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Nano composite hydrogel and preparation method and application thereof

A nanocomposite and hydrogel technology, applied in the field of hydrogel, can solve the problems of low mechanical strength and insufficient toughness of composite hydrogel, achieve injectability, increase mechanical strength and toughness, and improve storage modulus Effect

Active Publication Date: 2019-09-03
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of low mechanical strength and insufficient toughness of the composite hydrogel in the prior art, the present invention increases mechanical strength and toughness by transferring mechanical force within the crosslinked network through covalent crosslinking between polymers and nanoparticles

Method used

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  • Nano composite hydrogel and preparation method and application thereof
  • Nano composite hydrogel and preparation method and application thereof
  • Nano composite hydrogel and preparation method and application thereof

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Embodiment 1

[0071] A method for preparing a nanocomposite hydrogel or a method for preparing a nanocomposite hydrogel described in the first embodiment, the method comprises the following steps:

[0072] (1) Synthesis of a polymer containing phenylboronic acid: dissolve the substance containing phenylboronic acid in a solvent, add a chain transfer agent and an initiator, and react to obtain a polymer containing phenylboronic acid;

[0073] (2) Synthesis of polymers containing diols: Dissolving substances containing 1,2-diols or 1,3-diols in solvents, adding chain transfer agents and initiators, and reacting to obtain diol-containing polymers polymer;

[0074] (3) Synthesis of polydopamine-coated and modified nanoparticles: disperse the nanoparticles in a buffer solution, add dopamine, stir and react for a period of time, separate the solid, and obtain polydopamine-coated and modified nanoparticles;

[0075] (4) Preparation of nanocomposite hydrogel: dissolve the polydopamine-coated and m...

Embodiment 2

[0077] A method for preparing a nanocomposite hydrogel with pH response, self-healing, self-adhesive and injectable properties, the method comprising the following steps:

[0078] (1) Synthesis of polymers containing phenylboronic acid: APBA and GMA monomers, DMF and H 2 The mixed solvent of O, the chain transfer agent EMP and the initiator AIBN are added to the round bottom flask, and the round bottom flask is sealed after blowing nitrogen and deoxygenating, and reacted at a constant temperature in an oil bath. After a period of time, liquid nitrogen is quenched to stop the reaction. DMF was diluted and settled with ether, and the obtained product was vacuum-dried at room temperature;

[0079] (2) Synthesis of polymers containing diols: GMA monomer, chain transfer agent EMP, initiator AIBN and solvent DMF are added to the round-bottomed flask, and the round-bottomed flask is sealed after blowing nitrogen and oxygen, and placed in an oil bath Constant temperature reaction, af...

Embodiment 3

[0083] A method for preparing a nanocomposite hydrogel with pH response, self-healing, self-adhesive and injectable properties, the method comprising the following steps:

[0084] (1) PAPBA-stat-PDMA synthesis: 90mg EMP (0.4mmol RAFT group), DMA (3.172g, 32mmol), APBA (1.528g, 8mmol), AIBN (6.56mg, 0.04mmol), 19mL fresh DMF and 1mL H 2 O was added to a dry round-bottomed flask; nitrogen was blown in to vent the oxygen in the reactor, the flask was sealed, and then immersed in an oil bath at 70°C; after 2 hours, the polymerization reaction was terminated by liquid nitrogen; after cooling to room temperature, the polymerization The substance is diluted with DMF; the polymer is precipitated in anhydrous ether to obtain a polymer containing phenylboronic acid;

[0085] (2) PGMA synthesis: put 45.0mg EMP (0.2mmol RAFT group), GMA (3.2g, 20mmol), AIBN (3.28mg, 0.02mmol), 16mL fresh DMF into a dry round bottom flask; blow nitrogen , the oxygen in the reactor was vented, the flask wa...

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Abstract

The invention designs a novel multifunctional nano composite hydrogel, which has injectability, self-healing, and good mechanical strength, irritant reaction and adhesiveness. The multifunctional nanocomposite hydrogel is prepared by using a diol-containing polymer (PGMA) and a phenylboronic acid-containing polymer (PAPBA-STAT-PDMA) as precursors and adding a certain amount of poly-dopamine-coatedmodified nanoparticles (rGO @ PDA). In alkaline environment, a hydrogel network can be easily realized through the interaction of the phenylboronic acid- containing polymer and the diol- containing polymer. Compared with a pure polymer hydrogel without the poly-dopamine- coated modified nanoparticles (rGO @ PDA), the storage modulus (G') of the obtained nanocomposite hydrogel is significantly improved, and the nanocomposite hydrogel has adhesiveness.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a pH-responsive, self-repairing, self-adhesive, injectable nanocomposite hydrogel and its preparation method and use, belonging to the field of biomedical material preparation. Background technique [0002] Hydrogels are three-dimensional network structures composed of hydrophilic polymer chains. It has broad application prospects in physical, chemical, biological and highly biocompatible drug release. Despite the many advantages of hydrogels, there are still some drawbacks. Such as low mechanical strength, poor mechanical properties, single performance, poor stability, etc. These defects limit the application of hydrogels in various fields. For these reasons, researchers have designed and developed novel hydrogels to overcome hydrogel defects while endowing hydrogels with some unique properties. With the improvement of the mechanical properties of hydrogels, many strategies for preparing hydrog...

Claims

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Application Information

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IPC IPC(8): C08L33/24C08L39/06C08L33/02C08L33/26C08L71/02C08L29/04C08L33/14C08K9/10C08K3/04C08K3/36C08K3/34C08J3/075C08F120/20
CPCC08F120/20C08F220/54C08G73/0672C08J3/075C08J3/24C08J3/246C08J2333/24C08J2433/14C08K9/10C08K2201/011C08K3/042
Inventor 高勇黄伟伟
Owner XIANGTAN UNIV
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