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A rapid analysis method for phosphorus-32 in urine samples

A rapid analysis and urine sample technology, applied in the direction of radiation measurement, instruments, measuring devices, etc., can solve the problems of complex and time-consuming calibration of chemical recovery rate, detection efficiency, and P-32 can not meet the time requirements, and achieve accurate analysis. Effect

Active Publication Date: 2022-05-20
CHINA INST FOR RADIATION PROTECTION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the above analysis methods for P-32 in urine samples can meet the needs of routine P-32 analysis, the correction of chemical recovery rate and P-32 detection efficiency of samples is complicated and time-consuming, so it is used for rapid screening and rapid assessment of emergency accidents P-32 in the urine sample below cannot meet the time limit requirement

Method used

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  • A rapid analysis method for phosphorus-32 in urine samples
  • A rapid analysis method for phosphorus-32 in urine samples
  • A rapid analysis method for phosphorus-32 in urine samples

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: The Cerenkov detection efficiency of P-32 and the relationship curve determination of TDCR value

[0045] The TDCR (Triple to double coincidence ratio) measuring device is equipped with three photomultiplier tubes, and the sample can be double counted and triple counted during the measurement process. The TDCR value is the ratio of the triple count to the double count. The calculation formula is shown in the formula (1 ).

[0046]

[0047] in:

[0048] T ripS Triple count for samples;

[0049] T ripB is the blank triple count, that is, the background triple count;

[0050] D. oubS Double count for samples;

[0051] D. oubB It is the double count of the blank, that is, the double count of the background.

[0052] Based on the TDCR measurement technology of this device, the detection efficiency of the sample is corrected by the TDCR value, and the entire calibration process does not involve external radioactive sources, so this technology is an ab...

Embodiment 2

[0062] Example 2: CH under heating conditions 3 Study on Inhibitory Effect of COOH on Chemiluminescence of Urine Samples

[0063] Urine samples are usually light yellow to brown, which can cause strong color quenching, which greatly reduces the detection efficiency of Cerenkov. In severe cases, the detection efficiency of Cerenkov will be lower than 10%. Under acidic conditions, adding H 2 o 2 It can decompose the colored substances in the urine sample and make the urine sample clear, so that the detection efficiency of Cerenkov can be significantly improved by nearly 40%. But adding H 2 o 2 The problem is that H 2 o 2 The residues will cause chemiluminescence in the urine sample, resulting in higher analysis results. Due to heating and long-term storage conditions, H 2 o 2 It is unstable and easy to decompose, so the urine sample can be left for a long time (usually more than 10 hours) until the chemiluminescence decays to a low enough level before measurement. Due ...

Embodiment 3

[0071] Example 3: Comparative study of P-32 measured value and expected value of spiked sample

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Abstract

The invention belongs to the technical field of radionuclide detection and relates to a rapid analysis method for phosphorus-32 in urine samples. Described analytical method comprises the following steps: (1) in water or aqueous solution, successively add the pigment of different concentrations and P-32 radioactive standard substance, after directly measuring sample double and triple count successively, calculate the TDCR value and detection efficiency of sample , and fitting the relationship curve between them; (2) adding HCl and H 2 o 2 Carry out heat treatment; (3) after heat treatment finishes, add CH in urine sample 3 COOH, measure the double and triple counts of the sample after cooling to room temperature; (4) According to the relationship curve established in step (1), the detection efficiency of the sample is calculated by the TDCR value of the sample obtained in step (3), after detection efficiency correction Obtain the activity of P-32 in the sample. Utilizing the analysis method of the present invention, the phosphorus-32 in the urine sample can be quickly and accurately analyzed without correction of the chemical recovery rate.

Description

technical field [0001] The invention belongs to the technical field of radionuclide detection and relates to a rapid analysis method for phosphorus-32 in urine samples. Background technique [0002] P-32 is a short-lived high-energy β nuclide (half-life 14.262 days, E max =1.709MeV), belongs to artificial radionuclide. Because phosphorus can exist in biological tissues in various forms, P-32 has a wide range of applications, including medicine, radiochemistry, molecular biology and agriculture. [0003] Phosphorus-32 is one of the earliest radionuclides used clinically. For example, sodium phosphate [P-32] injection can be used to treat polycythemia vera, essential thrombocythemia and other diseases; colloidal chromium phosphate [P-32] injection can be used for the treatment of cancerous pleural effusion and Used as adjuvant therapy for certain malignant tumors. However, before discharge from the hospital, the P-32 activity in urine samples should be monitored to prevent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01T1/167
CPCG01T1/167
Inventor 马彦杨永刚戴雄新
Owner CHINA INST FOR RADIATION PROTECTION