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Preparation method of venation-dredging preparation

A technology for Mailuoshutong and preparations, which is applied in the new preparation field of Mailuoshutong preparations, can solve problems such as affecting the compliance of patients with medication, and achieve the effects of avoiding nausea, improving compliance, and reducing fishy odor.

Inactive Publication Date: 2019-08-16
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many shortcomings and deficiencies in the existing preparation methods of Mailuoshutong preparations. For example, in the original preparation method, 1 / 2 of the formula amount of animal medicinal materials is directly used as the original powder of animal medicinal materials without extraction steps, resulting in a strong fishy smell in Mailuoshutong preparations. Taste, patients may have reactions such as nausea and vomiting when taking it, which will affect the patient's compliance with medication

Method used

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  • Preparation method of venation-dredging preparation
  • Preparation method of venation-dredging preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0265] The preparation of embodiment 1 granule

[0266] 1) Take astragalus, honeysuckle, phellodendron, herb, coix seed, scrophulariaceae, angelica, white peony root, licorice, leech, centipede, and scorpion 12 kinds of raw materials, of which astragalus and licorice are sliced ​​for use; Danggui and Baishao cut into sections, set aside; honeysuckle, coix seed, centipede, scorpion, and leech cleaned, set aside;

[0267] 2) Step 1) Mix 0.20 kg of Atractylodes atractylodes segment and 0.20 kg of Angelica sinensis slices, distill to extract volatile oil, add β-cyclodextrin to the obtained volatile oil to make β-cyclodextrin inclusion compound, and set aside; the distilled aqueous solution is separated Store for future use; Distilled medicinal residue Ⅰ for future use;

[0268] 3) Take 0.18 kg of leeches, 0.04 kg of centipedes, and 0.05 kg of scorpions obtained in step 1), and extract 3 times with 80% ethanol under reflux, each time for 1 hour, combine the extracts, centrifuge, a...

Embodiment 2

[0272] The preparation of embodiment 2 capsules

[0273] 1) Take astragalus, honeysuckle, phellodendron, herb, coix seed, scrophulariaceae, angelica, white peony root, licorice, leech, centipede, and scorpion 12 kinds of raw materials, of which astragalus and licorice are sliced ​​for use; Danggui and Baishao cut into sections, set aside; honeysuckle, coix seed, centipede, scorpion, and leech cleaned, set aside;

[0274] 2) Mix 0.27 kg of Atractylodes atractylodis segment and 0.28 kg of Angelica sinensis slices obtained in step 1, distill and extract the volatile oil, add hydroxypropyl-β-cyclodextrin to the obtained volatile oil to make a hydroxypropyl-β-cyclodextrin inclusion compound, Standby; the distilled aqueous solution is stored in another container for future use; medicinal residue I obtained by distillation is for future use;

[0275] 3) Take 0.21 kg of leeches, 0.03 kg of centipedes, and 0.07 kg of scorpions obtained in step 1), and extract them twice with 70% ethan...

Embodiment 3

[0279] The preparation of embodiment 3 tablet

[0280] 1) Take astragalus, honeysuckle, phellodendron, herb, coix seed, scrophulariaceae, angelica, white peony root, licorice, leech, centipede, and scorpion 12 kinds of raw materials, of which astragalus and licorice are sliced ​​for use; Danggui and Baishao cut into sections, set aside; honeysuckle, coix seed, centipede, scorpion, and leech cleaned, set aside;

[0281] 2) Mix 0.25 kg of Atractylodes atractylodis and 0.25 kg of Angelica Sinensis obtained in step 1, distill and extract the volatile oil, add γ-cyclodextrin to the obtained volatile oil to make γ-cyclodextrin inclusion compound, and set aside; the distilled aqueous solution is separated Store for future use; Distilled medicinal residue Ⅰ for future use;

[0282] 3) Take 0.22 kg of leeches, 0.03 kg of centipedes, and 0.09 kg of scorpions obtained in step 1), and extract once with 60% ethanol under reflux for 3 hours each time, combine the extracts, centrifuge, and ...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method of a venation-dredging preparation. The preparation method improves the content of three kinds of iconic medicinal components of chlorogenic acid, astragaloside IV and berberine hydrochloride in the venation-dredging preparation, the extraction amount of Chinese angelica and rhizoma atractylodis volatile oil is improved, and the clinical efficacy of the product is ensured; at the same time, the three kinds of precious animal medicinal materials of leeches, centipedes and scorpion are extracted by a double extraction method of alcohol-refluxing and water-adding decoction, which can ensure the comprehensive and full extraction of water-soluble and alcohol-solublecomponents in animal medicinal materials, the preparation reduces the content of ineffective impurities in the preparation, reduces the dosage, improves the taste, and improves the compliance of patient administration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a new preparation method of Mailuoshutong preparation. Background technique [0002] Thrombophlebitis refers to acute non-suppurative inflammation in the venous lumen, accompanied by thrombosis. It is a common vascular thrombotic disease, and the lesions mainly involve the superficial and deep veins of the extremities. Thrombosis can cause inflammation, and inflammation can also cause thrombus. The two cause and effect each other, which is a common clinical difficult disease. Thrombophlebitis is still in the exploratory stage at home and abroad. Antibiotics and alkylating agents can damage the venous intima to varying degrees, leading to thrombus formation; anticoagulant therapy cannot completely dissolve the formed thrombus; injection therapy has a limited scope of application There are many deficiencies. At present, there is a lack of safe,...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K47/69A61P9/14A61P7/02A61K35/62A61K35/646A61K35/648
CPCA61K35/62A61K35/646A61K35/648A61K36/232A61K36/284A61K36/355A61K36/481A61K36/484A61K36/65A61K36/71A61K36/756A61K36/808A61K36/8994A61K2236/331A61K2236/333A61K2236/39A61K47/6951A61P7/02A61P9/14A61K2300/00
Inventor 张贵民王永刚刘鹏
Owner LUNAN PHARMA GROUP CORPORATION
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