Cannabis sativa blood-fat-reducing peptide composition and application thereof

A peptide composition and a blood lipid-lowering technology are applied in the directions of application, drug combination, protein composition of vegetable seeds, etc., which can solve the problems of hemp seed resource waste and the like, and achieve the advantages of being suitable for large-scale production, simple preparation process, and improving additional effect of value

Active Publication Date: 2019-08-09
DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in most hemp producing areas, hemp seeds are only used for the extraction of hemp seed oil, w

Method used

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  • Cannabis sativa blood-fat-reducing peptide composition and application thereof
  • Cannabis sativa blood-fat-reducing peptide composition and application thereof
  • Cannabis sativa blood-fat-reducing peptide composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A hemp lipid-lowering peptide composition mainly includes a pentapeptide with an amino acid sequence of Val-Ser-Glu-Pro-Arg and a hexapeptide with an amino acid sequence of Ile-Asp-Lys-Phe-Ser-Arg.

Embodiment 2

[0025] A hemp lipid-lowering peptide composition, mainly comprising a pentapeptide with an amino acid sequence of Val-Ser-Glu-Pro-Arg and a hexapeptide with an amino acid sequence of Ile-Asp-Lys-Phe-Ser-Arg, pentapeptide and hexapeptide The mass ratio of peptides is 4:5.

[0026] The molecular weight of the pentapeptide is 680 Da, the content of glutamic acid is 140.97 mg / g, the content of arginine is 89.0 mg / g, and the content of essential amino acids accounts for 25.19% of the total amino acids.

[0027] The molecular weight of hexapeptide is 876 Da.

Embodiment 3

[0029] This example provides a preparation method of hemp-lowering lipid peptide composition:

[0030] Mix hemp seed meal and distilled water according to a certain material-to-liquid ratio, add papain and neutral protease to the mixed solution, enzymolyze at a certain temperature to obtain an enzymatic hydrolyzate, raise the temperature to inactivate the enzyme, centrifuge the enzymatically hydrolyzate and take the supernatant , through a 1KD ultrafiltration membrane to obtain a hemp hypolipidemic peptide composition with a molecular weight of less than 1KD, and freeze-drying at a low temperature to obtain a hemp hypolipidemic peptide freeze-dried powder.

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Abstract

The invention belongs to the technical field of biological active peptides, and particularly relates to a cannabis sativa blood-fat-reducing peptide composition and application thereof. To solve the problem that cannabis sativa seed meal resources are under utilization, the cannabis sativa blood-fat-reducing peptide composition is provided. The cannabis sativa blood-fat-reducing peptide composition comprises a pentapeptide with the amino acid sequence of Val-Ser-Glu-Pro-Arg and a hexapeptide with the amino acid sequence of Ile-Asp-Lys-Phe-Ser-Arg, wherein the mass ratio of the pentapeptide tothe hexapeptide is 4:5. According to the cannabis sativa blood-fat-reducing peptide composition and the application thereof, cannabis sativa seed meal is subjected to enzymolysis and filtered by a 1KDultrafiltration membrane to obtain the small molecule peptide composition, the content of glutamic acid and arginine in the composition is high, and through the special amino acid sequences, the cannabis sativa blood-fat-reducing peptide composition has a significant function of blood fat adjustment during absorption and metabolism of the human body. The cannabis sativa blood-fat-reducing peptidecomposition is applied to blood-fat-reducing drugs, health-care foods and food additives, and can hinder cholesterol absorption in the intestinal tracts, and promote the process of discharging cholesterol out of the body, and thus the concentration of the serum cholesterol is lowered.

Description

technical field [0001] The invention belongs to the technical field of bioactive peptides, and in particular relates to a hemp-lowering blood lipid peptide composition and its application. Background technique [0002] Dyslipidemia is one of the independent and important risk factors for cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction and ischemic stroke, which seriously endangers human health. At present, chemical drugs such as acipimox, simvastatin, and cholestyramine are often used clinically for the treatment of hyperlipidemia. Although they have good curative effects, long-term use will cause many adverse reactions such as liver and kidney damage, rhabdomyolysis, and the like. Therefore, it has become a new trend for domestic and foreign scholars to screen safe and non-side-effect hypolipidemic active substances from natural animal and plant resources. [0003] Bioactive peptides refer to peptide compounds that are bene...

Claims

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Application Information

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IPC IPC(8): A23J1/14A23J3/34A23J3/14A23L33/18C07K7/06A61K38/08A61P3/06
CPCA23J1/148A23J3/346A23J3/14A23L33/18C07K7/06A61K38/08A61P3/06A23V2002/00A23V2200/3262A23V2250/55A61K2300/00
Inventor 宋淑敏魏连会潘静董艳石杰高媛赫大新夏尊民高宇
Owner DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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