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Antibacterial and degradable magnesium alloy nail and manufacturing method thereof

A manufacturing method, magnesium alloy technology, applied in medical science, surgery, etc., can solve problems such as bacterial infection of bone nail implant materials, achieve the effects of reducing the frequency of cell or tissue infection, improving antibacterial properties, and promoting recovery

Inactive Publication Date: 2019-10-08
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical task of the present invention is to provide an antibacterial and degradable magnesium alloy bone nail and its manufacturing method in view of the problem that the current bone nail implant material is easy to cause bacterial infection

Method used

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  • Antibacterial and degradable magnesium alloy nail and manufacturing method thereof
  • Antibacterial and degradable magnesium alloy nail and manufacturing method thereof
  • Antibacterial and degradable magnesium alloy nail and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An antibacterial and degradable magnesium alloy bone nail. In terms of mass fraction, the bone nail includes the following components: Cu: 0.08%, Ag: 0.08%, Sr: 1.0%, Ta: 0.05%, Ca: 0.4%, The content of a single impurity is less than 0.05%, the total amount of impurities is not more than 0.3%, and the balance is Mg.

[0037] Based on the bone nail of above-mentioned components, its manufacture method step is as follows:

[0038](1) Calculate and prepare the raw materials required for bone nails. The raw materials are high-purity magnesium ingots, high-purity silver wires, high-purity copper wires, Mg-Sr, Mg-Ta, and Mg-Ca master alloys; the mass fraction of magnesium in the high-purity magnesium ingots is ≥99.99% %, the mass fraction of silver in the high-purity silver wire is ≥99.99%, the mass fraction of copper in the high-purity copper wire is ≥99.99%; the mass fraction of Sr in the Mg-Sr master alloy is 10%, and the Ta in the Mg-Ta master alloy The mass fraction of ...

Embodiment 2

[0042] An antibacterial and degradable magnesium alloy bone nail. In terms of mass fraction, the bone nail includes the following components: Cu: 0.1%, Ag: 0.1%, Sr: 1.5%, Ta: 0.06%, Ca: 0.4%, The content of a single impurity is less than 0.05%, the total amount of impurities is not more than 0.3%, and the balance is Mg.

[0043] The manufacturing method of the bone nail based on the above components is the same as in Example 1.

Embodiment 3

[0045] An antibacterial and degradable magnesium alloy bone nail. In terms of mass fraction, the bone nail includes the following components: Cu: 0.2%, Ag: 0.2%, Sr: 2.0%, Ta: 0.07%, Ca: 0.6%, The content of a single impurity is less than 0.05%, the total amount of impurities is not more than 0.3%, and the balance is Mg.

[0046] The manufacturing method of the bone nail based on the above components is the same as in Example 1.

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Abstract

The invention provides an antibacterial and degradable magnesium alloy nail and a manufacturing method thereof. The nail is prepared from the following components: 0.05~0.5% of Cu, 0.05~0.5% of Ag, 1.0~3.0% of Sr, 0.05~0.1% of Ta, and 0.4~0.8% of Ca, the content of each single impurity of inevitable Fe, Zn and Al is less than 0.05%, the total amount of the impurities is no more than 0.3%, and thebalance is Mg, the nail can generate microscale Ag+ and Cu2+ in an implanation cycle, under the environment of the Ag+ and Cu2+, probability of bacterial infection in an implanation part is significantly reduced, produced Sr2+ can participate calcification of bones, functions that formation of osteoblast is promoted and bone resorption of osteoclast is inhibited are provided, and development of skeletons and formation of osteoid are promoted, after Sr and Ta alloying, materials have chemical stability and physiological corrosion resistance, and degradation products have good biocompatibility,at the same time, according to the magnesium alloy nail, the structural design is novel, a process of the manufacturing method is simple, operation is convenient, and popularization is facilitated.

Description

technical field [0001] The invention relates to the field of metal medical implant materials, in particular to an antibacterial and degradable magnesium alloy bone nail and a manufacturing method thereof. Background technique [0002] Magnesium alloys have become a new generation of medical biomaterials due to their excellent properties such as low density, high specific strength, good processability and biocompatibility, and are favored by biomaterial researchers and medical personnel. Compared with traditional medical metal materials and degradable polymer materials, magnesium alloy has the following outstanding advantages as a medical implant material: [0003] (1) Good biocompatibility [0004] Magnesium is an essential mineral for human metabolism and an indispensable element for the nervous system. Many cases are related to its deficiency. Magnesium is second only to calcium and phosphorus in the mineral content of the human body, and its content is second only to po...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/14A61L31/16
CPCA61L31/022A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/104A61L2300/404A61L2300/412
Inventor 铁镝颜路飞任浩博张博彧管仁国刘立忠
Owner NORTHEASTERN UNIV
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