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Preparation method of industrial hemp extract

A technology of industrial hemp and extracts, applied in the preparation of organic compounds, chemical instruments and methods, medical preparations containing active ingredients, etc., can solve problems such as toxicity, harm to experimenters and the environment, and cumbersome processes, and achieve reagent Environmental protection, easy access to equipment and simple process operation

Active Publication Date: 2019-10-15
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent applications CN106860492A and CN109568389A disclose extraction and preparation methods of cannabinoids, but the process is cumbersome, and the reagents used are Class II reagents, which are toxic to a certain extent and will cause harm to experimenters and the environment

Method used

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  • Preparation method of industrial hemp extract
  • Preparation method of industrial hemp extract
  • Preparation method of industrial hemp extract

Examples

Experimental program
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Effect test

preparation example Construction

[0076] Preparation of the reference substance solution: Accurately weigh the CBD reference substance, add methanol to make a 0.15mg / mL reference substance solution; Accurately weigh the THCV reference substance, add methanol to make a 0.01mg / mL reference substance solution, and get it; accurately weigh the CBG reference substance, add methanol to make a 0.01mg / mL reference substance solution, and get it; Take tetrahydrocannabinol reference substance, add methanol to make 0.01mg / mL reference substance solution, and obtain it.

[0077] Preparation of the test solution: Take 1.1mL of the sample solution, add methanol to make it up to 25mL, filter it with a microporous membrane (0.45μm), and take the subsequent filtrate to obtain the final product.

[0078] Determination method: Precisely draw 10 μL each of the reference substance solution and the test solution, inject it into the liquid chromatograph, measure it, and obtain it.

[0079] figure 1 Shown is the blank control (95% ...

Embodiment 1

[0081] (1) Grind the flower and leaves of industrial hemp, pass through a No. 1 sieve, bake at 100°C for 200 minutes, take a certain amount of the flowers and leaves of hemp after roasting, and add 95% of the hemp flowers and leaves according to the material-to-liquid ratio of 1:8 (w / v) Ethanol, stirring and extracting at room temperature twice, each time for 1 hour, filtering, combining the extracts, centrifuging, concentrating the centrifuged filtrate under reduced pressure (65°C, -0.08~-0.09Mpa) to the extract, adding 3 times the equivalent of medicinal materials for purification water, keep stirring at 75°C for 30 minutes, put it in a liquid separation tank and cool to room temperature, add sodium carbonate and stir to dissolve, leave it at room temperature for 3 hours, separate the upper layer, and obtain the crude cannabis extract.

[0082] (2) Stir and dissolve the obtained cannabis crude extract with 95% ethanol of 3 times the equivalent of the medicinal materials, add ...

Embodiment 2

[0084] (1) Grind the flower and leaves of industrial hemp, pass through a No. 3 sieve, bake at 200°C for 60 minutes, take a certain amount of the flowers and leaves of hemp after roasting, and add 90% according to the ratio of material to liquid: 1:10 (w / v) Ethanol, stirred at room temperature and extracted twice, each time for 1 hour, filtered, combined extracts, centrifuged, concentrated the centrifuged filtrate under reduced pressure (65°C, -0.08~-0.09Mpa) to the extract, added 2 times the equivalent of medicinal materials for purification Water, heat preservation and rotation at 70°C for 30 minutes, perform butterfly centrifugation and layering of the transsolution solution at a speed of 5000 rpm, separate the upper layer, and obtain the crude cannabis extract.

[0085] (2) Stir and dissolve the obtained cannabis crude extract with 95% ethanol which is 3 times the equivalent of the medicinal material, add 0.05 times the diatomite equivalent of the medicinal material, stir a...

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Abstract

The invention discloses a preparation method of an industrial hemp extract. A cannabinol compound is enriched by salting and centrifugation, and water-soluble impurities can be completely removed in one step, thereby avoiding solvent residues such as toluene, xylene and the like introduced when the water-soluble impurities are removed by applying a conventional water-sinking process or macroporousresin, and greatly saving the production cost and the quality control cost; and a psychoactive ingredient THC can be completely excluded. In the above method, only pure water and three kinds of organic reagents with low toxicity are used, therefore, the reagents are environmentally-friendly, the process operation is simple, the instruments and equipment are readily available, the cost can be reduced, the pollution is reduced, and the industrial production is facilitated. The industrial hemp extract obtained by the above method is rich in the cannabinol compounds such as CBDV, CBG, CBD and thelike; the total content of the above cannabinoid compounds can be up to 80 percent or above, and the transfer rate can be up to 99 percent or above.

Description

technical field [0001] The invention relates to the technical field of extraction, in particular to a preparation method of an industrial hemp extract rich in cannabinoid compounds. Background technique [0002] Cannabis (scientific name: Cannabis sativa L.) is a plant of the Cannabis family and the genus Cannabis, commonly known as hemp, thread hemp, and hemp. It has a long history of cultivation and has important agricultural and medicinal values. It is mainly distributed in Yunnan, Guizhou, Sichuan, and Guangxi. , Anhui and other places, it was mainly used to make clothing, papermaking materials, ropes and oils in ancient times. Marijuana contains a toxic component, tetrahydrocannabinol (THC), which can make people hallucinogenic and addictive. It is easily used by criminals to refine drugs and endanger society. It has been banned by many countries for a long time. [0003] Due to the high economic and medicinal value of cannabis, in the 1980s, some European countries re...

Claims

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Application Information

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IPC IPC(8): C07C37/70C07C37/72C07C37/82C07C39/23C07C39/19C07D311/80A61K36/60A61K36/185A61K8/34A61K8/49A61K31/05A61K31/352A61P19/02A61P25/22A61P25/08A61P3/10A61P3/06A61P29/00A61P1/00A61P1/08A61P13/06
CPCC07C37/004C07D311/80A61K8/347A61K8/498A61K36/60A61K36/185A61K31/05A61K31/352A61P19/02A61P25/22A61P25/08A61P3/10A61P3/06A61P29/00A61P1/00A61P1/08A61P13/06C07C2601/16A61K2800/10C07C39/23C07C39/19
Inventor 谭昕王曙宾孙武兴邢俊波马燕珠范德凯张景
Owner HANYI BIO TECH CO LTD
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