Purpose of chlorophyll derivative for improving muscle microcirculation disorder

A technology of microcirculation disorder and chlorophyll, which is applied in the field of medicine, can solve the problems of easily causing stomach discomfort, limited users, high drug prices, etc., to prevent and improve muscle microcirculation disorders, and is applicable to a wide range of people. safe effect

Active Publication Date: 2019-08-06
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the existing drugs not only have obvious toxic and side effects, but are likely to cause adverse reactions and side effects such as stomach discomfort, nausea, heartburn, loss of appetite, skin r...

Method used

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  • Purpose of chlorophyll derivative for improving muscle microcirculation disorder
  • Purpose of chlorophyll derivative for improving muscle microcirculation disorder
  • Purpose of chlorophyll derivative for improving muscle microcirculation disorder

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] Preparation of reference solution: Accurately weigh 0.143g of spectrally pure ferric oxide dried at 130°C to constant weight, put it in a beaker, add 5ml of hydrochloric acid solution (1→2) to dissolve, transfer to a 100ml measuring bottle, add Add 4ml of hydrochloric acid solution (1→2), add water to the mark, shake well, accurately measure 10ml, put it in a 100ml measuring bottle, add water to the mark, shake well to get a solution containing about 100μg of Fe per 1ml. Accurately measure 0, 0.2, 0.4, 0.6, 0.8 and 1.0ml of the above solutions respectively, put them in a 10ml measuring bottle, add nitric acid solution (1→500) to the mark, shake well, and you get it.

[0052] Preparation of the test solution: Take an appropriate amount of sample, grind it finely, accurately weigh 10mg, put it in a 50ml beaker, add 1.5ml of nitric acid, 3 drops of perchloric acid, cover with a watch glass, heat to nearly dry at 150-160°C, add Nitric acid (1→2) 2ml, cover with a watch glas...

Embodiment 1

[0086] Example 1 The protective effect of silkworm excrement extract on muscle acute microcirculation disturbance

[0087] According to the above-mentioned method, the iron chlorophyllin sodium weight percentage content is about 37.6%, and other chlorophyll derivatives are calculated as iron chlorophyllin (b) for more than 60.0% of the silkworm excrement, for its effect on rabbit muscle acute microcirculation disorder The role of the test, the results are as follows.

[0088] Table 1 The effect of silkworm excrement extract on the change rate of rabbit muscle microcirculation ( n=6)

[0089]

[0090] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0091] Table 1 shows that, compared with the negative control group, the change rate of blood perfusion (PU) in the high and middle dose groups of silkworm excrement extract was significantly reduced (P<0.01); The rate of change was significantly reduced (P<0.01). The change rate of blood cell velocity...

Embodiment 2

[0092] Example 2 The protective effect of silkworm excrement extract on acute microcirculation disturbance

[0093] The experiment of Example 1 was repeated, except that the iron chlorophyllin sodium sodium iron chlorophyllate content was about 29.1% by weight, and other chlorophyll derivatives were tested with iron chlorophyllin (b) as the silkworm excrement above 60.0%. The results showed that blood perfusion (PU), blood cell aggregation (CMBC) and movement blood cell velocity (V) rate of change in the high, middle and low dose groups all decreased, indicating that the muscle microcirculation disturbance of the tested rabbits was improved.

[0094] It can be known from the above examples that sodium ferric chlorophyllin and chlorophyll derivatives containing sodium ferric chlorophyllin (such as silkworm excrement) can effectively improve or regulate blood perfusion, concentration of moving blood cells and speed of moving blood cells, thereby improving muscle Acute microcircula...

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Abstract

The present invention belongs to the field of a medicine and relates to the use of a chlorophyll derivative for improving muscle microcirculation disorder, in particular the use of the chlorophyll derivative for preparation of a medicine for treatment and/or prevention of muscle microcirculation disorder. The chlorophyll derivative of the present invention, such as a chlorophyll extract and a silkworm extract, has the good effect on improving muscle microcirculation disorder. The chlorophyll derivative can also comprehensively prevent and improve the muscle microcirculatory disorder by actingin a plurality of links. Moreover, the toxic and side effects of the chlorophyll derivative are improved, the chlorophyll derivative is suitable for a wide range of people and is safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, a preparation method of the chlorophyll derivative and the method for preparing the medicine are relatively simple,and the cost is effectively controlled.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving muscle microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing muscle microcirculation disorders. Background technique [0002] Microcirculation refers to the blood circulation in capillaries between arterioles and venules. It is the part of the cardiovascular system in direct contact with tissue cells. The basic function of microcirculation is to carry out metabolism and material exchange. It is an important part of blood circulation and can be called the "second heart" of the human body. During the evolution process, organ microvessels and their parenchymal cells form a closely coordinated and highly adaptive three-dimensional structure. For the convenience of research, the configuration of organ microvessels is usually classified into hairpin type, dendrite typ...

Claims

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Application Information

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IPC IPC(8): A61K31/555A61P7/00
CPCA61K31/555
Inventor 刘朝胜刘敏付雯吴瑜罗京余明森王根才周红晖袁建新徐发新
Owner 武汉联合药业有限责任公司
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