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3D printing perphenazine oral disintegrating tablet and preparation method thereof

A 3D printing, orally disintegrating tablet technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problem of not meeting the urgent needs of patients for medication, and the long disintegration time of perphenazine orally disintegrating tablets, etc. problems, to achieve the effect of improving compliance, reducing drug toxicity and side effects, and solving disintegrating tablets

Inactive Publication Date: 2019-10-22
互竑实业(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disintegration time of perphenazine oral powder on the market is long, and it cannot meet the urgent needs of patients for medication

Method used

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  • 3D printing perphenazine oral disintegrating tablet and preparation method thereof
  • 3D printing perphenazine oral disintegrating tablet and preparation method thereof
  • 3D printing perphenazine oral disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The prescription is as follows:

[0029]

[0030] 3D printing parameters are as follows:

[0031]

[0032] The preparation method is as follows:

[0033] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0034] (2) Calculated by mass percentage, mix perphenazine (10%), sucrose (86%), and micropowdered silica gel (1.0%) evenly in proportion, and put them into the powder box of the 3D printing rapid prototyping machine as a drug powder;

[0035] (3) Put 75% ethanol solution into the cartridge;

[0036] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print perphenazine oral disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.20mm on the powder bed, and then prints the selected area of ​​the nozzle in the X-Y axis direction ...

Embodiment 2

[0041] The prescription is as follows:

[0042]

[0043] 3D printing parameters are as follows:

[0044]

[0045] The preparation method is as follows:

[0046] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0047] (2) Calculated by mass percentage, perphenazine (12%), sucrose (52%), pregelatinized starch (29%), povidone K30 (5%), micronized silica gel (1%), stevioside (1%) Mix evenly in proportion, and put it into the powder box of the 3D printing rapid prototyping machine as a powder;

[0048] (3) Put 1% povidone K30-25% ethanol solution into the cartridge;

[0049] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print perphenazine oral disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.40mm on the powder bed, and then pr...

Embodiment 3

[0054] The prescription is as follows:

[0055]

[0056] 3D printing parameters are as follows:

[0057]

[0058] The preparation method is as follows:

[0059] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0060] (2) Calculated by mass percentage, mix perphenazine (9%), mannitol (81%), sodium carboxymethylcellulose (8%), and aspartame (2%) evenly in proportion as a medicinal powder Load it into the powder box of the 3D printing rapid prototyping machine;

[0061] (3) Put 50% ethanol solution into the cartridge;

[0062] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print perphenazine oral disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.25mm on the powder bed, and then prints the selected area of ​​the nozzle in the X...

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Abstract

The invention provides a 3D printing perphenazine oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet is formed by spraying an adhesive liquid by a 3D printer nozzle to make a drug powder adhered and formed. According to preset parameters, a model is built and imported into a control system of a 3D printing rapid forming machine; a powder prepared bymixing evenly 2-12% of perphenazine, 78-95% of a filling agent, 5-13% of a dry adhesive, 0.1-1.0% of micropowder silica gel and 0-2% of a flavoring agent according to the mass percentage in proportion is put into a powder box; the adhesive liquid is put into an ink cartridge; the control system outputs a command, the perphenazine oral disintegrating tablet is printed, after the oral disintegrating tablet is adhered and taken out, the surrounding excess powder is removed, and the product is obtained after drying. The prepared perphenazine oral disintegrating tablet has the advantages of fast disintegration speed, and improvement of the compliance of patients taking drugs, and is particularly convenient for the elderly, children and people with dysphagia.

Description

technical field [0001] The invention belongs to the technical field of drug design, in particular to a 3D printed perphenazine orally disintegrating tablet and a preparation method thereof. Background technique [0002] Three-dimensional printing technology (three dimension printing, 3DP) is a rapid prototyping technology based on digital models. The core idea of ​​3D printing first originated in the United States at the end of the 19th century, and it was not until the late 1980s that it was developed by the Massachusetts Institute of Technology. 3D printing technology is to design and construct a three-dimensional model on computer software based on the CAD model or CT data of the object. It can quickly and accurately manufacture objects with special shapes or complex internal structures. [0003] 3D printing technology was initially used in the fields of manufacturing, aerospace and industrial design. With the development and maturity of 3D printing technology, this eme...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K31/5415A61P25/18
CPCA61K9/0056A61K9/2009A61K9/209A61K9/2095A61K31/5415A61P25/18
Inventor 郑易
Owner 互竑实业(上海)有限公司
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