Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A valve material with long-acting antithrombotic performance and its preparation method

An anti-thrombotic and valve technology, applied in the field of valve materials with long-term anti-thrombotic performance and its preparation, can solve the problems of easy calcification and thrombus formation, avoid calcium ion residues, improve anti-calcification performance, and improve anticoagulant function Effect

Active Publication Date: 2021-03-30
VENUS MEDTECH (HANGZHOU) INC
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned problems in the prior art, the present invention provides a valve material with long-term antithrombotic properties and a preparation method thereof. The valve material prepared by this method can effectively solve the problem of the existing glutaraldehyde cross-linking method. The problems of easy calcification and thrombus formation in the existing valve material, the valve material prepared according to this method can be used in aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A valve material with long-acting antithrombotic performance and its preparation method
  • A valve material with long-acting antithrombotic performance and its preparation method
  • A valve material with long-acting antithrombotic performance and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A valve material with long-acting antithrombotic properties, the preparation method of which comprises the following steps:

[0033] (1) Cut the degreased pig pericardium material into a suitable size, soak it in 1% glutaraldehyde solution after stretching, change the solution every 24 hours, and continue the treatment for 72 hours;

[0034] (2) After cleaning the cross-linked valve material obtained above, immerse it in the formula solution for 30 minutes, the formula solution solvent is hexafluoroisopropanol, the cross-linking agent is sodium hexametaphosphate, and the modifier is glycerophosphocholine, The concentrations of sodium hexametaphosphate and glycerophosphorylcholine are 1 wt% and 0.5 wt%, respectively, and then the valve infiltrated by the formula solution is heated to 40 degrees, and heat-treated for 4 hours;

[0035] (3) The valve material obtained in step 2 is fully washed with deionized water to obtain the target valve material, and the material is sto...

Embodiment 2

[0037] A valve material with long-acting antithrombotic properties, the preparation method of which comprises the following steps:

[0038] (1) Cut the pig pericardium material after degreasing into suitable size, immerse in 0.5% glutaraldehyde solution for treatment for 24 hours after stretching, then transfer to 1% glutaraldehyde solution for treatment for 48 hours;

[0039] (2) After cleaning the cross-linked valve material obtained above, immerse it in the formula solution for 60 minutes, the formula solution solvent is isopropanol, the cross-linking agent is isocyanate, and the modifier is methacryloyl ethyl sulfobeet Alkali, lauryl methacrylate, butyl methacrylate copolymer, isocyanate, methacryloyl ethyl sulfobetaine, lauryl methacrylate, butyl methacrylate copolymer at concentrations of 0.1 wt%, 0.1wt%, 0.2wt% and 0.2wt%, then the valve infiltrated by the formula liquid was heated to 60 degrees, and heat treated for 3h;

[0040] (3) The valve material obtained in step...

Embodiment 3

[0042] A valve material with long-acting antithrombotic properties, the preparation method of which comprises the following steps:

[0043] (1) Cut the degreased bovine pericardium material into a suitable size, immerse it in 1% glutaraldehyde solution for 24 hours after stretching, and then transfer to 0.5% glutaraldehyde solution for 48 hours;

[0044] (2) After cleaning the cross-linked valve material obtained above, immerse it in the formula solution for 20 minutes, the formula solution solvent is water, the cross-linking agent is sodium metaphosphate, and the modifier is lauryl methacrylate, 2-(methyl Acryloyloxy)ethyl-2-(trimethylamino)ethyl phosphate copolymer, sodium metaphosphate, lauryl methacrylate, 2-(methacryloyloxy)ethyl-2- The concentrations of the (trimethylamino)ethyl phosphate copolymers were 1 wt%, 0.2 wt% and 0.3 wt%, respectively, and then the valve soaked in the formula liquid was heated to 50 degrees, and heat-treated for 8 hours;

[0045] (3) Fully was...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a valve material with long-acting antithrombotic performance and a preparation method thereof. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on the animal-source biological valve material, so that the valve material can resist corruption for a long time; The treated valve material is soaked in a formula solution containing a cross-linking agent and a modifier for 10-60 minutes, then heated to 30-60° C., and heat-treated for 1-12 hours; the heat-treated valve material is rinsed to obtain the preparation. The valve material prepared by this method has excellent anti-thrombotic and anti-calcification properties, which can effectively solve the problems of easy calcification and thrombus formation in the existing valve materials processed by glutaraldehyde cross-linking. The valve material can be used as the valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.

Description

technical field [0001] The invention belongs to the technical field of modification of biomedical materials and medical devices, and in particular relates to a valve material with long-acting antithrombotic performance and a preparation method thereof. The valve material prepared according to the method can be used for aortic valve and pulmonary valve , Valve materials required for venous valve, mitral valve and tricuspid valve replacement. Background technique [0002] Heart valve disease (HVD) is a type of disease that affects the normal flow of blood due to the abnormality of the human body's own valves, resulting in abnormal heart function. With economic development and population aging, the incidence of heart valve disease is on the rise. According to incomplete statistics, in China, only about 200,000 new patients with aortic valve disease are added each year. The incidence of valvular heart disease in the elderly in my country is as high as 13.3%, second only to hype...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/54A61L27/56A61L33/00A61L33/04
CPCA61L27/3625A61L27/3687A61L27/3629A61L27/56A61L33/04A61L33/0082A61L27/54A61L33/0041A61L2400/18A61L2430/20A61L2430/40A61L2300/22
Inventor 王云兵罗日方杨立张凡军
Owner VENUS MEDTECH (HANGZHOU) INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com