A method for modifying the surface of a polymer with amino groups and a characterization method for its surface-related properties

Abstract

The invention relates to a method for modifying the surface of a polymer with amino groups and a method for characterizing its surface-related properties, comprising the following steps: firstly, the surface of the polymer substrate is subjected to hydroxylation treatment, and then immersed in an amino modification solution to carry out surface modification of the polymer substrate. Self-assembled, taken out, cleaned, dried, and then baked to complete curing. The amino modification solution is a compound solution of silane coupling agent and anhydrous polyol. The present invention can effectively adjust the diffusion kinetics of aminosilane molecules in the solvent after compounding the excellent viscosity performance of the polyol solvent in the modification liquid with the aminosilane coupling agent, and reduce the self-sufficiency of the aminosilane molecules on the surface of the polymer substrate. The assembly rate reaches the uniform thickness of the film formed by the self-assembly of aminosilane molecules on the surface of the polymer substrate, the amino functional active sites are sufficient, and the repeatability is high, which provides repeatability for subsequent polymer substrates in biosensors and biodetection analysis platforms Good performance, high-throughput immobilization platform provides the necessary premise.

Description

technical field [0001] The invention belongs to the field of nanometer materials, relates to a self-assembly method, in particular to a method for regulating and controlling the modification of amino groups on the surface of a polymer substrate. Background technique [0002] With the rapid development of today's high technology, people have been able to integrate various complex micro-nano structures on the surface of substrates of various materials, and then carry out specific functional modifications on the micro-nano structures on the substrate surface to realize the Features of functional applications. For example, in the field of microfluidic chip application technology that has developed rapidly in recent years, scientists first construct a micron-scale fluid channel structure on the surface of the substrate, that is, a microchannel. Through the design of the microchannel structure and the physical and chemical properties of the microchannel surface It realizes a high...

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Problems solved by technology

However, these two methods all have a common difficulty: the hydrolysis rate of APTES molecules on the substrate surface is very fast, and a large amount of APTES molecules are deposited on the substrate surface due to hydrolysis in a very short period of time. The used APTES molecular concentration and other parameters are related, but often the hydrolysis of a large number of APTES molecules can be completed within a few seconds, making the deposition reaction of APTES molecules on the substrate surface difficult to control

Therefore, it is difficult for people to obtain amino functional group modification with optimal immobilization effect on biomolecules, good reproducibility, and high throughput on the surface of polymer substrates through these two conventional modification methods.

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