Sitafloxacin microcapsule preparation and preparation method thereof
A sitafloxacin and preparation technology, applied in the field of sitafloxacin microcapsule preparation and its preparation, can solve the problems of uneven particles, unstable dissolution, poor bitterness masking effect, etc., achieve stable disintegration and dissolution, and improve drug Compliance, the effect of improving drug safety
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Embodiment 1
[0042] Embodiment 1, the preparation of sitafloxacin microcapsule tablet
[0043] The preparation raw materials include: 35g of sitafloxacin, 20g of gelatin, 25g of hydroxyethyl cellulose, 10g of croscarmellose sodium, 10g of microcrystalline cellulose, 10g of lactose, and 90g of 70% ethanol aqueous solution;
[0044] The process preparation method specifically includes:
[0045] Step 1, add the sitafloxacin of 35g in the fluidized bed, pass into air and make it suspend;
[0046] Step 2, mix 20g of gelatin, 25g of hydroxyethyl cellulose and 90g of 70% ethanol aqueous solution to obtain a capsule material solution, the capsule material solution is atomized and passed into a fluidized bed suspended with sitafloxacin, and the capsule material solution is passed into The conveying speed of fluidized bed is 50r / min, drying, crosses 800 mesh sieves and obtains sitafloxacin microcapsule core;
[0047] Step 3. Mix the sitafloxacin microcapsule core obtained in step 2 with 10 g of cr...
Embodiment 2
[0048] Embodiment 2, the preparation of sitafloxacin microcapsule capsule
[0049] The preparation raw materials include: 45g of sitafloxacin, 25g of polyvinyl alcohol, 30g of carboxymethylcellulose, 15g of low-substituted hydroxypropyl cellulose, 10g of starch, 5g of sucrose, and 100g of 70% ethanol aqueous solution;
[0050] The process preparation method specifically includes:
[0051] Step 1, add the sitafloxacin of 45g in the fluidized bed, pass into air and make it suspend;
[0052] Step 2, mix 25g of polyvinyl alcohol, 30g of carboxymethyl cellulose and 100g of 70% ethanol aqueous solution to obtain a capsule material solution, the capsule material solution is sprayed into a fluidized bed suspended with sitafloxacin, and the capsule material solution The conveying speed of passing into fluidized bed is 50r / min, dry, cross 800 mesh sieves and obtain sitafloxacin microcapsule core;
[0053] Step 3. Mix the sitafloxacin microcapsule core obtained in step 2 with 15 g of l...
Embodiment 3
[0054]Embodiment 3, preparation of sitafloxacin microcapsule granules
[0055] The preparation raw materials include: 40g of sitafloxacin, 50g of polyvinylpyrrolidone, 5g of copovidone, 10g of microcrystalline cellulose, and 100g of 70% ethanol aqueous solution;
[0056] The process preparation method specifically includes:
[0057] Step 1, add the sitafloxacin of 40g in the fluidized bed, pass into air and make it suspend;
[0058] Step 2. Mix 50 g of polyvinylpyrrolidone and 100 g of 70% ethanol aqueous solution to obtain a capsule material solution. The capsule material solution is atomized and passed into a fluidized bed suspended with sitafloxacin, and the capsule material solution is passed into the fluidized bed for transportation Speed is 50r / min, dry, pass through 800 mesh sieves to obtain sitafloxacin microcapsule core;
[0059] Step 3. Mix the sitafloxacin microcapsule core obtained in step 2 with 5 g of copovidone and 10 g of microcrystalline cellulose, granula...
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