Method for improving structural stability of biological material and biological material

A biomaterial and structurally stable technology, applied in the field of biomedical materials and medical devices, can solve the problems of lack of active amino groups and lack of good quality, and achieve the effect of improving stability and anti-calcification performance.

Inactive Publication Date: 2019-08-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, glutaraldehyde-crosslinked biological heart valves are prone to degradation and calcification, resulting in only about 10 years of effective use of biological heart valves
Glutaraldehyde can achieve stable cross-linking of collagen, but because the elastin in animal pericardial tissue lacks active amino groups that can react with glutaraldehyde, it has certain technical limitations.
[0007] Therefore, by optimizing the chemical cross-linkin...

Method used

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  • Method for improving structural stability of biological material and biological material
  • Method for improving structural stability of biological material and biological material
  • Method for improving structural stability of biological material and biological material

Examples

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Embodiment 1

[0039] This example provides a treatment method for improving the structural stabilization performance of biological materials. In all embodiments, the fresh pig pericardium comes from a local slaughterhouse. Glutaraldehyde, ferric chloride and elastase were from Chengdu Best Reagent Company. Tannic acid and epigallocatechin gallate were from Sigma-Aldrich.

[0040] Such as figure 1 As shown, the processing method provided in this embodiment includes the following steps:

[0041] S1. Obtain biological materials;

[0042] S2, soak and clean with distilled water;

[0043] S3, then soaking the biological material cleaned in step S2 in an aqueous solution of tea polyphenols with a mass solubility of 0.1-1%;

[0044] S4, then immersing the biological material treated in step S3 in an aqueous solution of metal ions with a mass solubility of 0.1-10%;

[0045] S5, then soak and clean the biological material completed in step S4 with distilled water again;

[0046] S6. Soak the b...

Embodiment 2

[0073] This example provides a treatment method for improving the structural stabilization performance of biological materials. In all embodiments, the fresh pig pericardium comes from a local slaughterhouse. Glutaraldehyde, ferric chloride and elastase were from Chengdu Best Reagent Company. Tannic acid and epigallocatechin gallate were from Sigma-Aldrich.

[0074] The processing method provided by the present embodiment includes the following steps:

[0075] S1. Obtain biological materials;

[0076] S2, soak and clean with distilled water;

[0077] S3, then soaking the biological material cleaned in step S2 in an aqueous solution of tea polyphenols with a mass solubility of 0.5%;

[0078] S4, then immersing the biological material treated in step S3 in an aqueous solution of metal ions with a mass solubility of 1%;

[0079] S5, then soak and clean the biological material completed in step S4 with distilled water again;

[0080] S6. Soak the biological material completed...

Embodiment 3

[0083] This example provides a treatment method for improving the structural stabilization performance of biological materials. In all embodiments, the fresh pig pericardium comes from a local slaughterhouse. Glutaraldehyde, ferric chloride and elastase were from Chengdu Best Reagent Company. Tannic acid and epigallocatechin gallate were from Sigma-Aldrich.

[0084] The processing method provided by the present embodiment includes the following steps:

[0085] S1. Obtain biological materials;

[0086] S2, soak and clean with distilled water;

[0087] S3, then soaking the biological material cleaned in step S2 in an aqueous solution of tea polyphenols with a mass solubility of 0.1%;

[0088] S4, then immersing the biological material treated in step S3 in an aqueous solution of metal ions with a mass solubility of 0.1%;

[0089] S5, then soak and clean the biological material completed in step S4 with distilled water again;

[0090] S6. Soak the biological material complet...

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Abstract

The invention discloses a method for improving the structural stability of a biological material and the biological material. The method comprises the steps of soaking the biological material in an aqueous solution of tea polyphenol and metal ions, and adsorbing the tea polyphenol on hydrophobic sections of elastin fibers under the function of hydrogen bonds. In this way, the structural stabilityof elastin is improved, the metal ions and calcium ions conduct competitive binding to adsorb the tea polyphenol, and thus the calcification of the biological material is inhibited. By means of the method, the structural stability and anti-calcification performance of the biological material can be improved, and the service life of the biological material is potentially prolonged.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and medical devices, in particular to a treatment method for improving the structural stability of biomaterials and the biomaterials thereof. Background technique [0002] Heart valve disease is a common disease of valve degeneration. Anatomically, it manifests as narrowing of the blood passage or valvular insufficiency. [0003] Treatment of heart valve disease includes open heart valve replacement surgery and percutaneous heart valve replacement surgery. Thoracotomy is traumatic, high-risk, slow recovery, and requires extracorporeal circulation support, which is unacceptable to many patients. Percutaneous heart valve replacement surgery has become the main trend of valve surgery in the future because of its small trauma and low risk to patients. [0004] Biological heart valves refer to a class of biomedical materials used to replace human diseased heart valves. Biological heart...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/04A61L27/50A61L27/60A61L27/24A61L27/22A61L27/20
CPCA61L27/04A61L27/20A61L27/222A61L27/227A61L27/24A61L27/362A61L27/3625A61L27/3633A61L27/3637A61L27/3687A61L27/3691A61L27/50A61L27/507A61L27/60A61L2430/20A61L2430/40C08L89/00C08L5/08
Inventor 王云兵雷洋
Owner SICHUAN UNIV
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