A kind of injectable PMMA antibiotic bone cement and preparation method thereof

A technology of antibiotics and bone cement, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of volume shrinkage, poor biological activity, high modulus of antibiotic bone cement, etc., achieve efficient and sustained release, increase specific surface area and porosity Effect

Active Publication Date: 2021-08-06
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The object of the present invention is to provide an injectable PMMA antibiotic bone cement, which solves the problems of high modulus, volume shrinkage and poor biological activity of the existing antibiotic bone cement

Method used

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  • A kind of injectable PMMA antibiotic bone cement and preparation method thereof

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preparation example Construction

[0033] A kind of preparation method of injectable PMMA antibiotic bone cement of the present invention specifically comprises the following steps:

[0034] Step 1, preparing CMC-g-PAA copolymer powder;

[0035] The concrete steps of preparing CMC-g-PAA copolymer powder are:

[0036] Step 1.1: Take carboxymethyl cellulose 2.702%~15.151%, acrylic acid 54.054%~60.606%, initiator ammonium persulfate 0.2%~2%, crosslinking agent N,N-methylenebisacrylamide 0.02%~ 0.2% and deionized water 32.432% ~ 36.363%, total 100%. Add carboxymethyl cellulose solution, AA, cross-linking agent MBA solution and initiator APS solution to the four-necked flask in sequence and mix evenly. The obtained mixed solution is continuously stirred and heated to 35°C-55°C, in which the carboxymethyl The preparation methods of the cellulose solution, the initiator ammonium persulfate and the crosslinking agent N,N-methylenebisacrylamide are all dissolved in deionized water at room temperature, supplemented by ...

Embodiment 1

[0045] Step 1, the preparation of CMC-g-PAA copolymer:

[0046] The reaction was carried out in a four-necked flask equipped with a mechanical stirrer, a thermometer, a condensing reflux device and nitrogen gas. Take 6 g of carboxymethyl cellulose, 50 g of acrylic acid, 0.5 g of initiator ammonium persulfate, and crosslinking agent N, respectively. Add 0.05 g of N-methylenebisacrylamide and 30 g of deionized water, add carboxymethyl cellulose solution, AA, cross-linking agent MBA solution and initiator APS solution into a four-necked flask in sequence and heat to 55°C, continuously stirring, use N 2 Purging for 1h to remove dissolved oxygen in the solution, then raising the temperature to 75°C, and reacting at a constant temperature in a nitrogen atmosphere for 4h, the CMC-g-PAA copolymer can be obtained, and the obtained product is washed 20 times with deionized water, and then CMC-g-PAA copolymer powder was obtained by vacuum drying at ℃ for 24 h to constant weight, and fin...

Embodiment 2

[0054] Step 1, the preparation of CMC-g-PAA copolymer:

[0055] The reaction was carried out in a four-necked flask equipped with a mechanical stirrer, a thermometer, a condensing reflux device and nitrogen gas. Take 6 g of carboxymethyl cellulose, 50 g of acrylic acid, 0.05 g of initiator ammonium persulfate, and crosslinking agent N, respectively. 0.005g of N-methylenebisacrylamide and 30g of deionized water, add carboxymethyl cellulose solution, AA, crosslinking agent MBA solution and initiator APS solution into a four-necked flask in sequence and continue to stir and heat to 40°C. use N 2 Purging for 0.5h to remove dissolved oxygen in the solution, then raising the temperature to 70°C, and reacting at a constant temperature in a nitrogen atmosphere for 2h, the CMC-g-PAA copolymer can be obtained, and the obtained product is washed 15 times with deionized water, and then Vacuum-dried at 60° C. for 12 h to constant weight, and finally ground and sieved to obtain CMC-g-PAA c...

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Abstract

The invention discloses an injectable PMMA antibiotic bone cement, which is composed of the following raw materials according to the mass percentage: polymethyl methacrylate 30%-50%, CMC-g-PAA 5%-40%, developer barium sulfate 2.791 %~10.845%, initiator benzoyl peroxide 0.013%~1.3%, antibiotic gentamicin sulfate 0.902%~2.355%, methyl methacrylate monomer 20%~50%, N,N‑dimethyl p-toluidine 0.2%~2%, hydroquinone 0.015%~0.15%, the total is 100%; the invention also discloses the preparation method of the cement; an injectable PMMA antibiotic bone cement of the invention overcomes the existing It has the problems of low drug release rate of antibiotic bone cement, high elastic modulus, volume shrinkage, and poor biological activity, and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injectable PMMA antibiotic bone cement, and also relates to a preparation method of the cement. Background technique [0002] Since Buchholz and Engelbrecht et al first applied penicillin, erythromycin, and gentamicin in bone cement to locally control periprosthetic tissue infection in 1970, people began to recognize the advantages of this local drug delivery system. Methyl acrylate (PMMA) bone cement is constantly updated and widely used clinically. At present, the research results on PMMA antibiotic bone cement are numerous, but there are still some problems. First, the release of antibiotics from the bone cement matrix is ​​mainly determined by the surface roughness and porosity of the bone cement, and the release of antibiotics in most bone cements Mainly concentrated in the dough stage, the drug release is low, and cannot effectively prevent and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/20A61L27/56A61L27/54A61L27/50A61L27/58C08F251/02C08F220/06C08F222/38
CPCA61L27/16A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/406A61L2430/02C08F251/02C08L33/12C08L51/02C08F220/06C08F222/385
Inventor 汤玉斐刘佳欣赵康吴子祥陈玉莹张紫萱
Owner XIAN UNIV OF TECH
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