinc ion sustained release properties and a method for producing the same, which can be used as a pharmaceutical ingredient of pharmaceuticals. Background technique [0002] In paragraph [0013] of Patent Document 1, it is described that "it was found that administering a relatively large amount of high-absorbable zinc before the administration of botulinum toxin therapy can reduce the toxin resistance of people who previously lacked response. Responsiveness becomes effective, and, in addition, significantly increases the functional efficacy of botulinum toxin in others as well.” As an illustration of such a "zinc supplement", paragraph [0045] of Patent Document 1 describes inorganic zinc or organic zinc or a combination thereof for oral administration, zinc chloride (ZnCl 2 ), basic zinc chloride (Zn 5 Cl 2 (OH) 8 ), zinc oxide (ZnO), zinc sulfate (ZnSO 4 ). [0003] Howe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61L15/18A61P17/02
CPCA61K33/30A61L15/18A61P17/02A61K45/06A61K9/0014A61L15/44A61L26/0004A61L26/0066C01G9/02A61L2300/102A61L2300/412A61L2430/34C01P2002/74C01G9/04
Inventor 中田圭美越前谷木绵子宇田川悦郎山本修
Owner KAWATETABU MINING
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