Use of chlorophyll derivatives to improve muscle microcirculation disorder

A technology of microcirculation disorder and chlorophyll, which is applied in the field of medicine, can solve problems such as easy stomach discomfort, high drug prices, and limited use of people, so as to prevent and improve muscle microcirculation disorders, and is applicable to a wide range of people. safe effect

Active Publication Date: 2021-12-24
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the existing drugs not only have obvious toxic and side effects, but are likely to cause adverse reactions and side effects such as stomach discomfort, nausea, heartburn, loss of appetite, skin rashes, and bleeding, and the use of the drugs is limited, so it is not suitable or recommended for children and the elderly , pregnant women, lactating women take
In addition, existing medicines are often expensive

Method used

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  • Use of chlorophyll derivatives to improve muscle microcirculation disorder
  • Use of chlorophyll derivatives to improve muscle microcirculation disorder
  • Use of chlorophyll derivatives to improve muscle microcirculation disorder

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] Preparation of reference solution: Accurately weigh 0.143g of spectrally pure ferric oxide dried at 130°C to constant weight, put it in a beaker, add 5ml of hydrochloric acid solution (1→2) to dissolve, transfer to a 100ml measuring bottle, add Add 4ml of hydrochloric acid solution (1→2), add water to the mark, shake well, accurately measure 10ml, put it in a 100ml measuring bottle, add water to the mark, shake well to get a solution containing about 100μg of Fe per 1ml. Accurately measure 0, 0.2, 0.4, 0.6, 0.8 and 1.0ml of the above solutions respectively, put them in a 10ml measuring bottle, add nitric acid solution (1→500) to the mark, shake well, and you get it.

[0052] Preparation of the test solution: Take an appropriate amount of sample, grind it finely, accurately weigh 10mg, put it in a 50ml beaker, add 1.5ml of nitric acid, 3 drops of perchloric acid, cover with a watch glass, heat to nearly dry at 150-160°C, add Nitric acid (1→2) 2ml, cover with a watch glas...

Embodiment 1

[0086] Example 1 The protective effect of silkworm excrement extract on muscle acute microcirculation disturbance

[0087] According to the above-mentioned method, the iron chlorophyllin sodium weight percentage content is about 37.6%, and other chlorophyll derivatives are calculated as iron chlorophyllin (b) for more than 60.0% of the silkworm excrement, for its effect on rabbit muscle acute microcirculation disorder The role of the test, the results are as follows.

[0088] Table 1 The effect of silkworm excrement extract on the change rate of rabbit muscle microcirculation ( n=6)

[0089]

[0090] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0091] Table 1 shows that, compared with the negative control group, the change rate of blood perfusion (PU) in the high and middle dose groups of silkworm excrement extract was significantly reduced (P<0.01); The rate of change was significantly reduced (P<0.01). The change rate of blood cell velocity...

Embodiment 2

[0092] Example 2 The protective effect of silkworm excrement extract on acute microcirculation disturbance

[0093] Repeat the experiment of Example 1, the difference is that the iron chlorophyllin sodium iron chlorophyllate content is about 29.1% by weight, and other chlorophyll derivatives are tested with iron chlorophyllin (b) above 60.0% silkworm excrement. The results showed that blood perfusion (PU), blood cell aggregation (CMBC) and movement blood cell velocity (V) rate of change in the high, middle and low dose groups all decreased, indicating that the muscle microcirculation disorder of the tested rabbits was improved.

[0094] It can be known from the above examples that sodium ferric chlorophyllin and chlorophyll derivatives containing sodium ferric chlorophyllin (such as silkworm excrement) can effectively improve or regulate blood perfusion, concentration of moving blood cells and speed of moving blood cells, thereby improving muscle Acute microcirculation disorder,...

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Abstract

The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving muscle microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing muscle microcirculation disorders. The chlorophyll derivatives of the present invention, such as chlorophyll extracts and silkworm excrement extracts, have a good curative effect on improving muscle microcirculation disorders. The chlorophyll derivatives can also comprehensively prevent and improve muscle microcirculation disturbance through their functions in multiple links. Moreover, the toxic and side effects of the chlorophyll derivatives are improved, the applicable population is wide and safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, the preparation method of the chlorophyll derivative and the process applied to the preparation of medicine are relatively simple, and the cost is effectively controlled.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving muscle microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing muscle microcirculation disorders. Background technique [0002] Microcirculation refers to the blood circulation in capillaries between arterioles and venules. It is the part of the cardiovascular system in direct contact with tissue cells. The basic function of microcirculation is to carry out metabolism and material exchange. It is an important part of blood circulation and can be called the "second heart" of the human body. During the evolution process, organ microvessels and their parenchymal cells form a closely coordinated and highly adaptive three-dimensional structure. For the convenience of research, the configuration of organ microvessels is usually classified into hairpin type, dendrite typ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/555A61P7/00
CPCA61K31/555
Inventor 刘朝胜刘敏付雯吴瑜罗京余明森王根才周红晖袁建新徐发新
Owner 武汉联合药业有限责任公司
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