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Preparation method and uses of 4,6-bis(pyridine-2-yl)pyrimidine-2-amine copper coordination compound

A technology of copper complex and pyridine, which is applied in the field of preparation of 4,6-dipyrimidin-2-amine copper complex, can solve the problems that the catalyst cannot be recycled and cannot be reacted at room temperature, etc. Beneficial for industrial production and easy separation

Active Publication Date: 2019-10-22
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of this invention is to solve the problems that the catalyst cannot be recycled and cannot react at room temperature in the catalytic Mannich reaction of weak acid, alkali or transition metal salt

Method used

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  • Preparation method and uses of 4,6-bis(pyridine-2-yl)pyrimidine-2-amine copper coordination compound
  • Preparation method and uses of 4,6-bis(pyridine-2-yl)pyrimidine-2-amine copper coordination compound
  • Preparation method and uses of 4,6-bis(pyridine-2-yl)pyrimidine-2-amine copper coordination compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: compound [(CuCl 2 ) 2 (C 14 h 11 N 5 )(DMSO) 2 ] · Preparation of 2DMSO

[0025] Add the organic ligand 4,6-bis(pyridin-2-yl)pyrimidin-2-amine (0.1mmol) and 70mmol DMSO sequentially into a clean beaker, stir electromagnetically at room temperature for 30min, CuCl 2 2H 2 O (0.2mmol), electromagnetic stirring for 5 hours, after the reaction was completed, filtered, and the filtrate was allowed to evaporate slowly at room temperature, and massive crystals were obtained in about a week. Yield about 57%.

Embodiment 2

[0026] Embodiment 2: compound [(CuCl 2 ) 2 (C 14 h 11 N 5 )(DMSO) 2 ] · Preparation of 2DMSO

[0027] Add the organic ligand 4,6-bis(pyridin-2-yl)pyrimidin-2-amine (0.2mmol) and 140mmol DMSO in sequence in a clean beaker, stir electromagnetically at room temperature for 30min, CuCl 2 2H 2 O (0.3mmol), electromagnetic stirring for 4 hours, after the reaction was completed, filtered, and the filtrate was left to stand at room temperature to evaporate slowly, and massive crystals were obtained in about a week. The yield is about 50%.

Embodiment 3

[0028] Embodiment 3: compound [(CuCl 2 ) 2 (C 14 h 11 N 5 )(DMSO) 2 ] · Preparation of 2DMSO

[0029] In a clean beaker, add the organic ligand 4,6-di(pyridin-2-yl)pyrimidin-2-amine (0.3mmol), 200mmol DMSO in sequence, stir electromagnetically at room temperature for 20min, CuCl 2 2H 2 O (0.2mmol), electromagnetic stirring for 3 hours, after the reaction was completed, filtered, the filtrate was left to stand at room temperature and evaporated slowly, and massive crystals were obtained in about a week. The yield is about 40%.

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Abstract

The invention discloses a 4,6-bis(pyridine-2-yl)pyrimidine-2-amine copper coordination compound preparation method, which comprises: placing copper chloride, 4,6-di(pyridine-2-yl)pyrimidine-2-amine and dimethyl sulfoxide in a beaker, carrying out a reaction, filtering after the reaction is completed, standing the filtrate, and slowly volatilizing to obtain the copper coordination compound catalyst. According to the present invention, the method has characteristics of rapid reaction, simple reaction process, high product purity, simple post-treatment and the like, has high conversion rate in the Mannich reaction for catalytically substituting phenylacetylene, formaldehyde and hexahydropyridine, and has selectivity of up to 100%.

Description

technical field [0001] The invention belongs to the technical field of catalyst material preparation, and relates to a preparation method and application of a 4,6-bis(pyridin-2-yl)pyrimidin-2-amine copper complex. [0002] technical background [0003] Metal copper salts and their complexes have attracted much attention in the fields of inorganic coordination chemistry, organic synthesis, catalytic reactions, and material chemistry due to their good redox properties, low cost and easy availability, and structural diversity. In recent years, the research on the supramolecular structure of copper coordination compounds has developed rapidly, not only because of the ever-changing structure types, but more importantly, these substances have potential applications in the fields of light, electricity, magnetochemistry, separation, adsorption, and catalysis. prospect. [0004] Mannich reaction occupies a very important position in organic synthesis and industrial production. The re...

Claims

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Application Information

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IPC IPC(8): C07F1/08B01J31/22C07D295/03C07D295/096
CPCB01J31/1815B01J2531/16C07B2200/13C07D295/03C07D295/096C07F1/005
Inventor 李来祥赵雯丽林杰赫庆鹏薛泽春
Owner LIAOCHENG UNIV
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