A kind of composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application

A composite material and osteogenesis-promoting technology, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as surgical failure and poor biological activity, and achieve poor biocompatibility, good osteogenesis, and excellent osteogenesis The effect of bone properties

Active Publication Date: 2021-09-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problem in the prior art that the medical titanium-tantalum composite material has poor biological activity and is likely to cause operation failure in actual clinical application, the purpose of the present invention is to provide a bone-promoting rubidium-titanium-tantalum composite material with excellent mechanical properties and biological activity. Materials and their preparation methods and applications

Method used

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  • A kind of composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application
  • A kind of composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application
  • A kind of composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application

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Effect test

Embodiment 1

[0041]Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:30; then put the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering, and the sintering is completed to obtain a titanium-tantalum composite Materials, the sintering procedure is as follows: the heating rate is 70°C / min, the sintering temperature is 1000°C, the sintering time is 5min; the sintering pressure is 60MPa.

[0042] The titanium-tantalum composite material was subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 70°C for 28 hours, wherein the acid solution was composed of hydrochloric acid (mass fraction: 38%), sulfuric acid (mass fraction: 96%) and water in a volume ratio of 7:7:8 mixed to get. Put the acid-treated titanium-tantalum composite material in 4M potassium hydroxide solution, and perform alkali heat treatment at 70°C for 28 hours; then w...

Embodiment 2

[0065] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then put the titanium-tantalum alloy powder in a discharge plasma sintering furnace for sintering, and the sintering is completed to obtain a titanium-tantalum composite Materials, the sintering procedure is as follows: the heating rate is 50°C / min, the sintering temperature is 1300°C, the sintering time is 5min; the sintering pressure is 30MPa.

[0066] The titanium-tantalum composite material is subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution is composed of hydrochloric acid (mass fraction: 37% write specific value), sulfuric acid (mass fraction: 95% write specific value ) mixed with water in a volume ratio of 7:7:8. Put the acid-treated titanium-tantalum composite material in a 5M sodium hydroxide solution, and perform alkali heat tre...

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Abstract

The invention discloses a bone-promoting rubidium-titanium-tantalum composite material and its preparation method and application. The method performs sand blasting, acid treatment and alkali heat treatment on the titanium-tantalum composite material synthesized by plasma activation and sintering to modify the surface of the titanium-tantalum composite material. properties, and the surface of the surface-modified titanium-tantalum composite material is doped with rubidium salt through ion exchange, and finally the bone-promoting rubidium-titanium-tantalum composite material is prepared by high-temperature calcination. The material of the invention has good biocompatibility, does not have cytotoxicity, promotes cell proliferation, and has a good effect of inducing osteogenic differentiation of pre-osteoblasts. The material can effectively solve the problems of poor compatibility with the human body in clinical application of bone repair materials, and has broad application prospects in clinical bone repair.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite material containing rubidium, titanium and tantalum for bone formation and its preparation method and application. Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium-tantalum composite materials are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium-tantalum composite materials. material as a bone replacement material. However, since the titanium-tantalum composite material is a biologically inert material, the combination with the hum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/50C22C1/04C22C27/02
CPCA61L27/047A61L27/50A61L2400/18A61L2430/02C22C1/045C22C27/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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