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A hemp hypolipidemic peptide composition and its application

A peptide composition and blood lipid-lowering technology, which is applied in the fields of application, drug combination, and protein composition of vegetable seeds, can solve the problems of waste of hemp seed resources, etc., to prevent cholesterol absorption, reduce blood cholesterol concentration, and significantly regulate blood lipids The effect of efficacy

Active Publication Date: 2022-05-03
DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in most hemp producing areas, hemp seeds are only used for the extraction of hemp seed oil, while the protein-rich hemp seed meal is discarded or used as feed, resulting in a waste of hemp seed resources

Method used

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  • A hemp hypolipidemic peptide composition and its application
  • A hemp hypolipidemic peptide composition and its application
  • A hemp hypolipidemic peptide composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A hemp lipid-lowering peptide composition mainly includes a pentapeptide with an amino acid sequence of Val-Ser-Glu-Pro-Arg and a hexapeptide with an amino acid sequence of Ile-Asp-Lys-Phe-Ser-Arg.

Embodiment 2

[0025] A hemp lipid-lowering peptide composition, mainly comprising a pentapeptide with an amino acid sequence of Val-Ser-Glu-Pro-Arg and a hexapeptide with an amino acid sequence of Ile-Asp-Lys-Phe-Ser-Arg, pentapeptide and hexapeptide The mass ratio of peptides was 4:5.

[0026] The molecular weight of the pentapeptide is 680 Da, the content of glutamic acid is 140.97 mg / g, the content of arginine is 89.0 mg / g, and the content of essential amino acids accounts for 25.19% of the total amino acids.

[0027] The molecular weight of hexapeptide is 876 Da.

Embodiment 3

[0029] This example provides a preparation method of hemp-lowering lipid peptide composition:

[0030] Mix hemp seed meal and distilled water according to a certain material-to-liquid ratio, add papain and neutral protease to the mixed solution, enzymolyze at a certain temperature to obtain an enzymatic hydrolyzate, raise the temperature to inactivate the enzyme, centrifuge the enzymatically hydrolyzate and take the supernatant , through a 1KD ultrafiltration membrane to obtain a hemp hypolipidemic peptide composition with a molecular weight of less than 1KD, and freeze-drying at a low temperature to obtain a hemp hypolipidemic peptide freeze-dried powder.

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Abstract

The invention belongs to the technical field of bioactive peptides, and in particular relates to a hemp-lowering blood lipid peptide composition and its application. In order to solve the problem of insufficient utilization of hemp seed meal resources, the present invention provides a hemp lipid-lowering peptide composition, comprising a pentapeptide with an amino acid sequence of Val-Ser-Glu-Pro-Arg in a mass ratio of 4:5 and The amino acid sequence is a hexapeptide of Ile-Asp-Lys-Phe-Ser-Arg. In the present invention, the content of glutamic acid and arginine in the small molecule peptide composition obtained by enzymatic hydrolysis and 1KD ultrafiltration membrane filtration of hemp seed meal is relatively high, and the special amino acid sequence enables the hemp blood lipid-lowering peptide composition to be absorbed and metabolized by the human body The hemp-lowering lipid peptide composition of the present invention is applied to blood-lipid-lowering medicines, health food and food additives, which can hinder the absorption of cholesterol in the intestinal tract, promote the excretion of cholesterol, thereby reducing blood cholesterol concentration .

Description

technical field [0001] The invention belongs to the technical field of bioactive peptides, and in particular relates to a hemp-lowering blood lipid peptide composition and its application. Background technique [0002] Dyslipidemia is one of the independent and important risk factors for cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction and ischemic stroke, which seriously endangers human health. At present, chemical drugs such as acipimox, simvastatin, and cholestyramine are often used clinically for the treatment of hyperlipidemia. Although they have good curative effects, long-term use will cause many adverse reactions such as liver and kidney damage, rhabdomyolysis, and the like. Therefore, it has become a new trend for domestic and foreign scholars to screen safe and non-side-effect hypolipidemic active substances from natural animal and plant resources. [0003] Bioactive peptides refer to peptide compounds that are bene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A23J1/14A23J3/34A23J3/14A23L33/18A61K38/08A61P3/06
CPCA23J1/148A23J3/346A23J3/14A23L33/18C07K7/06A61K38/08A61P3/06A23V2002/00A23V2200/3262A23V2250/55A61K2300/00
Inventor 宋淑敏魏连会潘静董艳石杰高媛赫大新夏尊民高宇
Owner DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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