Medicine composition for treating cold symptoms such as running noses and nasal obstruction and preparation method and application of medicine composition

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, drug delivery, etc., can solve problems such as toxic side effects, adverse health, and damage to children's health, and achieve stable blood drug concentration, good therapeutic effect, and low toxic and side effects Effect

Active Publication Date: 2019-09-27
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking cold medicine indiscriminately will not cure the cold, but it will be bad for your health
Many parents halve the adult cold medicine for their children, which will damage children's health and cause damage to liver and kidney function, n

Method used

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  • Medicine composition for treating cold symptoms such as running noses and nasal obstruction and preparation method and application of medicine composition
  • Medicine composition for treating cold symptoms such as running noses and nasal obstruction and preparation method and application of medicine composition
  • Medicine composition for treating cold symptoms such as running noses and nasal obstruction and preparation method and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1 (taking preparation 1000ml as example)

[0052] prescription:

[0053]

[0054] Preparation:

[0055] 1. Weigh the prescribed amount of glycerin and polyethylene glycol 4000, put them in a certain container, stir and mix to obtain solution a;

[0056] 2. Take the above solution a, add the prescribed amount of sorbic acid, stir, and disperse to obtain solution b;

[0057] 3. Sequentially weigh disodium ethylenediaminetetraacetic acid, anhydrous citric acid, sodium saccharin, allura red, brilliant blue, and grape essence in the prescribed amount, and add them into solution b to obtain solution c;

[0058] 4. Measure a small amount of purified water, add it to solution c, stir, fully dissolve to obtain a transparent and uniform solution, and obtain solution d;

[0059] 5. Finally, add the prescription amount of brompheniramine maleate, phenylephrine hydrochloride, and dextromethorphan hydrobromide to the solution d in turn, stir, add water to 1000ml, stir ...

Embodiment 2

[0060] Embodiment 2 (taking preparation 1000ml as example)

[0061] prescription:

[0062] name Prescription amount name Prescription amount brompheniramine maleate 0.30g sodium saccharin 1.50g Dextromethorphan Hydrobromide 1.00g Hexametaphosphate 0.25g Phenylephrine Hydrochloride 0.50g Anhydrous citric acid 4.00g Propylene Glycol 120.00g allura red 12.00mg polyethylene glycol 4000 120.00g Bright blue 4,10mg Sorbitol 230.00g grape essence 3ml Ethylparaben 0.75g Add purified water to 1000ml

[0063] Preparation:

[0064] 1. Weigh the prescribed amount of propylene glycol and polyethylene glycol 4000, put them in a certain container, stir and mix to obtain solution a;

[0065] 2. Take the above solution 1, add the prescribed amount of sorbitol, stir, and disperse to obtain solution b;

[0066] 3. Add a small amount of prescribed amount of water to solution b, heat in a water bath at 60°C for 15 ...

Embodiment 3

[0069] Embodiment 3 (taking preparation 1000ml as example) (preferred)

[0070] name Prescription amount name Prescription amount brompheniramine maleate 0.20g sodium benzoate 1.04g Dextromethorphan Hydrobromide 1.00g sodium saccharin 1.80g Phenylephrine Hydrochloride 0.50g Edetate disodium 0.35g glycerin 123.0g Anhydrous citric acid 5.72g Propylene Glycol 120.0g allura red 14.0mg Sorbitol 377.0g Bright blue 5.30mg grape essence 4.0ml Add purified water to 1000ml

[0071] Preparation:

[0072] 1. Weigh the glycerin and propylene glycol of the above prescription amount, put them in a certain container, stir and mix well, and obtain solution a;

[0073] 2. Take the above solution a, add the prescribed amount of sorbitol, stir, and disperse to obtain solution b;

[0074] 3. Sequentially weigh the prescribed quantities of edetate disodium, anhydrous citric acid, sodium benzoate, sodium saccharin, a...

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PUM

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Abstract

The invention discloses a medicine composition for treating cold symptoms such as running noses and nasal obstruction and a preparation method and application of the medicine composition. The medicine composition is an oral liquid preparation consisting of brompheniramine maleate, dextromethorphan hydrobromide, phenylephrine hydrochloride as well as certain amounts of auxiliary materials such as a cosolvent, a preservative, a complexing agent, a pH value adjusting agent, a flavoring agent and an aromatic. The medicine composition has functions of alleviating and treating nasal obstruction caused by cold, cough, sore throats, headache, slight ache and pain and fever caused by slight irritation of throats and bronchi, and the like. The invention provides a cold medicine for children of 6-12 years old and adults and children greater than 12 years old.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology research and development, and in particular relates to a pharmaceutical composition for treating cold symptoms such as runny nose and nasal congestion, as well as its preparation method and application. Background technique [0002] A cold is a common respiratory disease that can occur in all seasons. It is caused by a variety of viruses or bacteria. It has symptoms such as runny nose, chest tightness, cough, sneezing, headache, fever or cough. If not treated in time, it can cause Many complications, such as pneumonia, myocarditis, etc., bring serious harm to people's health. Drug active substances commonly used to treat the above symptoms include antihistamines, antitussives, expectorants, demulcents, anesthetics, analgesics, antipyretics, and anti-inflammatory drugs. The active ingredients of these drugs are mostly norepinephrine, pseudoephedrine, guaifenesin, chlorpheniramine, diphenhy...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K31/137A61K31/4402A61K9/08A61K47/10A61P11/00A61P11/02
CPCA61K31/137A61K31/485A61K31/4402A61K9/08A61K47/10A61P11/00A61P11/02A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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