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A kind of preparation method of concentrated water pills for traditional Chinese medicine prescription preparation

A technology for concentrated water and preparations, applied in the field of medicine, can solve the problems that cannot meet the requirements of rapid preparation, low consumption, high drug loading, high drug yield, easy operation, easy learning and mastery, high production efficiency, and prolonging the preparation molding process and development cycle. , violating the single dose of concentrated pills, etc., to achieve the effect of shortening the preparation cycle, easy to learn and master, and fewer factors to investigate

Active Publication Date: 2021-11-26
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After mixing the medicinal powder and the extract prepared according to the above general principles, it often occurs that the pellets cannot be bonded and formed due to too low viscosity, or the pellets are easily bonded due to excessive viscosity, resulting in large loss and poor forming degree. Usually, it is necessary to add binders such as water, ethanol, alcohol water, honey, or excipients such as starch and sugar, which undoubtedly complicates the preparation molding process, reduces controllability, prolongs the preparation molding process and development cycle, and violates the The original intention of reducing the single dose of concentrated pills cannot meet the requirements of fast, low loss, high drug loading, high drug yield, easy operation, easy learning and mastering, and high production efficiency of clinical preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] prescription:

[0022] Dried ginger 80g, skullcap 80g, jujube 80g, coptis 24g, codonopsis 80g, licorice 80g, citrus aurantium 80g, red peony 80g, ginger pinellia 80g (total prescription weight: 664g).

[0023] Process:

[0024] 1, pulverize: screen the medicinal material (dry ginger 80g, Radix Paeoniae Rubra 40g, Fructus Aurantii Fructus 80g, Radix Glycyrrhizae 40g) of total prescription 36% weight ratio according to the powder sieving rate of the single medicinal material from high to low and pulverize, cross No. 5 sieve, 217.02 g of powder was obtained.

[0025] 2. Decoction: decoct the remaining coarse powder and the remaining medicinal materials (decoction twice, add 8 times the amount of water, 1 hour each time), combine the medicinal liquid, filter, concentrate, and concentrate to 1.7pa.s (100°C) .

[0026] 3. Pill making: Mix the concentrated solution with the above powder to make a soft material, extrude in an extrusion spheronizer and roll into a ball to obt...

Embodiment 2

[0029] prescription:

[0030] 60g lotus leaf, 60g cassia seed, 60g raw coix seed, 60g red bean, 60g prunella vulgaris, 60g seaweed, 6g leech, 30g hawthorn, 30g citrus aurantium, 12g raw rhubarb, 20g peach kernel, 30g white mustard seed, 20g tangerine peel, 20g pinellia , Poria cocos 30g, coptis 12g, cinnamon 2g, gypsum 60g, Alisma 30g (total prescription weight: 662g).

[0031] Process:

[0032] 1. Pulverization: according to the powder sieve rate of the single medicinal material from high to low, the medicinal materials (Poria cocos 30g, Alisma 30g, raw coix seed 60g, red bean 60g, Citrus aurantium 20) of the total prescription 30% weight ratio are pulverized. No. 5 sieve to obtain 178.19g of powder.

[0033] 2. Decoction: decoct the remaining coarse powder, the remaining coarse powder and the remaining medicinal materials (decoction twice, add 8 times the amount of water, 1 hour each time), combine the medicinal liquid, filter, concentrate, and concentrate to 3.2pa.s (100...

Embodiment 3

[0037] prescription:

[0038] Amomum 100g, Ganoderma lucidum 140g, Ginseng 60g, Asparagus 150g, Ophiopogon japonicus 150g, Bran fried Atractylodes 150g, Poria cocos 225g, Rehmannia 200g (total prescription weight: 1175g).

[0039] Process:

[0040]1, pulverize: screen the medicinal material (Ginseng 60g, Poria cocos 225g, Amomum 45g) of total prescription 28% weight ratio according to the powder sieve rate of the single medicinal material from high to low and pulverize, pass No. 5 sieves, get powder 302.32g.

[0041] 2. Decoction: decoct the remaining coarse powder and the remaining medicinal materials (decoction twice, add 8 times the amount of water, 1 hour each time), combine the medicinal liquid, filter, concentrate, and concentrate to 2.9pa.s (100°C) .

[0042] 3. Pill making: Mix the concentrated solution with the above powder to make a soft material, extrude in an extrusion spheronizer and roll into a ball to obtain a wet pellet, and dry it in an oven (60°C, 2h).

[...

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PUM

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Abstract

The invention belongs to the field of medicine, and in particular relates to a method for preparing concentrated water pills used in traditional Chinese medicine prescription preparations. The medicinal material powder passed through the No. 5 sieve; the remaining medicinal materials in the prescription are extracted and concentrated to a suitable viscosity to obtain a concentrated solution; the medicinal material powder passed through the No. 5 sieve is mixed with the concentrated solution to make soft materials and pellets. The preparation method of the concentrated water pill of the present invention uses both medicines and supplements, does not need to add preparation auxiliary materials outside the prescription, is suitable for most traditional Chinese medicine compound prescriptions, and has the advantages of high efficiency, high drug loading, and easy learning.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a method for preparing concentrated water pills used in traditional Chinese medicine prescription preparations. Background technique [0002] Prescription preparations refer to the fact that doctors prescribe prescriptions based on the needs of individual patients for syndrome differentiation and drug performance, and put forward temporary deployment requirements, and then the personnel in charge of dispensing process them into different dosage forms for patients with relevant processes. It is an important aspect of personalized pharmaceutical services. content. Many people often agree that traditional Chinese medicine has good efficacy, but in the process of taking medicine, they are unwilling to decoct it to save trouble, or because of the bad taste of the soup, they often give up using Chinese medicine. This phenomenon of "approving traditional Chinese medicine but rejecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/9068
CPCA61K9/20A61K36/344A61K36/484A61K36/539A61K36/65A61K36/71A61K36/718A61K36/725A61K36/752A61K36/8888A61K36/9068A61K2236/331A61K2236/39A61K2300/00
Inventor 洪燕龙胡志强张磊林晓沈岚鲜洁晨
Owner SHANGHAI UNIV OF T C M
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