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Osteogenesis promoting rubidium-titanium-tantalum-containing composite material, preparation method thereof and application of composite material

A composite material and bone-promoting technology, which is applied in the fields of pharmaceutical formula, medical science, and prostheses, can solve problems such as poor biological activity and surgical failure, and achieve the effects of optimizing biological activity, improving biological performance, and enhancing bonding strength

Active Publication Date: 2019-09-06
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem in the prior art that the medical titanium-tantalum composite material has poor biological activity and is likely to cause operation failure in actual clinical application, the purpose of the present invention is to provide a bone-promoting rubidium-titanium-tantalum composite material with excellent mechanical properties and biological activity. Materials and their preparation methods and applications

Method used

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  • Osteogenesis promoting rubidium-titanium-tantalum-containing composite material, preparation method thereof and application of composite material
  • Osteogenesis promoting rubidium-titanium-tantalum-containing composite material, preparation method thereof and application of composite material
  • Osteogenesis promoting rubidium-titanium-tantalum-containing composite material, preparation method thereof and application of composite material

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Effect test

Embodiment 1

[0041]Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:30; then put the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering, and the sintering is completed to obtain a titanium-tantalum composite Materials, the sintering procedure is as follows: the heating rate is 70°C / min, the sintering temperature is 1000°C, the sintering time is 5min; the sintering pressure is 60MPa.

[0042] The titanium-tantalum composite material was subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 70°C for 28 hours, wherein the acid solution was composed of hydrochloric acid (mass fraction: 38%), sulfuric acid (mass fraction: 96%) and water in a volume ratio of 7:7:8 mixed to get. Put the acid-treated titanium-tantalum composite material in 4M potassium hydroxide solution, and perform alkali heat treatment at 70°C for 28 hours; then w...

Embodiment 2

[0065] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then put the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering, and the sintering is completed to obtain a titanium-tantalum composite Materials, the sintering procedure is as follows: the heating rate is 50°C / min, the sintering temperature is 1300°C, the sintering time is 5min; the sintering pressure is 30MPa.

[0066] The titanium-tantalum composite material is subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution is composed of hydrochloric acid (mass fraction: 37% write specific value), sulfuric acid (mass fraction: 95% write specific value ) mixed with water in a volume ratio of 7:7:8. Put the acid-treated titanium-tantalum composite material in a 5M sodium hydroxide solution, and perform alkali heat tre...

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Abstract

The invention discloses an osteogenesis promoting rubidium-titanium-tantalum-containing composite material, a preparation method thereof and an application of the composite material. According to themethod, sand blasting, acid treatment and alkali heat treatment of a titanium tantalum composite material synthesized by plasma activated sintering are implemented, so that the surface of the titaniumtantalum composite material is modified, rubidium salt penetrates the titanium tantalum composite material with the modified surface through ion exchange, and the material is calcined at high temperature to prepare the osteogenesis promoting rubidium-titanium-tantalum-containing composite material. The composite material has good biocompatibility, does not have cytotoxicity, facilitates cell proliferation and effectively induces pre-osteoblasts to achieve osteoblast differentiation. The material can effectively solve the problems of poor compatibility of bone repairing materials and a human body when the bone repairing materials are clinically applied and the like, and the material has a wide application prospect in clinical bone repairing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application. Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium-tantalum composite materials are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium-tantalum composite materials. material as a bone replacement material. However, since the titanium-tantalum composite material is a biologically inert material, the combination with the hum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/50C22C1/04C22C27/02
CPCA61L27/047A61L27/50A61L2400/18A61L2430/02C22C1/045C22C27/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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