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Application of gastrodin in preparing drugs for treating cerebral hemorrhage

A gastrodin and drug technology, applied in the field of medicine, can solve problems such as hemorrhagic transformation that has not yet been seen

Pending Publication Date: 2019-08-30
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report about the use of gastrodin to reduce hemorrhagic transformation after rt-PA thrombolytic therapy in acute ischemic stroke

Method used

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  • Application of gastrodin in preparing drugs for treating cerebral hemorrhage
  • Application of gastrodin in preparing drugs for treating cerebral hemorrhage
  • Application of gastrodin in preparing drugs for treating cerebral hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Study on the protective effect of gastrodin on hemorrhagic transformation in rats with cerebral ischemia-reperfusion induced by rt-PA

[0050] 1. Reagents and animals

[0051] 1.1 Test product: gastrodin injection, Kunming Pharmaceutical Group Co., Ltd., traits: colorless transparent liquid; specification: 2mL: 0.2g / bottle; batch number 17JX06-222; storage conditions: room temperature, dark; expiration date: 2020.09;

[0052] 1.2 Reference substance: name or code: alteplase (rt-PA); Boehringer Ingelheim (Germany); traits: off-white loose lumps; specification: 20mg / bottle (including diluent); batch number: 703948; storage conditions: 2 ~ 8 ℃, airtight, away from light; validity period: 2020.02;

[0053] 1.3 Other reagents: Hemoglobin Quantitative Kit (BioAssay Systems, USA, Cat: DIHB-250); MMP9 ELISA Detection Kit (R&D, USA, Cat: RMP900); Rat Cytokine / Chemokine (TNF-α, IL-6, IL -12(p70), IL-1beta) liquid phase chip, manufacturer: Millipore, USA, Cat: RECYTNA...

Embodiment 2

[0127] Example 2: Study on the protective effect and mechanism of gastrodin on HBMEC induced by OGD

[0128] 1. Experimental materials

[0129] 1.1 Test product: gastrodin injection, Kunming Pharmaceutical Group Co., Ltd., traits: colorless transparent liquid; specification: 2mL: 0.2g / bottle; batch number 17JX06-222; storage conditions: room temperature, dark; expiration date: 2020.09;

[0130] 1.2 Reference substance: name or code: nimodipine injection, batch number: 180320, specification: 20mL: 4mg, Yabao Pharmaceutical.

[0131] 1.3 Experimental cells: human brain microvascular endothelial cell line (HBMEC), purchased from Guangzhou Geneo Biotechnology Co., Ltd.

[0132] 1.4 Other reagents: endothelial cell medium (ECM), ScienCell; high-sugar DMEM basal medium, sugar-free DMEM basal medium, DPBS Duchenne's phosphate buffer, PBS phosphate buffer, fetal bovine serum (FBS), 0.25% Trypsin- EDTA (1X) was purchased from Gibco; penicillin-streptomycin (double antibody), BI; dime...

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Abstract

The present invention relates to the technical field of medicines, specifically relates to a use of gastrodin in preparing drugs for cerebral hemorrhage, particularly provides a use in preparing the drugs for reducing hemorrhagic transformation caused after a cerebral ischemia rt-PA thrombolytic therapy, and provides the use of the gastrodin in preparing the drugs for reducing the hemorrhagic transformation caused after the cerebral ischemia rt-PA thrombolytic therapy. The use suggests that a clinical early use of an gastrodin injection has a certain inhibitory effect for the existing hemorrhagic transformation caused by the use of the rt-PA thrombolytic therapy to treat ischemic stroke, can relatively extend time window of the rt-PA thrombolytic therapy, strives for more treatment time for patients with the clinical cerebral stroke, further reduces damages to central nervous system, enables prognosis to be better, reduces occurrence of sequelae and improves life quality of the patients.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of gastrodin in the preparation of cerebral hemorrhage drugs, especially the use in the preparation of drugs for reducing hemorrhage transformation caused by cerebral ischemia after rt-PA thrombolytic therapy. Background technique [0002] It is well known that intravenous thrombolysis is the only effective method for the treatment of acute ischemic stroke, its safety and effectiveness have been recognized, and it is recommended by multinational guidelines [Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS.ECASS.and NINDS rt-PA stroketrials[J].Lancet,2004,363(9411):768-774.]. At present, domestic and foreign guidelines unanimously recommend intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) as the best solution for the treatment of acute ischemic stroke, and treatment with...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K38/49A61P7/04A61P9/10
CPCA61K31/7034A61K38/49C12Y304/21068A61P7/04A61P9/10
Inventor 杨兆祥刘一丹杨旭娟刘国光尚建华刘军锋
Owner KPC PHARM INC
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