Bacterial cellulose hydrogel dressing for diabetic wound surface and preparation method thereof

A technology of bacterial cellulose and hydrogel, applied in medical science, bandages, etc., can solve the problem that dressings are not suitable for diabetic wounds, and achieve the effects of reducing blood sugar on wounds, ensuring safety, and promoting healing rates
CN110215536AActive Publication Date: 2019-09-10SHANGHAI JIAO TONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI JIAO TONG UNIV
Publication Date
2019-09-10

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Abstract

The invention provides a bacterial cellulose hydrogel dressing for a diabetic wound surface and a preparation method thereof. The hydrogel dressing comprises carboxylation bacterial cellulose and amination glucose oxidase, and the carboxylation bacterial cellulose and the amination glucose oxidase are in amido bond connection. The hydrogel dressing further comprises plerixafor; the plerixafor is loaded inside the hydrogel dressing. Glucose oxidase is grafted to the surface of the hydrogel dressing through amido bonds, the gluconic effect in the wound surface can be lowered, and glucose oxidasecannot enter blood circulation; meanwhile, the stem cell mobilizing drug AMD3100 is loaded in the modified cellulose dressing through the physical adsorption effect, the medicine can be released intobody fluid when the dressing makes contact with the wound surface, and the drug is used for prompting generation of new vessels at the wound surface.
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Description

technical field

[0001] The present invention relates to the technical field of biomedical materials, in particular, to a bacterial cellulose hydrogel dressing for diabetic wounds and a preparation method thereof. The present invention provides a novel bacterial cellulose wound dressing and its application in diabetic wound healing Applications. Background technique

[0002] Diabetic wound ulcer is a common complication of diabetes, which is common in the feet of diabetic patients. Due to high blood sugar levels, wounds in diabetics heal at a much slower rate than healthy people. The healing process of wounds is divided into four stages: coagulation period, inflammation period, proliferation period and remodeling period. However, blood vessels and nerves in diabetic wounds have lesions, resulting in slow or impossible regeneration of blood vessels and nerves in the wound proliferation period, which is the cause of The main reason for the slow healing rate of diabetic wounds...

Claims

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