Method for modifying surface amino group of polymer, and method for characterizing surface related properties of polymer

Abstract

The invention relates to a method for modifying the surface amino group of a polymer, and a method for characterizing the surface related properties of the polymer. The method comprises the followingsteps: carrying out surface hydroxylation treatment on a polymer substrate, immersing the treated polymer substrate in an amino modification solution to self-assembling the surface of the polymer substrate, taking out, washing and blow-drying the self-assembled polymer substrate, and performing baking for completing curing, wherein the amino modification solution is a compounded solution of a silane coupling agent and an anhydrous polyol. The polyol solvent with an excellent viscosity and the aminosilane coupling agent in the modification solution are compounded to effectively adjust the diffusion kinetics of aminosilane molecules in a solvent and reduce the self-assembling rate of the aminosilane molecules on the surface of the polymer substrate, so a film formed after the self-assemblingof the aminosilane molecules on the surface of the polymer substrate has a uniform thickness, sufficient amino functional active sites and a high repeatability, and provides a necessary premise for the subsequent polymer substrate to provide a good-repeatability and high-throughput fixing platform for biosensors and bioassay analysis platforms.

Description

technical field [0001] The invention belongs to the field of nanometer materials, relates to a self-assembly method, in particular to a method for regulating and controlling the modification of amino groups on the surface of a polymer substrate. Background technique [0002] With the rapid development of today's high technology, people have been able to integrate various complex micro-nano structures on the surface of substrates of various materials, and then carry out specific functional modifications on the micro-nano structures on the substrate surface to realize the Features of functional applications. For example, in the field of microfluidic chip application technology that has developed rapidly in recent years, scientists first construct a micron-scale fluid channel structure on the surface of the substrate, that is, a microchannel. Through the design of the microchannel structure and the physical and chemical properties of the microchannel surface It realizes a high...

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Problems solved by technology

However, these two methods all have a common difficulty: the hydrolysis rate of APTES molecules on the substrate surface is very fast, and a large amount of APTES molecules are deposited on the substrate surface due to hydrolysis in a very short period of time. The used APTES molecular concentration and other parameters are related, but often the hydrolysis of a large number of APTES molecules can be completed within a few seconds, making the deposition reaction of APTES molecules on the substrate surface difficult to control

Therefore, it is difficult for people to obtain amino functional group modification with optimal immobilization effect on biomolecules, good reproducibility, and high throughput on the surface of polymer substrates through these two conventional modification methods.

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